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- W2810601223 abstract "ABSTRACT Cell elongation in rod-shaped bacteria is mediated by the Rod system, a conserved morphogenic complex that spatially controls cell wall (CW) assembly. In Escherichia coli , alterations in a CW synthase component of the system called PBP2 were identified that overcome other inactivating defects. Rod system activity was stimulated in the suppressors in vivo, and purified synthase complexes with these changes showed more robust CW synthesis in vitro. Polymerization of the actin-like MreB component of the Rod system was also found to be enhanced in cells with the activated synthase. The results suggest an activation pathway governing Rod system function in which PBP2 conformation plays a central role in stimulating both CW glycan polymerization by its partner RodA and the formation of cytoskeletal filaments of MreB to orient CW assembly. An analogous activation pathway involving similar enzymatic components is likely responsible for controlling CW synthesis by the division machinery." @default.
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- W2810601223 date "2018-06-29" @default.
- W2810601223 modified "2023-10-11" @default.
- W2810601223 title "An activation pathway governs cell wall polymerization by a bacterial morphogenic machine" @default.
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- W2810601223 doi "https://doi.org/10.1101/359208" @default.
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