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• W2810618080 abstract "The innate immune response is the rapid response system to microbial invasion. Innate immunity evolved to recognize and immediately initiate host defenses to limit damage and activate antimicrobial clearance mechanisms. The human innate immune system is highly integrated with, and coregulated by, two other critical host defense systems, the coagulation system and the adaptive immune systems. Many of the same sensing mechanisms and inflammatory signaling mechanisms in response to pathogen invasion also come into play after tissue injury and cellular necrosis. A system of receptors found primarily on myeloid cells of the innate immune system recognizes microbial threats by detecting evolutionarily conserved molecular patterns found exclusively in microbial pathogens called pathogen-associated molecular patterns (PAMPs). Similarly, injury to human cells from any cause is rapidly detectable via recognition receptors found on innate immune cells called damage-associated molecular patterns (DAMPs). Detection of either PAMPs or DAMPs signals immediate danger to the host. Innate immune responses are designed to wall off the site of injury by release of procoagulant factors for clot formation proinflammatory signals to bring phagocytes into the tissue to clear microbial invaders and begin tissue repair. The nature of these responses and the cellular mechanisms that underlie innate immunity are reviewed in this chapter." @default.
• W2810618080 created "2018-07-10" @default.
• W2810618080 creator A5025379878 @default.
• W2810618080 date "2019-01-01" @default.
• W2810618080 modified "2023-10-17" @default.
• W2810618080 title "Innate Immunity and the Kidney" @default.
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• W2810618080 doi "https://doi.org/10.1016/b978-0-323-44942-7.00082-0" @default.
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