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• W2810482015 abstract "Background Antimicrobial peptides ( AMP s) are an important component of cutaneous innate immunity. The amount of AMP s secreted in healthy and atopic patients is controversial. Hypotheses/Objectives To evaluate the antimicrobial effect of skin wash harvested from healthy and atopic dogs, the amount of AMP s ( cBD 3‐like/ cBD 122, cC ath, S100A8/9/12) present in the skin washes, and the correlation between AMP levels and severity of the clinical signs. Animals Fifteen healthy and 15 mildly atopic, privately owned dogs. Methods and materials Skin washes were performed on a 15 cm 2 area of nonlesional abdominal skin. The area was rinsed with 2.7 mL of saline using a sterile tube. Commercially available (S100A8/9/12) or in‐house ( cBD 3‐like and cC ath) canine‐specific ELISA s were performed. Skin washes were incubated with different concentrations (5 × 10 5 to 4 × 10 3 cfu/ mL ) of Staphylococcus pseudintermedius and the bacterial density measured after 24 h of incubation. Severity of clinical signs was assessed by the Canine Atopic Dermatitis Extent and Severity Index, 4 th version ( CADESI ‐04). Data were analysed statistically and significance level was set as P ≤ 0.05. Results There was no significant difference in any of the tested AMP s between healthy and atopic dogs. Strong/moderate positive correlations were seen between total and inguinal CADESI ‐04 ( r = 0.69; P = 0.0061) and between AMP s [ cBD 3‐like/ cC ath ( r = 0.69; P = 0.011), S100A8/S100A9 ( r = 0.8; P = 0.0016) and S100A9/S100A12 ( r = 0.57; P = 0.047)]. Significantly less antimicrobial activity was seen in skin washes from atopic versus healthy dogs ( P < 0.05). Conclusions and clinical importance This study found no difference in AMP secretion levels between healthy and nonlesional atopic canine skin. However, a significantly lower antimicrobial activity was present in the skin washes from atopic compared to healthy skin." @default.
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• W2810482015 date "2018-07-02" @default.
• W2810482015 modified "2023-10-16" @default.
• W2810482015 title "Evaluation of the secretion of antimicrobial peptides and antimicrobial effect of skin wash in atopic and healthy dogs: a preliminary study" @default.
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• W2810482015 doi "https://doi.org/10.1111/vde.12661" @default.
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