FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810823800> ?p ?o ?g. }

• W2810823800 endingPage "1198" @default.
• W2810823800 startingPage "1198" @default.
• W2810823800 abstract "<h3>Importance</h3> Identifing potential screening tests for future cognitive decline is a priority for developing treatments for and the prevention of dementia. <h3>Objective</h3> To examine the potential of retinal nerve fiber layer (RNFL) thickness measurement in identifying those at greater risk of cognitive decline in a large community cohort of healthy people. <h3>Design, Setting, and Participants</h3> UK Biobank is a prospective, multicenter, community-based study of UK residents aged 40 to 69 years at enrollment who underwent baseline retinal optical coherence tomography imaging, a physical examination, and a questionnaire. The pilot study phase was conducted from March 2006 to June 2006, and the main cohort underwent examination for baseline measures from April 2007 to October 2010. Four basic cognitive tests were performed at baseline, which were then repeated in a subset of participants approximately 3 years later. We analyzed eyes with high-quality optical coherence tomography images, excluding those with eye disease or vision loss, a history of ocular or neurological disease, or diabetes. We explored associations between RNFL thickness and cognitive function using multivariable logistic regression modeling to control for demographic as well as physiologic and ocular variation. <h3>Main Outcomes and Measures</h3> Odds ratios (ORs) for cognitive performance in the lowest fifth percentile in at least 2 of 4 cognitive tests at baseline, or worsening results on at least 1 cognitive test at follow-up. These analyses were adjusted for age, sex, race/ethnicity, height, refraction, intraocular pressure, education, and socioeconomic status. <h3>Results</h3> A total of 32 038 people were included at baseline testing, for whom the mean age was 56.0 years and of whom 17 172 (53.6%) were women. A thinner RNFL was associated with worse cognitive performance on baseline assessment. A multivariable regression controlling for potential confounders showed that those in the thinnest quintile of RNFL were 11% more likely to fail at least 1 cognitive test (95% CI, 2.0%-2.1%;<i>P</i> = .01). Follow-up cognitive tests were performed for 1251 participants (3.9%). Participants with an RNFL thickness in the 2 thinnest quintiles were almost twice as likely to have at least 1 test score be worse at follow-up cognitive testing (quintile 1: OR, 1.92; 95% CI, 1.29-2.85;<i>P</i> < .001; quintile 2: OR, 2.08; 95% CI, 1.40-3.08;<i>P</i> < .001). <h3>Conclusions and Relevance</h3> A thinner RNFL is associated with worse cognitive function in individuals without a neurodegenerative disease as well as greater likelihood of future cognitive decline. This preclinical observation has implications for future research, prevention, and treatment of dementia." @default.
• W2810823800 created "2018-07-10" @default.
• W2810823800 creator A5003259452 @default.
• W2810823800 creator A5008365841 @default.
• W2810823800 creator A5024065801 @default.
• W2810823800 creator A5035391535 @default.
• W2810823800 creator A5036476535 @default.
• W2810823800 creator A5060343222 @default.
• W2810823800 creator A5060591968 @default.
• W2810823800 creator A5061751725 @default.
• W2810823800 creator A5067795081 @default.
• W2810823800 creator A5069175872 @default.
• W2810823800 creator A5074881456 @default.
• W2810823800 creator A5076723676 @default.
• W2810823800 creator A5090428050 @default.
• W2810823800 date "2018-10-01" @default.
• W2810823800 modified "2023-10-16" @default.
• W2810823800 title "Association of Retinal Nerve Fiber Layer Thinning With Current and Future Cognitive Decline" @default.
• W2810823800 cites W1488074945 @default.
• W2810823800 cites W1507123469 @default.
• W2810823800 cites W1757234981 @default.
• W2810823800 cites W1898743042 @default.
• W2810823800 cites W1973526765 @default.
• W2810823800 cites W1974244012 @default.
• W2810823800 cites W1987919735 @default.
• W2810823800 cites W1988514407 @default.
• W2810823800 cites W2013107002 @default.
