Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810654871> ?p ?o ?g. }
- W2810654871 endingPage "1628" @default.
- W2810654871 startingPage "1617" @default.
- W2810654871 abstract "Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting motor neurons and other neuronal cells, leading to severe disability and eventually death from ventilatory failure. It has a prevalence of 5 in 100,000, with an incidence of 1.7 per 100,000, reflecting short average survival. The pathogenesis is incompletely understood, but defects of RNA processing and protein clearance may be fundamental. Repeat expansions in the chromosome 9 open reading frame 72 gene (C9orf72) are the most common known genetic cause of ALS and are seen in approximately 40% of patients with a family history and approximately 10% of those without. No environmental risk factors are proved to be causative, but many have been proposed, including military service. The diagnosis of ALS rests on a history of painless progressive weakness coupled with examination findings of upper and lower motor dysfunction. No diagnostic test is yet available, but electromyography and genetic tests can support the diagnosis. Care for patients is best provided by a multidisciplinary team, and most interventions are directed at managing symptoms. Two medications with modest benefits have Food and Drug Administration approval for the treatment of ALS: riluzole, a glutamate receptor antagonist, and, new in 2017, edaravone, a free radical scavenger. Many other encouraging treatment strategies are being explored in clinical trials for ALS; herein we review stem cell and antisense oligonucleotide gene therapies." @default.
- W2810654871 created "2018-07-10" @default.
- W2810654871 creator A5052581382 @default.
- W2810654871 creator A5084777911 @default.
- W2810654871 creator A5086394733 @default.
- W2810654871 date "2018-11-01" @default.
- W2810654871 modified "2023-10-18" @default.
- W2810654871 title "Amyotrophic Lateral Sclerosis: An Update for 2018" @default.
- W2810654871 cites W1510400828 @default.
- W2810654871 cites W1619082318 @default.
- W2810654871 cites W1937475214 @default.
- W2810654871 cites W1973382140 @default.
- W2810654871 cites W1977399503 @default.
- W2810654871 cites W1979313188 @default.
- W2810654871 cites W1983633543 @default.
- W2810654871 cites W1983734876 @default.
- W2810654871 cites W1984078408 @default.
- W2810654871 cites W1984308849 @default.
- W2810654871 cites W1991208268 @default.
- W2810654871 cites W1993184479 @default.
- W2810654871 cites W2003618511 @default.
- W2810654871 cites W2003847460 @default.
- W2810654871 cites W2007068311 @default.
- W2810654871 cites W2011007124 @default.
- W2810654871 cites W2016879629 @default.
- W2810654871 cites W2031964319 @default.
- W2810654871 cites W2034183549 @default.
- W2810654871 cites W2038070128 @default.
- W2810654871 cites W2045749667 @default.
- W2810654871 cites W2048813950 @default.
- W2810654871 cites W2050626075 @default.
- W2810654871 cites W2061194981 @default.
- W2810654871 cites W2067161638 @default.
- W2810654871 cites W2068843824 @default.
- W2810654871 cites W2072981065 @default.
- W2810654871 cites W2073073462 @default.
- W2810654871 cites W2076491580 @default.
- W2810654871 cites W2085165928 @default.
- W2810654871 cites W2088483634 @default.
- W2810654871 cites W2097843267 @default.
- W2810654871 cites W2105483880 @default.
- W2810654871 cites W2107401597 @default.
- W2810654871 cites W2109712577 @default.
- W2810654871 cites W2127861463 @default.
- W2810654871 cites W2128167427 @default.
- W2810654871 cites W2128768698 @default.
- W2810654871 cites W2132516584 @default.
- W2810654871 cites W2134585986 @default.
- W2810654871 cites W2134833646 @default.
- W2810654871 cites W2136448211 @default.
- W2810654871 cites W2140150532 @default.
- W2810654871 cites W2140248514 @default.
- W2810654871 cites W2143035838 @default.
- W2810654871 cites W2145330051 @default.
- W2810654871 cites W2145697686 @default.
- W2810654871 cites W2147729862 @default.
- W2810654871 cites W2150523249 @default.
- W2810654871 cites W2153410398 @default.
- W2810654871 cites W2154945114 @default.
- W2810654871 cites W2155683527 @default.
- W2810654871 cites W2156054547 @default.
- W2810654871 cites W2156454183 @default.
- W2810654871 cites W2156969855 @default.
- W2810654871 cites W2157150055 @default.
- W2810654871 cites W2157811993 @default.
- W2810654871 cites W2159556459 @default.
- W2810654871 cites W2162668123 @default.
- W2810654871 cites W2165915651 @default.
- W2810654871 cites W2167568122 @default.
- W2810654871 cites W2177636519 @default.
- W2810654871 cites W2181079527 @default.
- W2810654871 cites W2193543187 @default.
- W2810654871 cites W2229303261 @default.
- W2810654871 cites W2234902113 @default.
- W2810654871 cites W2268354613 @default.
- W2810654871 cites W2304886140 @default.
- W2810654871 cites W2314689571 @default.
- W2810654871 cites W2321639288 @default.
- W2810654871 cites W2336547243 @default.
- W2810654871 cites W2338545563 @default.
- W2810654871 cites W2380836599 @default.
- W2810654871 cites W2396610607 @default.
- W2810654871 cites W2462775742 @default.
- W2810654871 cites W2514038941 @default.
- W2810654871 cites W2527286710 @default.
- W2810654871 cites W2531560122 @default.
- W2810654871 cites W2533664860 @default.
- W2810654871 cites W2535742549 @default.
- W2810654871 cites W2539567223 @default.
- W2810654871 cites W2553826027 @default.
- W2810654871 cites W2580246530 @default.
- W2810654871 cites W2597399186 @default.
- W2810654871 cites W2599471352 @default.
- W2810654871 cites W2616124858 @default.
- W2810654871 cites W2620578423 @default.
- W2810654871 cites W2621074820 @default.
- W2810654871 cites W2676001006 @default.
- W2810654871 cites W2735021289 @default.