Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810348903> ?p ?o ?g. }
- W2810348903 endingPage "6819" @default.
- W2810348903 startingPage "6812" @default.
- W2810348903 abstract "We report herein an investigation of carbazole-based cyanine, (E)-4-(2-(9-(2-(2-methoxyethoxy)ethyl)-9H-carbazol-3-yl)-vinyl)-1-methyl-quinolin-1-iumiodide (SLM), as an effective theranostic agent for Alzheimer's disease (AD). This cyanine exhibited desirable multifunctional and biological properties, including amyloid-β (Aβ)-oligomerization inhibition, blood-brain barrier permeability, low neurotoxicity, neuroprotective effect against Aβ-induced toxicities, high selectivity and strong binding interactions with Aβ peptide/species, good biostability, as well as strong fluorescence enhancement upon binding to Aβ species for diagnosis and therapy of AD. This cyanine has been successfully applied to perform near-infrared in vivo imaging of Aβ species in transgenic AD mouse model. The triple transgenic AD mice intraperitoneally treated with SLM showed significant recovery of cognitive deficits. Furthermore, those SLM-treated mice exhibited a substantial decrease in both of oligomeric Aβ contents and tau proteins in their brain, which was attributed to the induction of autophagic flux. These findings demonstrated for the first time that SLM is an effective theranostic agent with in vivo efficacy for diagnosis and treatment of AD in mouse models." @default.
- W2810348903 created "2018-07-10" @default.
- W2810348903 creator A5004616053 @default.
- W2810348903 creator A5007349948 @default.
- W2810348903 creator A5012301761 @default.
- W2810348903 creator A5019859894 @default.
- W2810348903 creator A5024781176 @default.
- W2810348903 creator A5038215479 @default.
- W2810348903 creator A5060741267 @default.
- W2810348903 creator A5063253432 @default.
- W2810348903 creator A5068249709 @default.
- W2810348903 creator A5088777548 @default.
- W2810348903 date "2018-06-25" @default.
- W2810348903 modified "2023-10-14" @default.
- W2810348903 title "Effective Theranostic Cyanine for Imaging of Amyloid Species in Vivo and Cognitive Improvements in Mouse Model" @default.
- W2810348903 cites W1523693806 @default.
- W2810348903 cites W1928822904 @default.
- W2810348903 cites W1965493795 @default.
- W2810348903 cites W1966361951 @default.
- W2810348903 cites W1977207025 @default.
- W2810348903 cites W1978116973 @default.
- W2810348903 cites W1987079564 @default.
- W2810348903 cites W2009468295 @default.
- W2810348903 cites W2013146608 @default.
- W2810348903 cites W2013448024 @default.
- W2810348903 cites W2016698723 @default.
- W2810348903 cites W2021439962 @default.
- W2810348903 cites W2030283639 @default.
- W2810348903 cites W2043291430 @default.
- W2810348903 cites W2044627978 @default.
- W2810348903 cites W2068249471 @default.
- W2810348903 cites W2075773387 @default.
- W2810348903 cites W2076199082 @default.
- W2810348903 cites W2094079632 @default.
- W2810348903 cites W2125461230 @default.
- W2810348903 cites W2128101513 @default.
- W2810348903 cites W2142120489 @default.
- W2810348903 cites W2143238979 @default.
- W2810348903 cites W2155260769 @default.
- W2810348903 cites W2166138110 @default.
- W2810348903 cites W2213821184 @default.
- W2810348903 cites W2221542309 @default.
- W2810348903 cites W2243723775 @default.
- W2810348903 cites W2264756347 @default.
- W2810348903 cites W2323149350 @default.
- W2810348903 cites W2327383607 @default.
- W2810348903 cites W2329658178 @default.
- W2810348903 cites W2713453502 @default.
- W2810348903 cites W2743254891 @default.
- W2810348903 doi "https://doi.org/10.1021/acsomega.8b00475" @default.
- W2810348903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6044748" @default.
- W2810348903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30023962" @default.
- W2810348903 hasPublicationYear "2018" @default.
- W2810348903 type Work @default.
- W2810348903 sameAs 2810348903 @default.
- W2810348903 citedByCount "27" @default.
- W2810348903 countsByYear W28103489032019 @default.
- W2810348903 countsByYear W28103489032020 @default.
- W2810348903 countsByYear W28103489032021 @default.
- W2810348903 countsByYear W28103489032022 @default.
- W2810348903 countsByYear W28103489032023 @default.
- W2810348903 crossrefType "journal-article" @default.
- W2810348903 hasAuthorship W2810348903A5004616053 @default.
- W2810348903 hasAuthorship W2810348903A5007349948 @default.
- W2810348903 hasAuthorship W2810348903A5012301761 @default.
- W2810348903 hasAuthorship W2810348903A5019859894 @default.
- W2810348903 hasAuthorship W2810348903A5024781176 @default.
- W2810348903 hasAuthorship W2810348903A5038215479 @default.
- W2810348903 hasAuthorship W2810348903A5060741267 @default.
- W2810348903 hasAuthorship W2810348903A5063253432 @default.
- W2810348903 hasAuthorship W2810348903A5068249709 @default.
- W2810348903 hasAuthorship W2810348903A5088777548 @default.
- W2810348903 hasBestOaLocation W28103489031 @default.
- W2810348903 hasConcept C102230213 @default.
- W2810348903 hasConcept C104317684 @default.
- W2810348903 hasConcept C121332964 @default.
- W2810348903 hasConcept C12554922 @default.
- W2810348903 hasConcept C141035611 @default.
- W2810348903 hasConcept C150903083 @default.
- W2810348903 hasConcept C178790620 @default.
- W2810348903 hasConcept C179104552 @default.
- W2810348903 hasConcept C185592680 @default.
- W2810348903 hasConcept C207001950 @default.
- W2810348903 hasConcept C25498285 @default.
- W2810348903 hasConcept C2777324032 @default.
- W2810348903 hasConcept C2777633098 @default.
- W2810348903 hasConcept C2779491297 @default.
- W2810348903 hasConcept C29730261 @default.
- W2810348903 hasConcept C55493867 @default.
- W2810348903 hasConcept C62520636 @default.
- W2810348903 hasConcept C71924100 @default.
- W2810348903 hasConcept C86803240 @default.
- W2810348903 hasConcept C91881484 @default.
- W2810348903 hasConcept C98274493 @default.
- W2810348903 hasConceptScore W2810348903C102230213 @default.
- W2810348903 hasConceptScore W2810348903C104317684 @default.
- W2810348903 hasConceptScore W2810348903C121332964 @default.
- W2810348903 hasConceptScore W2810348903C12554922 @default.