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• W2810476688 abstract "Abstract Background Macaques are outstanding animal models for the development of new contraceptives. In women, progestin‐only contraceptives often fail to block ovulation and are believed to act by altering cervix physiology. Herein, we assessed oviductal glycoprotein 1 (OVGP1) in the macaque cervix as a marker for progestogen action. Materials Rhesus macaques were treated with estradiol (E 2 ), E 2 plus progesterone (P), and E 2 plus levonorgestrel (LNG), a contraceptive progestin. Samples consisted of archived blocks of midcervix mucosa (epithelium and lamina propria) and fresh epithelial cells collected non‐invasively by cytobrush. OVGP 1 was assayed by quantitative real‐time PCR and localized by immunocytochemistry. Results OVGP 1 transcript was maximal after E 2 and reduced after treatment with E 2 + P ( P < .05). LNG also reduced OVGP 1 expression ( P < .05). OVGP 1‐specific staining localized to epithelial cells, and transcript was quantifiable in cytobrush collected samples. Conclusions OVGP 1 expression in cytobrush samples of macaque cervix provides a non‐invasive indicator of contraceptive progestin action." @default.
• W2810476688 created "2018-07-10" @default.
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• W2810476688 date "2018-07-04" @default.
• W2810476688 modified "2023-09-27" @default.
• W2810476688 title "Hormonal regulation of oviductal glycoprotein 1 (OVGP1; MUC9) in the rhesus macaque cervix" @default.
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• W2810476688 doi "https://doi.org/10.1111/jmp.12357" @default.
• W2810476688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6234059" @default.
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• W2810476688 hasPublicationYear "2018" @default.
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