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• W2810831909 endingPage "318" @default.
• W2810831909 startingPage "318" @default.
• W2810831909 abstract "One of the most important features that enables Aspergillus fumigatus to grow within a susceptible individual and to cause disease is its ability to obtain Zn2+ ions from the extremely zinc-limited environment provided by host tissues. Zinc uptake from this source in A. fumigatus relies on ZIP transporters encoded by the zrfA, zrfB and zrfC genes. The expression of these genes is tightly regulated by the ZafA transcription factor that regulates zinc homeostasis and is essential for A. fumigatus virulence. We combined the use of microarrays, Electrophoretic Mobility Shift Assays (EMSA) analyses, DNase I footprinting assays and in silico tools to better understand the regulation of the homeostatic and adaptive response of A. fumigatus to zinc starvation. We found that under zinc-limiting conditions, ZafA functions mainly as a transcriptional activator through binding to a zinc response sequence located in the regulatory regions of its target genes, although it could also function as a repressor of a limited number of genes. In addition to genes involved in the homeostatic response to zinc deficiency, ZafA also influenced, either directly or indirectly, the expression of many other genes. It is remarkable that the expression of many genes involved in iron uptake and ergosterol biosynthesis is strongly reduced under zinc starvation, even though only the expression of some of these genes appeared to be influenced directly or indirectly by ZafA. In addition, it appears to exist in A. fumigatus a zinc/iron cross-homeostatic network to allow the adaptation of the fungus to grow in media containing unbalanced Zn:Fe ratios. The adaptive response to oxidative stress typically linked to zinc starvation was also mediated by ZafA, as was the strong induction of genes involved in gliotoxin biosynthesis and self-protection against endogenous gliotoxin. This study has expanded our knowledge about the regulatory and metabolic changes displayed by A. fumigatus in response to zinc starvation and has helped us to pinpoint new ZafA target genes that could be important for fungal pathogens to survive and grow within host tissues and, hence, for virulence." @default.
• W2810831909 created "2018-07-10" @default.
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• W2810831909 date "2018-06-26" @default.
• W2810831909 modified "2023-10-03" @default.
• W2810831909 title "The Transcription Factor ZafA Regulates the Homeostatic and Adaptive Response to Zinc Starvation in Aspergillus fumigatus" @default.
• W2810831909 cites W1493979308 @default.
• W2810831909 cites W1562463787 @default.
• W2810831909 cites W1563689661 @default.
• W2810831909 cites W1612987016 @default.
• W2810831909 cites W183036504 @default.
• W2810831909 cites W1915361649 @default.
• W2810831909 cites W1965204058 @default.
• W2810831909 cites W1965433629 @default.
• W2810831909 cites W1970985436 @default.
• W2810831909 cites W1973819022 @default.
• W2810831909 cites W1987374310 @default.
• W2810831909 cites W1987534706 @default.
• W2810831909 cites W1990830736 @default.
• W2810831909 cites W1993418715 @default.
• W2810831909 cites W1995972362 @default.
• W2810831909 cites W1997487743 @default.
• W2810831909 cites W1999766533 @default.
• W2810831909 cites W2002358035 @default.
• W2810831909 cites W2004300712 @default.
• W2810831909 cites W2004992298 @default.
• W2810831909 cites W2007636933 @default.
• W2810831909 cites W2008694461 @default.
• W2810831909 cites W2017186637 @default.
• W2810831909 cites W2020773912 @default.
• W2810831909 cites W2022862321 @default.
• W2810831909 cites W2029033126 @default.
• W2810831909 cites W2030115946 @default.
• W2810831909 cites W2032205265 @default.
• W2810831909 cites W2033400352 @default.
• W2810831909 cites W2037150792 @default.
• W2810831909 cites W2039330325 @default.
• W2810831909 cites W2044412059 @default.
• W2810831909 cites W2052498582 @default.
• W2810831909 cites W2056878292 @default.
• W2810831909 cites W2058564927 @default.
• W2810831909 cites W2061235822 @default.
• W2810831909 cites W2061338233 @default.
• W2810831909 cites W2066851086 @default.
• W2810831909 cites W2067189959 @default.
• W2810831909 cites W2071848825 @default.
• W2810831909 cites W2072054841 @default.
• W2810831909 cites W2072569496 @default.
• W2810831909 cites W2074005496 @default.
• W2810831909 cites W2075736354 @default.
• W2810831909 cites W2077007776 @default.
• W2810831909 cites W2077076461 @default.
• W2810831909 cites W2087364940 @default.
• W2810831909 cites W2089269684 @default.
• W2810831909 cites W2091225186 @default.
• W2810831909 cites W2092380192 @default.
• W2810831909 cites W2096629558 @default.
• W2810831909 cites W2097951289 @default.
• W2810831909 cites W2099224272 @default.
• W2810831909 cites W2106769310 @default.
• W2810831909 cites W2108313755 @default.
• W2810831909 cites W2112310296 @default.
• W2810831909 cites W2116798591 @default.
• W2810831909 cites W2117830545 @default.
• W2810831909 cites W2120454733 @default.
• W2810831909 cites W2130590948 @default.
• W2810831909 cites W2132291850 @default.
• W2810831909 cites W2137693232 @default.
• W2810831909 cites W2139102607 @default.
• W2810831909 cites W2145824148 @default.
• W2810831909 cites W2147558658 @default.
• W2810831909 cites W2157009395 @default.
• W2810831909 cites W2157177321 @default.
• W2810831909 cites W2160982898 @default.
• W2810831909 cites W2168157849 @default.
• W2810831909 cites W2168684404 @default.
• W2810831909 cites W2169784081 @default.
• W2810831909 cites W2194398512 @default.
• W2810831909 cites W2270923559 @default.
• W2810831909 cites W2343776672 @default.
• W2810831909 cites W2538285929 @default.
• W2810831909 cites W2795376785 @default.
• W2810831909 cites W4248606393 @default.
• W2810831909 doi "https://doi.org/10.3390/genes9070318" @default.
• W2810831909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6070888" @default.
• W2810831909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29949939" @default.
• W2810831909 hasPublicationYear "2018" @default.
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