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• W2810395606 abstract "Scleroderma‐associated pulmonary arterial hypertension (SSc‐PAH) is associated with worse outcome than idiopathic pulmonary arterial hypertension (IPAH), potentially due to worse right ventricular adaptation to load as suggested by pressure–volume loop analysis. The value of non‐invasive load‐adaptability metrics has not been fully explored in SSc‐PAH. This study sought to assess whether patients with incident SSc‐PAH have worse echocardiographic load‐adaptability metrics than patients with IPAH. Twenty‐two patients with incident SSc‐PAH were matched 1:1 with IPAH based on pulmonary vascular resistance. Echocardiographic load‐adaptability indices were divided into: surrogates of ventriculo‐arterial coupling (e.g. right ventricular area change/end‐systolic area), indices reflecting the proportionality of load adaptation (e.g. tricuspid regurgitation velocity‐time integral normalized for average right ventricular radius), and simple ratios (e.g. tricuspid annular plane systolic excursion/right ventricular systolic pressure). The prognostic value of these indices for clinical worsening (i.e. death, transplant, or hospitalization for heart failure) at one year was explored. The two groups were comprised of patients of similar age, with similar cardiac index, pulmonary resistance, capacitance and NT‐proBNP levels ( p > 0.10). There was no difference in baseline right ventricular dimension, function or load‐adaptability indices. At one year, eight (36.4%) SSc‐PAH patients had experienced clinical worsening (eight hospitalizations and two deaths) versus one hospitalization in the IPAH group. Load adaptation at one year in survivors was not worse in SSc‐PAH ( p > 0.33). Patients with IPAH responded better to therapy than SSc‐PAH in terms of reduction of right ventricular areas at one year ( p < 0.05). Right ventricular load‐adaptability echocardiographic indices do not appear to capture the increased risk of negative outcomes at one year associated with SSc‐PAH." @default.
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• W2810395606 date "2018-07-01" @default.
• W2810395606 modified "2023-09-30" @default.
• W2810395606 title "Non‐invasive right ventricular load adaptability indices in patients with scleroderma‐associated pulmonary arterial hypertension" @default.
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• W2810395606 doi "https://doi.org/10.1177/2045894018788268" @default.
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