FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810578779> ?p ?o ?g. }

• W2810578779 endingPage "351" @default.
• W2810578779 startingPage "346" @default.
• W2810578779 abstract "Rich pharmacokinetic data on vancomycin in critically ill patients are lacking. The purpose of this study was to evaluate the pharmacokinetics of vancomycin in this population using rich pharmacokinetic sampling. Nineteen critically ill patients received individualized vancomycin doses by intermittent infusion to achieve target trough concentrations (15–20 mg/L). Blood samples were collected following the third or later dose of vancomycin. Serial blood samples were collected at 30 min following initiation of the vancomycin infusion; at the end of the infusion; serially at 60, 120, 300, and 480 min after the infusion finished; and immediately prior to the next dose. Vancomycin concentration–time profiles at steady state were fit to a noncompartmental model to determine the pharmacokinetic parameters. Vancomycin trough concentration was correlated to AUC0–24 (r = 0.83, P < 0.001). Total body weight was a predictor of volume of distribution (r = 0.43, P = 0.03). Age, serum creatinine, and creatinine clearance (CrCl) were found to be predictors for vancomycin clearance (r = −0.67, −0.52, and, 0.72, respectively). CrCl was the best predictor of vancomycin systemic clearance, and addition of other variables to a multivariate model failed to improve model fit. Vancomycin trough concentration may not be an adequate surrogate of AUC0–24. Additional research is needed to determine dosing strategies to optimize AUC0–24 while limiting toxicity." @default.
• W2810578779 created "2018-07-10" @default.
• W2810578779 creator A5016544640 @default.
• W2810578779 creator A5018624118 @default.
• W2810578779 creator A5024670758 @default.
• W2810578779 creator A5059890725 @default.
• W2810578779 creator A5060263920 @default.
• W2810578779 creator A5065382060 @default.
• W2810578779 date "2018-12-01" @default.
• W2810578779 modified "2023-09-27" @default.
• W2810578779 title "Prospective evaluation of vancomycin pharmacokinetics in a heterogeneous critically ill population" @default.
• W2810578779 cites W1841446236 @default.
• W2810578779 cites W1971251009 @default.
• W2810578779 cites W1972470346 @default.
• W2810578779 cites W1973795734 @default.
• W2810578779 cites W1993016987 @default.
• W2810578779 cites W2010066166 @default.
• W2810578779 cites W2015509605 @default.
• W2810578779 cites W2030833828 @default.
• W2810578779 cites W2057605178 @default.
• W2810578779 cites W2059568900 @default.
• W2810578779 cites W2094272037 @default.
• W2810578779 cites W2099365065 @default.
• W2810578779 cites W2108433768 @default.
• W2810578779 cites W2109144391 @default.
• W2810578779 cites W2116736766 @default.
• W2810578779 cites W2127473408 @default.
• W2810578779 cites W2132889658 @default.
• W2810578779 cites W2133120422 @default.
• W2810578779 cites W2133613588 @default.
• W2810578779 cites W2137476069 @default.
• W2810578779 cites W2139890423 @default.
• W2810578779 cites W2144504167 @default.
• W2810578779 cites W2152771638 @default.
• W2810578779 cites W2153641174 @default.
• W2810578779 cites W2211011580 @default.
• W2810578779 cites W2162160795 @default.
• W2810578779 doi "https://doi.org/10.1016/j.diagmicrobio.2018.06.022" @default.
• W2810578779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30025969" @default.
• W2810578779 hasPublicationYear "2018" @default.
• W2810578779 type Work @default.
• W2810578779 sameAs 2810578779 @default.
• W2810578779 citedByCount "21" @default.
• W2810578779 countsByYear W28105787792018 @default.
• W2810578779 countsByYear W28105787792019 @default.
• W2810578779 countsByYear W28105787792020 @default.
• W2810578779 countsByYear W28105787792021 @default.
• W2810578779 countsByYear W28105787792022 @default.
• W2810578779 countsByYear W28105787792023 @default.
• W2810578779 crossrefType "journal-article" @default.
• W2810578779 hasAuthorship W2810578779A5016544640 @default.
• W2810578779 hasAuthorship W2810578779A5018624118 @default.
• W2810578779 hasAuthorship W2810578779A5024670758 @default.
• W2810578779 hasAuthorship W2810578779A5059890725 @default.
• W2810578779 hasAuthorship W2810578779A5060263920 @default.
• W2810578779 hasAuthorship W2810578779A5065382060 @default.
• W2810578779 hasConcept C112705442 @default.
• W2810578779 hasConcept C126322002 @default.
• W2810578779 hasConcept C139254425 @default.
• W2810578779 hasConcept C159641895 @default.
• W2810578779 hasConcept C185592680 @default.
• W2810578779 hasConcept C2777288759 @default.
• W2810578779 hasConcept C2778980435 @default.
• W2810578779 hasConcept C2779489039 @default.
• W2810578779 hasConcept C2780272996 @default.
• W2810578779 hasConcept C2780306776 @default.
• W2810578779 hasConcept C2908647359 @default.
• W2810578779 hasConcept C2910800852 @default.
• W2810578779 hasConcept C3019249092 @default.
• W2810578779 hasConcept C501593827 @default.
• W2810578779 hasConcept C523546767 @default.
• W2810578779 hasConcept C54355233 @default.
• W2810578779 hasConcept C55493867 @default.
• W2810578779 hasConcept C71924100 @default.
• W2810578779 hasConcept C86803240 @default.
• W2810578779 hasConcept C98274493 @default.
• W2810578779 hasConcept C99454951 @default.
• W2810578779 hasConceptScore W2810578779C112705442 @default.
• W2810578779 hasConceptScore W2810578779C126322002 @default.
• W2810578779 hasConceptScore W2810578779C139254425 @default.
• W2810578779 hasConceptScore W2810578779C159641895 @default.
• W2810578779 hasConceptScore W2810578779C185592680 @default.
• W2810578779 hasConceptScore W2810578779C2777288759 @default.
• W2810578779 hasConceptScore W2810578779C2778980435 @default.
• W2810578779 hasConceptScore W2810578779C2779489039 @default.
• W2810578779 hasConceptScore W2810578779C2780272996 @default.
• W2810578779 hasConceptScore W2810578779C2780306776 @default.
• W2810578779 hasConceptScore W2810578779C2908647359 @default.
• W2810578779 hasConceptScore W2810578779C2910800852 @default.
• W2810578779 hasConceptScore W2810578779C3019249092 @default.
• W2810578779 hasConceptScore W2810578779C501593827 @default.
• W2810578779 hasConceptScore W2810578779C523546767 @default.
• W2810578779 hasConceptScore W2810578779C54355233 @default.
• W2810578779 hasConceptScore W2810578779C55493867 @default.
• W2810578779 hasConceptScore W2810578779C71924100 @default.
• W2810578779 hasConceptScore W2810578779C86803240 @default.
• W2810578779 hasConceptScore W2810578779C98274493 @default.
• W2810578779 hasConceptScore W2810578779C99454951 @default.

• next