FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810819338> ?p ?o ?g. }

• W2810819338 endingPage "1851" @default.
• W2810819338 startingPage "1836" @default.
• W2810819338 abstract "Aim We performed acute and chronic studies in healthy and diet-induced obese animals using mouse-specific or monkey-specific dual GLP-1R/GCGR agonists to investigate their effects on food intake, body weight, blood glucose control and insulin secretion. The selective GLP-1R agonist liraglutide was used as comparator. Methods The mouse-specific dual agonist and liraglutide were tested in lean wild type, GLP-1R knockout and diet-induced obese mice at different doses. A chronic study was performed in DIO mice to investigate the effect on body weight, food consumption and total energy expenditure (TEE) in obese and diabetic monkeys with a focus on body weight and energy intake. Results The mouse-specific dual agonist and liraglutide similarly affected glycaemic control. A higher loss in body weight was measured in dual agonist-treated obese mice. The dual agonist significantly enhanced plasma glucose excursion in overnight fed GLP-1R−/− mice, probably reflecting a potent GCGR agonist activity. It increased TEE and enhanced fat and carbohydrate oxidation, while liraglutide produced no effect on TEE. In obese and diabetic monkeys, treatment with the monkey-specific dual agonist reduced total energy intake to 60%-70% of baseline TEI during chronic treatment. A decrease in body weight and significant improvement in glucose tolerance was observed. Conclusions In DIO mice and non-human primates, dual agonists elicited robust glycaemic control, similar to the marketed GLP-1R agonist, while eliciting greater effects on body weight. Results from DIO mice suggest that the increase in TEE is caused not only by increased fat oxidation but also by an increase in carbohydrate oxidation." @default.
• W2810819338 created "2018-07-10" @default.
• W2810819338 creator A5013669865 @default.
• W2810819338 creator A5014652724 @default.
• W2810819338 creator A5019559427 @default.
• W2810819338 creator A5023387444 @default.
• W2810819338 creator A5025554378 @default.
• W2810819338 creator A5028764581 @default.
• W2810819338 creator A5031894674 @default.
• W2810819338 creator A5042208848 @default.
• W2810819338 creator A5047123077 @default.
• W2810819338 creator A5060556419 @default.
• W2810819338 creator A5062311283 @default.
• W2810819338 creator A5067483337 @default.
• W2810819338 creator A5073494000 @default.
• W2810819338 creator A5078051333 @default.
• W2810819338 creator A5079590553 @default.
• W2810819338 creator A5086492738 @default.
• W2810819338 creator A5087774783 @default.
• W2810819338 date "2018-06-25" @default.
• W2810819338 modified "2023-10-17" @default.
• W2810819338 title "Running on mixed fuel-dual agonistic approach of GLP-1 and GCG receptors leads to beneficial impact on body weight and blood glucose control: A comparative study between mice and non-human primates" @default.
• W2810819338 cites W1572696163 @default.
• W2810819338 cites W1773084519 @default.
• W2810819338 cites W1975344770 @default.
• W2810819338 cites W1986331352 @default.
• W2810819338 cites W1989069545 @default.
• W2810819338 cites W1989616977 @default.
• W2810819338 cites W1990996794 @default.
• W2810819338 cites W1998666715 @default.
• W2810819338 cites W2002830269 @default.
• W2810819338 cites W2004690438 @default.
• W2810819338 cites W2008497683 @default.
• W2810819338 cites W2009181770 @default.
• W2810819338 cites W2009631652 @default.
• W2810819338 cites W2026149528 @default.
• W2810819338 cites W2028617804 @default.
• W2810819338 cites W2056430860 @default.
• W2810819338 cites W2081666098 @default.
• W2810819338 cites W2081848794 @default.
• W2810819338 cites W2084247271 @default.
• W2810819338 cites W2085655607 @default.
• W2810819338 cites W2098957321 @default.
• W2810819338 cites W2112573165 @default.
• W2810819338 cites W2115939390 @default.
• W2810819338 cites W2119446720 @default.
• W2810819338 cites W2122188063 @default.
• W2810819338 cites W2123578975 @default.
• W2810819338 cites W2131192628 @default.
• W2810819338 cites W2132295069 @default.
• W2810819338 cites W2135978651 @default.
• W2810819338 cites W2144166875 @default.
• W2810819338 cites W2148623180 @default.
• W2810819338 cites W2150622862 @default.
• W2810819338 cites W2154497567 @default.
• W2810819338 cites W2171857877 @default.
• W2810819338 cites W2377616525 @default.
• W2810819338 cites W2464238397 @default.
• W2810819338 cites W2471889258 @default.
• W2810819338 cites W2472736346 @default.
• W2810819338 cites W2528810881 @default.
• W2810819338 cites W2591832038 @default.
• W2810819338 cites W2608961189 @default.
• W2810819338 cites W3174811247 @default.
• W2810819338 cites W4245650535 @default.
• W2810819338 doi "https://doi.org/10.1111/dom.13212" @default.
• W2810819338 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6055720" @default.
• W2810819338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29938884" @default.
• W2810819338 hasPublicationYear "2018" @default.
• W2810819338 type Work @default.
• W2810819338 sameAs 2810819338 @default.
• W2810819338 citedByCount "23" @default.
• W2810819338 countsByYear W28108193382019 @default.
• W2810819338 countsByYear W28108193382020 @default.
• W2810819338 countsByYear W28108193382021 @default.
• W2810819338 countsByYear W28108193382022 @default.
• W2810819338 countsByYear W28108193382023 @default.
• W2810819338 crossrefType "journal-article" @default.
• W2810819338 hasAuthorship W2810819338A5013669865 @default.
• W2810819338 hasAuthorship W2810819338A5014652724 @default.
• W2810819338 hasAuthorship W2810819338A5019559427 @default.
• W2810819338 hasAuthorship W2810819338A5023387444 @default.
• W2810819338 hasAuthorship W2810819338A5025554378 @default.
• W2810819338 hasAuthorship W2810819338A5028764581 @default.
• W2810819338 hasAuthorship W2810819338A5031894674 @default.
• W2810819338 hasAuthorship W2810819338A5042208848 @default.
• W2810819338 hasAuthorship W2810819338A5047123077 @default.
• W2810819338 hasAuthorship W2810819338A5060556419 @default.
• W2810819338 hasAuthorship W2810819338A5062311283 @default.
• W2810819338 hasAuthorship W2810819338A5067483337 @default.
• W2810819338 hasAuthorship W2810819338A5073494000 @default.
• W2810819338 hasAuthorship W2810819338A5078051333 @default.
• W2810819338 hasAuthorship W2810819338A5079590553 @default.
• W2810819338 hasAuthorship W2810819338A5086492738 @default.
• W2810819338 hasAuthorship W2810819338A5087774783 @default.
• W2810819338 hasBestOaLocation W28108193381 @default.
• W2810819338 hasConcept C126322002 @default.
• W2810819338 hasConcept C134018914 @default.

• next