Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810832877> ?p ?o ?g. }
- W2810832877 endingPage "2474" @default.
- W2810832877 startingPage "2459" @default.
- W2810832877 abstract "Phencyclidine (PCP, “angel dust”, an arylcyclohexylamine) was the first non-natural, man-made illicit drug of abuse, and was coined ‘the most dangerous drug in America” in the late 1970s (amidst sensational horror stories of the drug’s effects); however, few other illicit drugs have had such a significant and broad impact on society—both good and bad. Originally developed as a new class of anesthetic, PCP-derived psychosis gave way to the PCP hypothesis of schizophrenia (later coined the NMDA receptor hypofunction hypothesis or the glutamate hypothesis of schizophrenia), which continues to drive therapeutic discovery for schizophrenia today. PCP also led to the discovery of ketamine (and a new paradigm for the treatment of major depression), as well as other illicit, designer drugs, such as methoxetamine (MXE) and a new wave of Internet commerce for illicit drugs (sold as research chemicals, or RCs). Furthermore, PCP is a significant contaminant/additive of many illegal drugs sold today, due to its ease of preparation by clandestine chemists. Here, we will review the history, importance, synthesis (both legal and clandestine), pharmacology, drug metabolism, and folklore of PCP, a true DARK classic in chemical neuroscience." @default.
- W2810832877 created "2018-07-10" @default.
- W2810832877 creator A5022412820 @default.
- W2810832877 creator A5060483072 @default.
- W2810832877 creator A5077566010 @default.
- W2810832877 date "2018-06-28" @default.
- W2810832877 modified "2023-10-03" @default.
- W2810832877 title "DARK Classics in Chemical Neuroscience: Phencyclidine (PCP)" @default.
- W2810832877 cites W1467957441 @default.
- W2810832877 cites W14748109 @default.
- W2810832877 cites W1507804974 @default.
- W2810832877 cites W15515072 @default.
- W2810832877 cites W1589353809 @default.
- W2810832877 cites W1595187506 @default.
- W2810832877 cites W167817790 @default.
- W2810832877 cites W1920051648 @default.
- W2810832877 cites W1936652454 @default.
- W2810832877 cites W1967805565 @default.
- W2810832877 cites W1971145067 @default.
- W2810832877 cites W1978710583 @default.
- W2810832877 cites W1979201558 @default.
- W2810832877 cites W1980628262 @default.
- W2810832877 cites W1981234599 @default.
- W2810832877 cites W1982421314 @default.
- W2810832877 cites W1989397731 @default.
- W2810832877 cites W2003236216 @default.
- W2810832877 cites W2003512143 @default.
- W2810832877 cites W2003607000 @default.
- W2810832877 cites W2006248100 @default.
- W2810832877 cites W2007906244 @default.
- W2810832877 cites W2013514700 @default.
- W2810832877 cites W2013700944 @default.
- W2810832877 cites W2016995432 @default.
- W2810832877 cites W2022481449 @default.
- W2810832877 cites W2023081218 @default.
- W2810832877 cites W2023892570 @default.
- W2810832877 cites W2024380057 @default.
- W2810832877 cites W2025651868 @default.
- W2810832877 cites W2028884770 @default.
- W2810832877 cites W2030152904 @default.
- W2810832877 cites W2032184432 @default.
- W2810832877 cites W2033312613 @default.
- W2810832877 cites W2034455207 @default.
- W2810832877 cites W2035611331 @default.
- W2810832877 cites W2036454468 @default.
- W2810832877 cites W2038704879 @default.
- W2810832877 cites W2047563280 @default.
- W2810832877 cites W2048250261 @default.
- W2810832877 cites W2048251727 @default.
- W2810832877 cites W2053938654 @default.
- W2810832877 cites W2054741302 @default.
- W2810832877 cites W2055649644 @default.
- W2810832877 cites W2056342366 @default.
- W2810832877 cites W2057425334 @default.
- W2810832877 cites W2058795958 @default.
- W2810832877 cites W2059453991 @default.
- W2810832877 cites W2063464429 @default.
- W2810832877 cites W2063663134 @default.
- W2810832877 cites W2080867373 @default.
- W2810832877 cites W2087681850 @default.
- W2810832877 cites W2090642828 @default.
- W2810832877 cites W2094126290 @default.
- W2810832877 cites W2095097624 @default.
- W2810832877 cites W2097693079 @default.
- W2810832877 cites W2102506791 @default.
- W2810832877 cites W2102869925 @default.
- W2810832877 cites W2104456634 @default.
- W2810832877 cites W2105852576 @default.
- W2810832877 cites W2107099794 @default.
- W2810832877 cites W2109334244 @default.
- W2810832877 cites W2110735681 @default.
- W2810832877 cites W2112445212 @default.
- W2810832877 cites W2112492148 @default.
- W2810832877 cites W2116758557 @default.
- W2810832877 cites W2119166491 @default.
- W2810832877 cites W2120633269 @default.
- W2810832877 cites W2120812092 @default.
- W2810832877 cites W2124005257 @default.
- W2810832877 cites W2129311111 @default.
- W2810832877 cites W2137006494 @default.
- W2810832877 cites W2138368199 @default.
- W2810832877 cites W2140156016 @default.
- W2810832877 cites W2145185846 @default.
- W2810832877 cites W2145912576 @default.
- W2810832877 cites W2151898220 @default.
- W2810832877 cites W2154822242 @default.
- W2810832877 cites W2157160837 @default.
- W2810832877 cites W2158137297 @default.
- W2810832877 cites W2170029299 @default.
- W2810832877 cites W2278823400 @default.
- W2810832877 cites W2295989183 @default.
- W2810832877 cites W2300160852 @default.
- W2810832877 cites W2320537872 @default.
- W2810832877 cites W2413632320 @default.
- W2810832877 cites W2417158750 @default.
- W2810832877 cites W2468399841 @default.
- W2810832877 cites W2518980153 @default.
- W2810832877 cites W2607263420 @default.