Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810369401> ?p ?o ?g. }
- W2810369401 abstract "Abstract Alternative splicing (AS) is frequent during early mouse embryonic development. Specific histone post-translational modifications (hPTMs) have been shown to regulate exon splicing by either directly recruiting splice machinery or indirectly modulating transcriptional elongation. In this study, we hypothesized that hPTMs regulate expression of alternatively spliced genes for specific processes during differentiation. To address this notion, we applied an innovative machine learning approach to relate global hPTM enrichment to AS regulation during mammalian tissue development. We found that specific histone modifications, H3K36me3 and H3K4me1, play a dominant role in skipped exon selection among all the tissues and developmental time points examined. In addition, we used iterative random forest model to identify interactions of several hPTMs that associated with skipped exon selection during tissue development. Collectively, our data demonstrated a link between hPTMs and alternative splicing which will drive further experimental studies on the functional relevance of these modifications to alternative splicing." @default.
- W2810369401 created "2018-07-10" @default.
- W2810369401 creator A5010518637 @default.
- W2810369401 creator A5050692257 @default.
- W2810369401 creator A5066532319 @default.
- W2810369401 date "2018-07-04" @default.
- W2810369401 modified "2023-09-27" @default.
- W2810369401 title "Specific histone modifications associate with alternative exon selection during mammalian development" @default.
- W2810369401 cites W1506220252 @default.
- W2810369401 cites W1565545733 @default.
- W2810369401 cites W1964188377 @default.
- W2810369401 cites W1988460873 @default.
- W2810369401 cites W1992481904 @default.
- W2810369401 cites W1994288562 @default.
- W2810369401 cites W2001547716 @default.
- W2810369401 cites W2002669455 @default.
- W2810369401 cites W2007506415 @default.
- W2810369401 cites W2009329319 @default.
- W2810369401 cites W2011026836 @default.
- W2810369401 cites W2011920499 @default.
- W2810369401 cites W2019397670 @default.
- W2810369401 cites W2024036230 @default.
- W2810369401 cites W2056764302 @default.
- W2810369401 cites W2066231767 @default.
- W2810369401 cites W2066378949 @default.
- W2810369401 cites W2069725730 @default.
- W2810369401 cites W2072208761 @default.
- W2810369401 cites W2073654740 @default.
- W2810369401 cites W2075928340 @default.
- W2810369401 cites W2086474057 @default.
- W2810369401 cites W2090254120 @default.
- W2810369401 cites W2094887188 @default.
- W2810369401 cites W2096083625 @default.
- W2810369401 cites W2110776599 @default.
- W2810369401 cites W2123185146 @default.
- W2810369401 cites W2127081697 @default.
- W2810369401 cites W2138659224 @default.
- W2810369401 cites W2143658931 @default.
- W2810369401 cites W2144700381 @default.
- W2810369401 cites W2146091491 @default.
- W2810369401 cites W2150782426 @default.
- W2810369401 cites W2151202858 @default.
- W2810369401 cites W2151681456 @default.
- W2810369401 cites W2155804510 @default.
- W2810369401 cites W2164116506 @default.
- W2810369401 cites W2223556930 @default.
- W2810369401 cites W2259938310 @default.
- W2810369401 cites W2512648537 @default.
- W2810369401 cites W2612976808 @default.
- W2810369401 cites W2626688982 @default.
- W2810369401 cites W2949995114 @default.
- W2810369401 doi "https://doi.org/10.1101/361816" @default.
- W2810369401 hasPublicationYear "2018" @default.
- W2810369401 type Work @default.
- W2810369401 sameAs 2810369401 @default.
- W2810369401 citedByCount "2" @default.
- W2810369401 countsByYear W28103694012019 @default.
- W2810369401 crossrefType "posted-content" @default.
- W2810369401 hasAuthorship W2810369401A5010518637 @default.
- W2810369401 hasAuthorship W2810369401A5050692257 @default.
- W2810369401 hasAuthorship W2810369401A5066532319 @default.
- W2810369401 hasBestOaLocation W28103694011 @default.
- W2810369401 hasConcept C104317684 @default.
- W2810369401 hasConcept C119857082 @default.
- W2810369401 hasConcept C194583182 @default.
- W2810369401 hasConcept C2780989783 @default.
- W2810369401 hasConcept C36823959 @default.
- W2810369401 hasConcept C41008148 @default.
- W2810369401 hasConcept C54355233 @default.
- W2810369401 hasConcept C54458228 @default.
- W2810369401 hasConcept C64927066 @default.
- W2810369401 hasConcept C67705224 @default.
- W2810369401 hasConcept C70721500 @default.
- W2810369401 hasConcept C81917197 @default.
- W2810369401 hasConcept C86803240 @default.
- W2810369401 hasConcept C95444343 @default.
- W2810369401 hasConceptScore W2810369401C104317684 @default.
- W2810369401 hasConceptScore W2810369401C119857082 @default.
- W2810369401 hasConceptScore W2810369401C194583182 @default.
- W2810369401 hasConceptScore W2810369401C2780989783 @default.
- W2810369401 hasConceptScore W2810369401C36823959 @default.
- W2810369401 hasConceptScore W2810369401C41008148 @default.
- W2810369401 hasConceptScore W2810369401C54355233 @default.
- W2810369401 hasConceptScore W2810369401C54458228 @default.
- W2810369401 hasConceptScore W2810369401C64927066 @default.
- W2810369401 hasConceptScore W2810369401C67705224 @default.
- W2810369401 hasConceptScore W2810369401C70721500 @default.
- W2810369401 hasConceptScore W2810369401C81917197 @default.
- W2810369401 hasConceptScore W2810369401C86803240 @default.
- W2810369401 hasConceptScore W2810369401C95444343 @default.
- W2810369401 hasLocation W28103694011 @default.
- W2810369401 hasLocation W28103694012 @default.
- W2810369401 hasOpenAccess W2810369401 @default.
- W2810369401 hasPrimaryLocation W28103694011 @default.
- W2810369401 hasRelatedWork W2013123757 @default.
- W2810369401 hasRelatedWork W2085975240 @default.
- W2810369401 hasRelatedWork W2113067903 @default.
- W2810369401 hasRelatedWork W2115063609 @default.
- W2810369401 hasRelatedWork W2138045300 @default.
- W2810369401 hasRelatedWork W2385130702 @default.