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- W2810731012 endingPage "46.e4" @default.
- W2810731012 startingPage "29" @default.
- W2810731012 abstract "Axonal protein synthesis and degradation are rapidly regulated by extrinsic signals during neural wiring, but the full landscape of proteomic changes remains unknown due to limitations in axon sampling and sensitivity. By combining pulsed stable isotope labeling of amino acids in cell culture with single-pot solid-phase-enhanced sample preparation, we characterized the nascent proteome of isolated retinal axons on an unparalleled rapid timescale (5 min). Our analysis detects 350 basally translated axonal proteins on average, including several linked to neurological disease. Axons stimulated by different cues (Netrin-1, BDNF, Sema3A) show distinct signatures with more than 100 different nascent protein species up- or downregulated within the first 5 min followed by further dynamic remodeling. Switching repulsion to attraction triggers opposite regulation of a subset of common nascent proteins. Our findings thus reveal the rapid remodeling of the axonal proteomic landscape by extrinsic cues and uncover a logic underlying attraction versus repulsion." @default.
- W2810731012 created "2018-07-10" @default.
- W2810731012 creator A5012387148 @default.
- W2810731012 creator A5031956637 @default.
- W2810731012 creator A5032036779 @default.
- W2810731012 creator A5079094223 @default.
- W2810731012 creator A5089091347 @default.
- W2810731012 date "2018-07-01" @default.
- W2810731012 modified "2023-10-17" @default.
- W2810731012 title "Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome" @default.
- W2810731012 cites W1528466095 @default.
- W2810731012 cites W1538641465 @default.
- W2810731012 cites W1569535372 @default.
- W2810731012 cites W1585637542 @default.
- W2810731012 cites W1596468514 @default.
- W2810731012 cites W1611891438 @default.
- W2810731012 cites W1626079339 @default.
- W2810731012 cites W1631059898 @default.
- W2810731012 cites W1825473355 @default.
- W2810731012 cites W1883988145 @default.
- W2810731012 cites W1937556537 @default.
- W2810731012 cites W1968358311 @default.
- W2810731012 cites W1972868257 @default.
- W2810731012 cites W1977802779 @default.
- W2810731012 cites W1985468501 @default.
- W2810731012 cites W1991545156 @default.
- W2810731012 cites W1993879896 @default.
- W2810731012 cites W1994088328 @default.
- W2810731012 cites W1995374378 @default.
- W2810731012 cites W1998254077 @default.
- W2810731012 cites W1998439494 @default.
- W2810731012 cites W2004153371 @default.
- W2810731012 cites W2010330233 @default.
- W2810731012 cites W2011769238 @default.
- W2810731012 cites W2012398393 @default.
- W2810731012 cites W2013398633 @default.
- W2810731012 cites W2024744542 @default.
- W2810731012 cites W2026731380 @default.
- W2810731012 cites W2026819189 @default.
- W2810731012 cites W2027415486 @default.
- W2810731012 cites W2028976114 @default.
- W2810731012 cites W2035313943 @default.
- W2810731012 cites W2035899716 @default.
- W2810731012 cites W2036950925 @default.
- W2810731012 cites W2039127036 @default.
- W2810731012 cites W2040537631 @default.
- W2810731012 cites W2047112279 @default.
- W2810731012 cites W2051434331 @default.
- W2810731012 cites W2060115989 @default.
- W2810731012 cites W2063252423 @default.
- W2810731012 cites W2064140502 @default.
- W2810731012 cites W2066029285 @default.
- W2810731012 cites W2072977612 @default.
- W2810731012 cites W2073569988 @default.
- W2810731012 cites W2074058520 @default.
- W2810731012 cites W2077416639 @default.
- W2810731012 cites W2080752012 @default.
- W2810731012 cites W2086295063 @default.
- W2810731012 cites W2086714676 @default.
- W2810731012 cites W2089419574 @default.
- W2810731012 cites W2090661905 @default.
- W2810731012 cites W2098677966 @default.
- W2810731012 cites W2108777463 @default.
- W2810731012 cites W2118125488 @default.
- W2810731012 cites W2120447586 @default.
- W2810731012 cites W2124348590 @default.
- W2810731012 cites W2128551987 @default.
- W2810731012 cites W2129959299 @default.
- W2810731012 cites W2129975664 @default.
- W2810731012 cites W2133948974 @default.
- W2810731012 cites W2135581618 @default.
- W2810731012 cites W2146512944 @default.
- W2810731012 cites W2156035149 @default.
- W2810731012 cites W2157162286 @default.
- W2810731012 cites W2168253930 @default.
- W2810731012 cites W2168958678 @default.
- W2810731012 cites W2169725112 @default.
- W2810731012 cites W2170949754 @default.
- W2810731012 cites W2171323620 @default.
- W2810731012 cites W2223296516 @default.
- W2810731012 cites W2257867940 @default.
- W2810731012 cites W2299008096 @default.
- W2810731012 cites W2303044895 @default.
- W2810731012 cites W2334665931 @default.
- W2810731012 cites W2338864125 @default.
- W2810731012 cites W2440302195 @default.
- W2810731012 cites W2537623931 @default.
- W2810731012 cites W2538212414 @default.
- W2810731012 cites W2538630917 @default.
- W2810731012 cites W2564412328 @default.
- W2810731012 cites W2569390976 @default.
- W2810731012 cites W2583152366 @default.
- W2810731012 cites W2626787163 @default.
- W2810731012 cites W2737782029 @default.
- W2810731012 cites W2745227215 @default.
- W2810731012 cites W2759929715 @default.
- W2810731012 cites W53544134 @default.
- W2810731012 doi "https://doi.org/10.1016/j.neuron.2018.06.004" @default.