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• W2810689754 endingPage "248" @default.
• W2810689754 startingPage "248" @default.
• W2810689754 abstract "DNA damage induced by ionizing radiation exposure is enhanced in the presence of oxygen (the “oxygen effect”). Despite its practical importance in radiotherapy, the oxygen effect has largely been excluded from models that predict DNA damage from radiation tracks. A Monte Carlo-based algorithm was developed in MATLAB software to predict DNA damage from physical and chemical tracks through a cell nucleus simulated in Geant4-DNA, taking into account the effects of cellular oxygenation (pO2) on DNA radical chemistry processes. An initial spatial distribution of DNA base and sugar radicals was determined by spatially clustering direct events (that deposited at least 10.79 eV) and hydroxyl radical (•OH) interactions. The oxygen effect was modeled by increasing the efficiency with which sugar radicals from direct-type effects were converted to strand breaks from 0.6 to 1, the efficiency with which sugar radicals from the indirect effect were converted to strand breaks from 0.28 to 1 and the efficiency of base-to-sugar radical transfer from •OH-mediated base radicals from 0 to 0.03 with increasing pO2 from 0 to 760 mmHg. The DNA damage induction algorithm was applied to tracks from electrons, protons and alphas with LET values from 0.2 to 150 keV/μm under different pO2 conditions. The oxygen enhancement ratio for double-strand break induction was 3.0 for low-LET radiation up to approximately 15 keV/μm, after which it gradually decreased to a value of 1.3 at 150 keV/μm. These values were consistent with a range of experimental data published in the literature. The DNA damage yields were verified using experimental data in the literature and results from other theoretical models. The spatial clustering approach developed in this work has low memory requirements and may be suitable for particle tracking simulations with a large number of cells." @default.
• W2810689754 created "2018-07-10" @default.
• W2810689754 creator A5027460327 @default.
• W2810689754 creator A5027842654 @default.
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• W2810689754 creator A5072344157 @default.
• W2810689754 date "2018-06-28" @default.
• W2810689754 modified "2023-10-17" @default.
• W2810689754 title "Monte Carlo Simulation of the Oxygen Effect in DNA Damage Induction by Ionizing Radiation" @default.
• W2810689754 cites W1603398525 @default.
• W2810689754 cites W1957823868 @default.
• W2810689754 cites W1966655688 @default.
• W2810689754 cites W1972265397 @default.
• W2810689754 cites W1973702758 @default.
• W2810689754 cites W1977443433 @default.
• W2810689754 cites W1978654165 @default.
• W2810689754 cites W1983598709 @default.
• W2810689754 cites W1987824639 @default.
• W2810689754 cites W1991688352 @default.
• W2810689754 cites W1992161582 @default.
• W2810689754 cites W1992628502 @default.
• W2810689754 cites W1992931208 @default.
• W2810689754 cites W1995807169 @default.
• W2810689754 cites W1997801804 @default.
• W2810689754 cites W1998169010 @default.
• W2810689754 cites W1999666772 @default.
• W2810689754 cites W2001084660 @default.
• W2810689754 cites W2004161017 @default.
• W2810689754 cites W2005406598 @default.
• W2810689754 cites W2011410955 @default.
• W2810689754 cites W2015460353 @default.
• W2810689754 cites W2026812997 @default.
• W2810689754 cites W2027784487 @default.
• W2810689754 cites W2029860375 @default.
• W2810689754 cites W2037426867 @default.
• W2810689754 cites W2037897848 @default.
• W2810689754 cites W2038450079 @default.
• W2810689754 cites W2040121959 @default.
• W2810689754 cites W2042726154 @default.
• W2810689754 cites W2047259183 @default.
• W2810689754 cites W2049006737 @default.
• W2810689754 cites W2057047042 @default.
• W2810689754 cites W2058323309 @default.
• W2810689754 cites W2058636364 @default.
• W2810689754 cites W2065911620 @default.
• W2810689754 cites W2066894074 @default.
• W2810689754 cites W2070004347 @default.
• W2810689754 cites W2070082649 @default.
• W2810689754 cites W2074687585 @default.
• W2810689754 cites W2075051321 @default.
• W2810689754 cites W2077055697 @default.
• W2810689754 cites W2086629485 @default.
• W2810689754 cites W2089253822 @default.
• W2810689754 cites W2089608829 @default.
• W2810689754 cites W2090220808 @default.
• W2810689754 cites W2096736575 @default.
• W2810689754 cites W2100125421 @default.
• W2810689754 cites W2108213918 @default.
• W2810689754 cites W2125667702 @default.
• W2810689754 cites W2127327054 @default.
• W2810689754 cites W2129637612 @default.
• W2810689754 cites W2131379143 @default.
• W2810689754 cites W2134126465 @default.
• W2810689754 cites W2134604869 @default.
• W2810689754 cites W2135435328 @default.
• W2810689754 cites W2143470969 @default.
• W2810689754 cites W2151272689 @default.
• W2810689754 cites W2154184572 @default.
• W2810689754 cites W2164043833 @default.
• W2810689754 cites W2166008919 @default.
• W2810689754 cites W2188489292 @default.
• W2810689754 cites W2189227215 @default.
• W2810689754 cites W2197178232 @default.
• W2810689754 cites W2216662254 @default.
• W2810689754 cites W2225096088 @default.
• W2810689754 cites W2270181264 @default.
• W2810689754 cites W2291766833 @default.
• W2810689754 cites W2312209333 @default.
• W2810689754 cites W2326686334 @default.
• W2810689754 cites W2411543955 @default.
• W2810689754 cites W2505074369 @default.
• W2810689754 cites W2568928300 @default.
• W2810689754 cites W2598773989 @default.
• W2810689754 cites W2745542976 @default.
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• W2810689754 cites W4239833133 @default.
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• W2810689754 doi "https://doi.org/10.1667/rr15050.1" @default.
• W2810689754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29953346" @default.
• W2810689754 hasPublicationYear "2018" @default.
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