Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810706768> ?p ?o ?g. }
- W2810706768 abstract "Prenatal alcohol exposure (PAE) is known to elicit a broad range of systemic effects, including neurophysiological alterations that result in adverse behavioural and cognitive outcomes. However, molecular pathways underlying these long-term intrauterine effects remain to be investigated. Here we tested a hypothesis that PAE may lead to epigenetic alterations to the DNA resulting in attentional and cognitive alterations of the children. We report the results of the study that included 156 primary school children of the Franconian Cognition and Emotion Studies (FRANCES) cohort which were tested for an objective marker of PAE, ethyl glucuronide (EtG) in meconium at birth. 32 newborns were found to be exposed to alcohol with EtG values above 30 ng/g (EtG+). Previously we described PAE being associated with lower IQ and smaller amplitude of the event-related potential component P3 in go trials (Go-P3), which indicates a reduced capacity of attentional resources. Whole genome methylation analysis of the buccal cell DNA revealed 193 differentially methylated genes in children with positive meconium EtG, that were clustered into groups involved in epigenetic modifications, neurodegeneration, neurodevelopment, axon guidance and neuronal excitability. Furthermore, we detect mediation effects of the methylation changes in DPP10 and SLC16A9 genes on the EtG related cognitive and attention-related deficits. Our results suggest that system-wide epigenetic changes are involved in life-long effects of prenatal alcohol exposure. In particular, we show an epigenetic mediation of PAE effects on cognition and attention-related processes." @default.
- W2810706768 created "2018-07-10" @default.
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- W2810706768 date "2018-06-26" @default.
- W2810706768 modified "2023-10-01" @default.
- W2810706768 title "Prenatal Alcohol Exposure Is Associated With Adverse Cognitive Effects and Distinct Whole-Genome DNA Methylation Patterns in Primary School Children" @default.
- W2810706768 cites W118021982 @default.
- W2810706768 cites W1641004652 @default.
- W2810706768 cites W1964065942 @default.
- W2810706768 cites W1964401196 @default.
- W2810706768 cites W1965388596 @default.
- W2810706768 cites W1966634013 @default.
- W2810706768 cites W1966943396 @default.
- W2810706768 cites W1969560858 @default.
- W2810706768 cites W1971870075 @default.
- W2810706768 cites W1972929565 @default.
- W2810706768 cites W1974047233 @default.
- W2810706768 cites W1976557740 @default.
- W2810706768 cites W1979506865 @default.
- W2810706768 cites W1985213868 @default.
- W2810706768 cites W1986849101 @default.
- W2810706768 cites W1992908805 @default.
- W2810706768 cites W2003454149 @default.
- W2810706768 cites W2003503128 @default.
- W2810706768 cites W2003535797 @default.
- W2810706768 cites W2003844569 @default.
- W2810706768 cites W2010984732 @default.
- W2810706768 cites W2011290738 @default.
- W2810706768 cites W2012548084 @default.
- W2810706768 cites W2014797104 @default.
- W2810706768 cites W2015310317 @default.
- W2810706768 cites W2020001055 @default.
- W2810706768 cites W2027787681 @default.
- W2810706768 cites W2029726120 @default.
- W2810706768 cites W2030185131 @default.
- W2810706768 cites W2030558299 @default.
- W2810706768 cites W2033057884 @default.
- W2810706768 cites W2035473823 @default.
- W2810706768 cites W2043594051 @default.
- W2810706768 cites W2048368626 @default.
- W2810706768 cites W2051268137 @default.
- W2810706768 cites W2053685483 @default.
- W2810706768 cites W2061161238 @default.
- W2810706768 cites W2061230077 @default.
- W2810706768 cites W2062403124 @default.
- W2810706768 cites W2065498897 @default.
- W2810706768 cites W2074670747 @default.
- W2810706768 cites W2075213530 @default.
- W2810706768 cites W2076962124 @default.
- W2810706768 cites W2079544007 @default.
- W2810706768 cites W2085059034 @default.
- W2810706768 cites W2085167130 @default.
- W2810706768 cites W2092145430 @default.
- W2810706768 cites W2094116748 @default.
- W2810706768 cites W2098140414 @default.
- W2810706768 cites W2101870168 @default.
- W2810706768 cites W2105912300 @default.
- W2810706768 cites W2111629986 @default.
- W2810706768 cites W2112296601 @default.
- W2810706768 cites W2113336683 @default.
- W2810706768 cites W2114512489 @default.
- W2810706768 cites W2119883345 @default.
- W2810706768 cites W2119907069 @default.
- W2810706768 cites W2123858748 @default.
- W2810706768 cites W2133465414 @default.
- W2810706768 cites W2139075355 @default.
- W2810706768 cites W2139109109 @default.
- W2810706768 cites W2140978738 @default.
- W2810706768 cites W2146876068 @default.
- W2810706768 cites W2153328565 @default.
- W2810706768 cites W2158217645 @default.
- W2810706768 cites W2160712706 @default.
- W2810706768 cites W2166523152 @default.
- W2810706768 cites W2166711199 @default.
- W2810706768 cites W2169923166 @default.
- W2810706768 cites W2181560004 @default.
- W2810706768 cites W2294442336 @default.
- W2810706768 cites W2347176161 @default.
- W2810706768 cites W2464204694 @default.
- W2810706768 cites W2464717012 @default.
- W2810706768 cites W2473552052 @default.
- W2810706768 cites W2492998196 @default.
- W2810706768 cites W2499478893 @default.
- W2810706768 cites W2513431601 @default.
- W2810706768 cites W2531012445 @default.
- W2810706768 cites W2550029420 @default.
- W2810706768 cites W2562328833 @default.