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- W2810775583 abstract "We developed a versatile, rapid, and robust high-yielding radiochemistry-adapted protocol utilizing formamides as masking groups for secondary and tertiary amines. Selective reducing conditions were devised using borane reagents. In this protocol formamide functionalities were found to have an orthogonal reactivity to most other carbonyl functions, while effectively protecting amines from oxidative degradation. We exemplify the newly developed methodology by synthesizing a µ-opioid PET radiotracer and a phenethylamine PET radiotracer analogue." @default.
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- W2810775583 date "2018-07-19" @default.
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- W2810775583 title "Formamide as an Unconventional Amine Protecting Group for PET Radiochemistry" @default.
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- W2810775583 doi "https://doi.org/10.1002/ejoc.201800554" @default.
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