Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810810147> ?p ?o ?g. }
- W2810810147 abstract "We find that clusters of β4 integrin, organized into distinct puncta, localize along vimentin filaments within lamellipodia at the cell edge of A549 cells, as assessed by interferometric photoactivated localization microscopy. Moreover, puncta and vimentin filaments exhibit a dynamic interplay in live cells, as viewed by structured-illumination microscopy, with β4 integrin puncta that associate with vimentin persisting for longer than those that do not. Interestingly, in A549 cells β4 integrin regulates vimentin cytoskeleton organization. When β4 integrin is knocked down there is a loss of vimentin filaments from lamellipodia. However, in these conditions, vimentin filaments instead concentrate around the nucleus. Although β4 integrin organization is unaffected in vimentin-deficient A549 cells, such cells move in a less-directed fashion and exhibit reduced Rac1 activity, mimicking the phenotype of β4 integrin-deficient A549 cells. Moreover, in vimentin-deficient cells, Rac1 fails to cluster at sites enriched in α6β4 integrin heterodimers. The aberrant motility of both β4 integrin and vimentin-deficient cells is rescued by expression of active Rac1, leading us to propose that complexes of β4 integrin and vimentin act as signaling hubs, regulating cell motility behavior." @default.
- W2810810147 created "2018-07-10" @default.
- W2810810147 creator A5035402807 @default.
- W2810810147 creator A5083333830 @default.
- W2810810147 date "2018-01-01" @default.
- W2810810147 modified "2023-09-25" @default.
- W2810810147 title "Complexes of α6β4 integrin and vimentin signal to regulate epithelial cell migration" @default.
- W2810810147 cites W1522693266 @default.
- W2810810147 cites W1842994045 @default.
- W2810810147 cites W1907328278 @default.
- W2810810147 cites W1973137441 @default.
- W2810810147 cites W1976215621 @default.
- W2810810147 cites W1978985265 @default.
- W2810810147 cites W1984326475 @default.
- W2810810147 cites W1991815226 @default.
- W2810810147 cites W1994506188 @default.
- W2810810147 cites W2005918089 @default.
- W2810810147 cites W2009910883 @default.
- W2810810147 cites W2016083251 @default.
- W2810810147 cites W2024526152 @default.
- W2810810147 cites W2026186604 @default.
- W2810810147 cites W2027869188 @default.
- W2810810147 cites W2033681711 @default.
- W2810810147 cites W2033692697 @default.
- W2810810147 cites W2038835879 @default.
- W2810810147 cites W2044269802 @default.
- W2810810147 cites W2047796828 @default.
- W2810810147 cites W2053106661 @default.
- W2810810147 cites W2053300659 @default.
- W2810810147 cites W2055240903 @default.
- W2810810147 cites W2057646898 @default.
- W2810810147 cites W2067119107 @default.
- W2810810147 cites W2073051491 @default.
- W2810810147 cites W2085767196 @default.
- W2810810147 cites W2085781596 @default.
- W2810810147 cites W2089271523 @default.
- W2810810147 cites W2089898568 @default.
- W2810810147 cites W2101244168 @default.
- W2810810147 cites W2104082168 @default.
- W2810810147 cites W2105183595 @default.
- W2810810147 cites W2110436086 @default.
- W2810810147 cites W2114865203 @default.
- W2810810147 cites W2119734833 @default.
- W2810810147 cites W2126931729 @default.
- W2810810147 cites W2143339100 @default.
- W2810810147 cites W2143523073 @default.
- W2810810147 cites W2145809469 @default.
- W2810810147 cites W2147138972 @default.
- W2810810147 cites W2156155065 @default.
- W2810810147 cites W2160868856 @default.
- W2810810147 cites W2164700828 @default.
- W2810810147 cites W2167279371 @default.
- W2810810147 cites W2171339171 @default.
- W2810810147 cites W2171536147 @default.
- W2810810147 cites W2171855761 @default.
- W2810810147 cites W2182667971 @default.
- W2810810147 cites W2218922061 @default.
- W2810810147 cites W2262828252 @default.
- W2810810147 cites W2294538747 @default.
- W2810810147 cites W2300842584 @default.
- W2810810147 cites W2335973111 @default.
- W2810810147 cites W2339832393 @default.
- W2810810147 cites W2416705229 @default.
- W2810810147 cites W2517856915 @default.
- W2810810147 cites W2529052661 @default.
- W2810810147 cites W2574281994 @default.
- W2810810147 cites W2606405434 @default.
- W2810810147 cites W2802905010 @default.
- W2810810147 doi "https://doi.org/10.1242/jcs.214593" @default.
- W2810810147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6080603" @default.
- W2810810147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29976561" @default.
- W2810810147 hasPublicationYear "2018" @default.
- W2810810147 type Work @default.
- W2810810147 sameAs 2810810147 @default.
- W2810810147 citedByCount "28" @default.
- W2810810147 countsByYear W28108101472018 @default.
- W2810810147 countsByYear W28108101472019 @default.
- W2810810147 countsByYear W28108101472020 @default.
- W2810810147 countsByYear W28108101472021 @default.
- W2810810147 countsByYear W28108101472022 @default.
- W2810810147 countsByYear W28108101472023 @default.
- W2810810147 crossrefType "journal-article" @default.
- W2810810147 hasAuthorship W2810810147A5035402807 @default.
- W2810810147 hasAuthorship W2810810147A5083333830 @default.
- W2810810147 hasBestOaLocation W28108101471 @default.
- W2810810147 hasConcept C109185818 @default.
- W2810810147 hasConcept C125705527 @default.
- W2810810147 hasConcept C137738243 @default.
- W2810810147 hasConcept C142669718 @default.
- W2810810147 hasConcept C147447768 @default.
- W2810810147 hasConcept C1491633281 @default.
- W2810810147 hasConcept C195687474 @default.
- W2810810147 hasConcept C203014093 @default.
- W2810810147 hasConcept C204232928 @default.
- W2810810147 hasConcept C2779717556 @default.
- W2810810147 hasConcept C38676607 @default.
- W2810810147 hasConcept C55493867 @default.
- W2810810147 hasConcept C58207958 @default.
- W2810810147 hasConcept C62478195 @default.
- W2810810147 hasConcept C78383274 @default.