• W2810823800 cites W2023543027 @default.
• W2810823800 cites W2036732840 @default.
• W2810823800 cites W2066225757 @default.
• W2810823800 cites W2069812419 @default.
• W2810823800 cites W2071068165 @default.
• W2810823800 cites W2074730056 @default.
• W2810823800 cites W2075584671 @default.
• W2810823800 cites W2077039279 @default.
• W2810823800 cites W2082497158 @default.
• W2810823800 cites W2101934488 @default.
• W2810823800 cites W2107461385 @default.
• W2810823800 cites W2114192554 @default.
• W2810823800 cites W2120174187 @default.
• W2810823800 cites W2122320288 @default.
• W2810823800 cites W2157359173 @default.
• W2810823800 cites W2159419103 @default.
• W2810823800 cites W2171250577 @default.
• W2810823800 cites W2201344057 @default.
• W2810823800 cites W2286385206 @default.
• W2810823800 cites W2337889145 @default.
• W2810823800 cites W2339231197 @default.
• W2810823800 cites W2401147790 @default.
• W2810823800 cites W2418802570 @default.
• W2810823800 cites W2474900144 @default.
• W2810823800 cites W2529324783 @default.
• W2810823800 cites W2606944807 @default.
• W2810823800 cites W2767146355 @default.
• W2810823800 cites W3157419554 @default.
• W2810823800 doi "https://doi.org/10.1001/jamaneurol.2018.1578" @default.
• W2810823800 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6233846" @default.
• W2810823800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29946685" @default.
• W2810823800 hasPublicationYear "2018" @default.
• W2810823800 type Work @default.
• W2810823800 sameAs 2810823800 @default.
• W2810823800 citedByCount "126" @default.
• W2810823800 countsByYear W28108238002018 @default.
• W2810823800 countsByYear W28108238002019 @default.
• W2810823800 countsByYear W28108238002020 @default.
• W2810823800 countsByYear W28108238002021 @default.
• W2810823800 countsByYear W28108238002022 @default.
• W2810823800 countsByYear W28108238002023 @default.
• W2810823800 crossrefType "journal-article" @default.
• W2810823800 hasAuthorship W2810823800A5003259452 @default.
• W2810823800 hasAuthorship W2810823800A5008365841 @default.
• W2810823800 hasAuthorship W2810823800A5024065801 @default.
• W2810823800 hasAuthorship W2810823800A5035391535 @default.
• W2810823800 hasAuthorship W2810823800A5036476535 @default.
• W2810823800 hasAuthorship W2810823800A5060343222 @default.
• W2810823800 hasAuthorship W2810823800A5060591968 @default.
• W2810823800 hasAuthorship W2810823800A5061751725 @default.
• W2810823800 hasAuthorship W2810823800A5067795081 @default.
• W2810823800 hasAuthorship W2810823800A5069175872 @default.
• W2810823800 hasAuthorship W2810823800A5074881456 @default.
• W2810823800 hasAuthorship W2810823800A5076723676 @default.
• W2810823800 hasAuthorship W2810823800A5090428050 @default.
• W2810823800 hasBestOaLocation W28108238001 @default.
• W2810823800 hasConcept C118487528 @default.
• W2810823800 hasConcept C118552586 @default.
• W2810823800 hasConcept C126322002 @default.
• W2810823800 hasConcept C156957248 @default.
• W2810823800 hasConcept C169900460 @default.
• W2810823800 hasConcept C2778527774 @default.
• W2810823800 hasConcept C2779134260 @default.
• W2810823800 hasConcept C2779483572 @default.
• W2810823800 hasConcept C2780592520 @default.
• W2810823800 hasConcept C2984863031 @default.
• W2810823800 hasConcept C548259974 @default.
• W2810823800 hasConcept C6057870 @default.
• W2810823800 hasConcept C71924100 @default.
• W2810823800 hasConcept C72563966 @default.
• W2810823800 hasConceptScore W2810823800C118487528 @default.

• next