Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810629007> ?p ?o ?g. }
- W2810629007 endingPage "365" @default.
- W2810629007 startingPage "354" @default.
- W2810629007 abstract "Autophagy is a process the primary role of which is to clear up damaged cellular components such as long-lived proteins and organelles, thus participating in the conservation of different cells. Osteoporosis associated with aging is characterized by consistent changes in bone metabolism with suppression of bone formation as well as increased bone resorption. In advanced age, not only bone mass but also bone strength decrease in both sexes, resulting in an increased incidence of fractures. Clinical and animal experiments reveal that age-related bone loss is associated with many factors such as accumulation of autophagy, increased levels of reactive oxygen species, sex hormone deficiency, and high levels of endogenous glucocorticoids. Available basic and clinical studies indicate that age-associated factors can regulate autophagy. Those factors play important roles in bone remodeling and contribute to decreased bone mass and bone strength with aging. In this review, we summarize the mechanisms involved in bone metabolism related to aging and autophagy, supplying a theory for therapeutic targets to rescue bone mass and bone strength in older people." @default.
- W2810629007 created "2018-07-10" @default.
- W2810629007 creator A5000443073 @default.
- W2810629007 creator A5028581203 @default.
- W2810629007 creator A5029989843 @default.
- W2810629007 creator A5041234550 @default.
- W2810629007 creator A5050947917 @default.
- W2810629007 creator A5052234397 @default.
- W2810629007 creator A5054559446 @default.
- W2810629007 creator A5056480265 @default.
- W2810629007 creator A5060766870 @default.
- W2810629007 date "2019-01-25" @default.
- W2810629007 modified "2023-10-01" @default.
- W2810629007 title "Autophagy: A Promising Target for Age-related Osteoporosis" @default.
- W2810629007 cites W1494339596 @default.
- W2810629007 cites W1507243371 @default.
- W2810629007 cites W1544206285 @default.
- W2810629007 cites W1551825908 @default.
- W2810629007 cites W1561293749 @default.
- W2810629007 cites W1575065086 @default.
- W2810629007 cites W162622494 @default.
- W2810629007 cites W1644079882 @default.
- W2810629007 cites W1676796596 @default.
- W2810629007 cites W1950742672 @default.
- W2810629007 cites W1967874462 @default.
- W2810629007 cites W1969807770 @default.
- W2810629007 cites W1970270883 @default.
- W2810629007 cites W1972542282 @default.
- W2810629007 cites W1974220279 @default.
- W2810629007 cites W1974560134 @default.
- W2810629007 cites W1976091683 @default.
- W2810629007 cites W1976402969 @default.
- W2810629007 cites W1980981669 @default.
- W2810629007 cites W1985478291 @default.
- W2810629007 cites W1986714785 @default.
- W2810629007 cites W1987108430 @default.
- W2810629007 cites W1988170766 @default.
- W2810629007 cites W1989764974 @default.
- W2810629007 cites W1992637537 @default.
- W2810629007 cites W1994443543 @default.
- W2810629007 cites W1996028579 @default.
- W2810629007 cites W1996735611 @default.
- W2810629007 cites W1997323954 @default.
- W2810629007 cites W2001675597 @default.
- W2810629007 cites W2002306991 @default.
- W2810629007 cites W2002521640 @default.
- W2810629007 cites W2002831974 @default.
- W2810629007 cites W2003733256 @default.
- W2810629007 cites W2004485238 @default.
- W2810629007 cites W2006328604 @default.
- W2810629007 cites W2006840724 @default.
- W2810629007 cites W2008973916 @default.
- W2810629007 cites W2014140858 @default.
- W2810629007 cites W2015005969 @default.
- W2810629007 cites W2016674232 @default.
- W2810629007 cites W2018652887 @default.
- W2810629007 cites W2019713643 @default.
- W2810629007 cites W2020229324 @default.
- W2810629007 cites W2021693450 @default.
- W2810629007 cites W2021829493 @default.
- W2810629007 cites W2023127783 @default.
- W2810629007 cites W2023994136 @default.
- W2810629007 cites W2024039167 @default.
- W2810629007 cites W2024782183 @default.
- W2810629007 cites W2025364264 @default.
- W2810629007 cites W2025389245 @default.
- W2810629007 cites W2025665129 @default.
- W2810629007 cites W2026467905 @default.
- W2810629007 cites W2027469592 @default.
- W2810629007 cites W2028536701 @default.
- W2810629007 cites W2028608421 @default.
- W2810629007 cites W2028934766 @default.
- W2810629007 cites W2033606928 @default.
- W2810629007 cites W2035385237 @default.
- W2810629007 cites W2037507546 @default.
- W2810629007 cites W2040533720 @default.
- W2810629007 cites W2041869246 @default.
- W2810629007 cites W2042741613 @default.
- W2810629007 cites W2042861901 @default.
- W2810629007 cites W2044135603 @default.
- W2810629007 cites W2045801131 @default.
- W2810629007 cites W2046279838 @default.
- W2810629007 cites W2049089797 @default.
- W2810629007 cites W2052533937 @default.
- W2810629007 cites W2053648508 @default.
- W2810629007 cites W2058484936 @default.
- W2810629007 cites W2062795063 @default.
- W2810629007 cites W2064093478 @default.
- W2810629007 cites W2064543792 @default.
- W2810629007 cites W2065463296 @default.
- W2810629007 cites W2065651226 @default.
- W2810629007 cites W2066314626 @default.
- W2810629007 cites W2067208577 @default.
- W2810629007 cites W2072050034 @default.
- W2810629007 cites W2073406262 @default.
- W2810629007 cites W2077908546 @default.
- W2810629007 cites W2078536317 @default.
- W2810629007 cites W2079934976 @default.