Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810372421> ?p ?o ?g. }
- W2810372421 endingPage "29402" @default.
- W2810372421 startingPage "29392" @default.
- W2810372421 abstract "Cytomegalovirus (CMV)-based vaccine vectors are promising vaccine platforms because they induce strong and long-lasting immune responses. Recently it has been shown that vaccination with a mouse CMV (MCMV) vector expressing the melanoma-specific antigen TRP2 (MCMV-TRP2) protects mice against outgrowth of TRP2-positive B16 melanoma tumors, and this protection was dependent on the induction of IgG antibodies. Here we demonstrate that, although mice lacking all receptors for the Fc part of IgG (FcγRs) develop normal IgG responses after MCMV-TRP2 vaccination, the protection against B16 melanoma was completely abrogated, indicating that FcγRs are indispensable in the downstream effector pathway of the polyclonal anti-TRP2 antibody response. By investigating compound FcγR-deficient mouse strains and by using immune cell type-specific cell ablation we show that the IgG antibody-mediated tumor protection elicited by MCMV-TRP2 mainly depends on FcγRI expression on macrophages, whereas FcγRIV plays only a modest role. Thus, tumor-specific antibody therapy might benefit from combination therapy that recruits FcγRI-expressing pro-inflammatory macrophages to the tumor micro-environment." @default.
- W2810372421 created "2018-07-10" @default.
- W2810372421 creator A5001749725 @default.
- W2810372421 creator A5011904912 @default.
- W2810372421 creator A5014075850 @default.
- W2810372421 creator A5021665742 @default.
- W2810372421 creator A5025621864 @default.
- W2810372421 creator A5028047183 @default.
- W2810372421 creator A5035490415 @default.
- W2810372421 creator A5044218378 @default.
- W2810372421 creator A5068769338 @default.
- W2810372421 creator A5070695563 @default.
- W2810372421 creator A5078751582 @default.
- W2810372421 creator A5090318866 @default.
- W2810372421 date "2018-06-29" @default.
- W2810372421 modified "2023-10-12" @default.
- W2810372421 title "FcγRI expression on macrophages is required for antibody-mediated tumor protection by cytomegalovirus-based vaccines" @default.
- W2810372421 cites W1544333260 @default.
- W2810372421 cites W1601182655 @default.
- W2810372421 cites W1606109115 @default.
- W2810372421 cites W1969357190 @default.
- W2810372421 cites W1971097321 @default.
- W2810372421 cites W1977631644 @default.
- W2810372421 cites W1977967736 @default.
- W2810372421 cites W1984339045 @default.
- W2810372421 cites W2017098129 @default.
- W2810372421 cites W2018912432 @default.
- W2810372421 cites W2019602238 @default.
- W2810372421 cites W2028450449 @default.
- W2810372421 cites W2054532955 @default.
- W2810372421 cites W2057745345 @default.
- W2810372421 cites W2088715566 @default.
- W2810372421 cites W2099350409 @default.
- W2810372421 cites W2110990893 @default.
- W2810372421 cites W2117281169 @default.
- W2810372421 cites W2132661000 @default.
- W2810372421 cites W2134216732 @default.
- W2810372421 cites W2138118903 @default.
- W2810372421 cites W2167839299 @default.
- W2810372421 cites W2281676691 @default.
- W2810372421 cites W2295202170 @default.
- W2810372421 cites W2494370997 @default.
- W2810372421 cites W2550917340 @default.
- W2810372421 cites W2565114370 @default.
- W2810372421 cites W2597052847 @default.
- W2810372421 cites W2622901432 @default.
- W2810372421 cites W2749679400 @default.
- W2810372421 cites W2749771768 @default.
- W2810372421 cites W2791935577 @default.
- W2810372421 doi "https://doi.org/10.18632/oncotarget.25630" @default.
- W2810372421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6047664" @default.
- W2810372421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30034625" @default.
- W2810372421 hasPublicationYear "2018" @default.
- W2810372421 type Work @default.
- W2810372421 sameAs 2810372421 @default.
- W2810372421 citedByCount "10" @default.
- W2810372421 countsByYear W28103724212018 @default.
- W2810372421 countsByYear W28103724212019 @default.
- W2810372421 countsByYear W28103724212020 @default.
- W2810372421 countsByYear W28103724212021 @default.
- W2810372421 countsByYear W28103724212022 @default.
- W2810372421 crossrefType "journal-article" @default.
- W2810372421 hasAuthorship W2810372421A5001749725 @default.
- W2810372421 hasAuthorship W2810372421A5011904912 @default.
- W2810372421 hasAuthorship W2810372421A5014075850 @default.
- W2810372421 hasAuthorship W2810372421A5021665742 @default.
- W2810372421 hasAuthorship W2810372421A5025621864 @default.
- W2810372421 hasAuthorship W2810372421A5028047183 @default.
- W2810372421 hasAuthorship W2810372421A5035490415 @default.
- W2810372421 hasAuthorship W2810372421A5044218378 @default.
- W2810372421 hasAuthorship W2810372421A5068769338 @default.
- W2810372421 hasAuthorship W2810372421A5070695563 @default.
- W2810372421 hasAuthorship W2810372421A5078751582 @default.
- W2810372421 hasAuthorship W2810372421A5090318866 @default.
- W2810372421 hasBestOaLocation W28103724211 @default.
- W2810372421 hasConcept C159047783 @default.
- W2810372421 hasConcept C159654299 @default.
- W2810372421 hasConcept C203014093 @default.
- W2810372421 hasConcept C22070199 @default.
- W2810372421 hasConcept C2522874641 @default.
- W2810372421 hasConcept C2776409557 @default.
- W2810372421 hasConcept C2777658100 @default.
- W2810372421 hasConcept C2777701055 @default.
- W2810372421 hasConcept C2777732132 @default.
- W2810372421 hasConcept C2780727368 @default.
- W2810372421 hasConcept C502942594 @default.
- W2810372421 hasConcept C71924100 @default.
- W2810372421 hasConcept C86803240 @default.
- W2810372421 hasConcept C8891405 @default.
- W2810372421 hasConcept C956191 @default.
- W2810372421 hasConceptScore W2810372421C159047783 @default.
- W2810372421 hasConceptScore W2810372421C159654299 @default.
- W2810372421 hasConceptScore W2810372421C203014093 @default.
- W2810372421 hasConceptScore W2810372421C22070199 @default.
- W2810372421 hasConceptScore W2810372421C2522874641 @default.
- W2810372421 hasConceptScore W2810372421C2776409557 @default.
- W2810372421 hasConceptScore W2810372421C2777658100 @default.
- W2810372421 hasConceptScore W2810372421C2777701055 @default.