FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810366302> ?p ?o ?g. }

• W2810366302 endingPage "e0197842" @default.
• W2810366302 startingPage "e0197842" @default.
• W2810366302 abstract "Molecular imaging with a fluorescent version of Tilmanocept may permit an accurate and facile detection of sentinel nodes of endometrial cancer. Tilmanocept accumulates in sentinel lymph nodes (SLN) by binding to a cell surface receptor unique to macrophages and dendritic cells. Four female Yorkshire pigs underwent cervical stromal injection of IRDye800-Tilmanocept, a molecular imaging agent tagged with near-infrared fluorescent dye and radiolabeled with gallium-68 and technetium-99m. PET/CT scans 1.5 hours post-injection provided pre-operative SLN mapping. Robotic-assisted lymphadenectomy was performed two days after injection, using the FireFly imaging system to identify nodes demonstrating fluorescent signal. After removal of fluorescent nodes, pelvic and periaortic node dissections were performed. Nodes were assayed for technetium-99m activity, and SLNs were established using the “10%-rule”, requiring that the radioactivity of additional SLNs be greater than 10% of the “hottest” SLN. Thirty-four nodal samples were assayed ex vivo for radioactivity. All the SLNs satisfying the “10%-rule” were detected using the FireFly system. Five fluorescent nodes were detected, corresponding with preoperative PET/CT scan. Three pigs had one SLN and one pig had two SLNs, with 100% concordance between fluorescence and radioactivity. Fluorescent-labeled Tilmanocept permits real-time intraoperative detection of SLNs during robotic-assisted lymphadenectomy for endometrial cancer in a porcine model. When radiolabeled with gallium-68, Tilmanocept allows for preoperative localization of SLNs using PET/CT, and shows specificity to SLNs with persistent fluorescent signal, detectable using the FireFly system, for two days post-injection. In conclusion, these findings suggest that a phase I trial in human subjects is warranted, and that a long-term goal of an intra-operative administration of non-radioactive fluorescent-labeled Tilmanocept is possible." @default.
• W2810366302 created "2018-07-10" @default.
• W2810366302 creator A5010608848 @default.
• W2810366302 creator A5018972824 @default.
• W2810366302 creator A5039303466 @default.
• W2810366302 creator A5043166346 @default.
• W2810366302 creator A5045971507 @default.
• W2810366302 creator A5058012640 @default.
• W2810366302 creator A5058113326 @default.
• W2810366302 date "2018-07-02" @default.
• W2810366302 modified "2023-10-03" @default.
• W2810366302 title "Molecular Imaging of endometrial sentinel lymph nodes utilizing fluorescent-labeled Tilmanocept during robotic-assisted surgery in a porcine model" @default.
• W2810366302 cites W1069747139 @default.
• W2810366302 cites W1145411314 @default.
• W2810366302 cites W1899667088 @default.
• W2810366302 cites W1969901666 @default.
• W2810366302 cites W1983946784 @default.
• W2810366302 cites W2019233025 @default.
• W2810366302 cites W2024018449 @default.
• W2810366302 cites W2039394685 @default.
• W2810366302 cites W2040202232 @default.
• W2810366302 cites W2041367765 @default.
• W2810366302 cites W2047776320 @default.
• W2810366302 cites W2060562974 @default.
• W2810366302 cites W2069237192 @default.
• W2810366302 cites W2085628454 @default.
• W2810366302 cites W2108365078 @default.
• W2810366302 cites W2110615788 @default.
• W2810366302 cites W2113098018 @default.
• W2810366302 cites W2116264492 @default.
• W2810366302 cites W2152518875 @default.
• W2810366302 cites W2159307123 @default.
• W2810366302 cites W2166074462 @default.
• W2810366302 cites W2235523093 @default.
• W2810366302 cites W2284033377 @default.
• W2810366302 cites W2285490084 @default.
• W2810366302 cites W2324377928 @default.
• W2810366302 cites W2523379576 @default.
• W2810366302 cites W2547343898 @default.
• W2810366302 cites W2583455670 @default.
• W2810366302 cites W2584576044 @default.
• W2810366302 cites W2746832015 @default.
• W2810366302 cites W746189193 @default.
• W2810366302 doi "https://doi.org/10.1371/journal.pone.0197842" @default.
• W2810366302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6028102" @default.
• W2810366302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29965996" @default.
• W2810366302 hasPublicationYear "2018" @default.
• W2810366302 type Work @default.
• W2810366302 sameAs 2810366302 @default.
• W2810366302 citedByCount "12" @default.
• W2810366302 countsByYear W28103663022019 @default.
• W2810366302 countsByYear W28103663022020 @default.
• W2810366302 countsByYear W28103663022021 @default.
• W2810366302 countsByYear W28103663022022 @default.
• W2810366302 countsByYear W28103663022023 @default.
• W2810366302 crossrefType "journal-article" @default.
• W2810366302 hasAuthorship W2810366302A5010608848 @default.
• W2810366302 hasAuthorship W2810366302A5018972824 @default.
• W2810366302 hasAuthorship W2810366302A5039303466 @default.
• W2810366302 hasAuthorship W2810366302A5043166346 @default.
• W2810366302 hasAuthorship W2810366302A5045971507 @default.
• W2810366302 hasAuthorship W2810366302A5058012640 @default.
• W2810366302 hasAuthorship W2810366302A5058113326 @default.
• W2810366302 hasBestOaLocation W28103663021 @default.
• W2810366302 hasConcept C121332964 @default.
• W2810366302 hasConcept C121608353 @default.
• W2810366302 hasConcept C126322002 @default.
• W2810366302 hasConcept C136339569 @default.
• W2810366302 hasConcept C142724271 @default.
• W2810366302 hasConcept C150903083 @default.
• W2810366302 hasConcept C207001950 @default.
• W2810366302 hasConcept C26291073 @default.
• W2810366302 hasConcept C2777088508 @default.
• W2810366302 hasConcept C2779720271 @default.
• W2810366302 hasConcept C2780212769 @default.
• W2810366302 hasConcept C2780824555 @default.
• W2810366302 hasConcept C2780849966 @default.
• W2810366302 hasConcept C2989005 @default.
• W2810366302 hasConcept C530470458 @default.
• W2810366302 hasConcept C62520636 @default.
• W2810366302 hasConcept C71924100 @default.
• W2810366302 hasConcept C86803240 @default.
• W2810366302 hasConcept C91881484 @default.
• W2810366302 hasConceptScore W2810366302C121332964 @default.
• W2810366302 hasConceptScore W2810366302C121608353 @default.
• W2810366302 hasConceptScore W2810366302C126322002 @default.
• W2810366302 hasConceptScore W2810366302C136339569 @default.
• W2810366302 hasConceptScore W2810366302C142724271 @default.
• W2810366302 hasConceptScore W2810366302C150903083 @default.
• W2810366302 hasConceptScore W2810366302C207001950 @default.
• W2810366302 hasConceptScore W2810366302C26291073 @default.
• W2810366302 hasConceptScore W2810366302C2777088508 @default.
• W2810366302 hasConceptScore W2810366302C2779720271 @default.
• W2810366302 hasConceptScore W2810366302C2780212769 @default.
• W2810366302 hasConceptScore W2810366302C2780824555 @default.
• W2810366302 hasConceptScore W2810366302C2780849966 @default.
• W2810366302 hasConceptScore W2810366302C2989005 @default.
• W2810366302 hasConceptScore W2810366302C530470458 @default.

• next