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- W2810701799 abstract "Significance In addition to functioning as a delayed-rectifier K + channel, Kv2.1 interacts with the cortical endoplasmic reticulum (ER) in hippocampal neurons to form somatic ER/plasma membrane (ER/PM) junctions. Neuronal activity and insult induce Kv2.1 release from the cortical ER and subsequent ER withdrawal from the PM. Neuronal ER/PM contacts represent >10% of the cell surface and play roles in membrane trafficking, the regulation of burst firing, Ca 2+ homeostasis, and control of PM lipid. We report here that Kv2 channel–VAMP-associated protein (VAP) interaction tethers the cortical ER to the PM via a noncanonical FFAT motif contained within the channel C terminus. Since VAPs have a wide-ranging interactome, Kv2-induced ER remodeling and VAP concentration at ER/PM contacts likely play a central role in neuronal physiology." @default.
- W2810701799 created "2018-07-10" @default.
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- W2810701799 date "2018-06-25" @default.
- W2810701799 modified "2023-10-16" @default.
- W2810701799 title "Kv2 potassium channels form endoplasmic reticulum/plasma membrane junctions via interaction with VAPA and VAPB" @default.
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- W2810701799 doi "https://doi.org/10.1073/pnas.1805757115" @default.
- W2810701799 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6077746" @default.
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