Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810877710> ?p ?o ?g. }
- W2810877710 endingPage "1970" @default.
- W2810877710 startingPage "1957" @default.
- W2810877710 abstract "Aim: The modification of platelet inhibitor to enhance its targeting capacity toward platelets is of clinical importance. Thus, (1R, 3S)-1-methyl-1, 2, 3, 4-tetrahydro-β-carboline-3-carboxylic acid (MTCA), a platelet inhibitor, was modified with Lys(Pro-Ala-Lys)-Arg-Gly-Asp-Val (KKV), platelet targeting peptide, to form MTCA-KKV. Materials & methods: MTCA and MTCA-KKV were synthesized to identify the effect of KKV modification on MTCA and platelets. Results: Atomic force microscopy imaged MTCA-KKV effectively accumulated on activated platelets. UV spectra showed that MTCA-KKV concentration dependently changed P-selectin and GPIIb/IIIa conformations. For platelet aggregation, the IC 50 of MTCA-KKV was approximately 1/10 folds of MTCA. Conclusion: KKV modification led to forming MTCA-KKV that is superior to MTCA in terms of accumulating on activated platelets, targeting P-selectin and GPIIb/IIIa and inhibiting platelet aggregation. MTCA-KKV could be a promising lead for further investigation." @default.
- W2810877710 created "2018-07-10" @default.
- W2810877710 creator A5014271490 @default.
- W2810877710 creator A5024709912 @default.
- W2810877710 creator A5025640070 @default.
- W2810877710 creator A5029711969 @default.
- W2810877710 creator A5051045214 @default.
- W2810877710 creator A5062168574 @default.
- W2810877710 creator A5067273920 @default.
- W2810877710 creator A5072942807 @default.
- W2810877710 creator A5075411298 @default.
- W2810877710 creator A5077627175 @default.
- W2810877710 date "2018-08-01" @default.
- W2810877710 modified "2023-09-23" @default.
- W2810877710 title "Heptapeptide-based modification leading to enhancing the action of MTCA on activated platelets, P-selectin, GPIIb/IIIa" @default.
- W2810877710 cites W1854704635 @default.
- W2810877710 cites W1972333955 @default.
- W2810877710 cites W1973689793 @default.
- W2810877710 cites W1975572742 @default.
- W2810877710 cites W1975788394 @default.
- W2810877710 cites W1977262207 @default.
- W2810877710 cites W1987279269 @default.
- W2810877710 cites W1994595394 @default.
- W2810877710 cites W1996504648 @default.
- W2810877710 cites W2005419063 @default.
- W2810877710 cites W2008008383 @default.
- W2810877710 cites W2028419281 @default.
- W2810877710 cites W2039114630 @default.
- W2810877710 cites W2041760338 @default.
- W2810877710 cites W2048001922 @default.
- W2810877710 cites W2057710005 @default.
- W2810877710 cites W2074940126 @default.
- W2810877710 cites W2089599210 @default.
- W2810877710 cites W2091781936 @default.
- W2810877710 cites W2120590936 @default.
- W2810877710 cites W2154243361 @default.
- W2810877710 cites W2271255818 @default.
- W2810877710 cites W2414617114 @default.
- W2810877710 cites W2477158164 @default.
- W2810877710 cites W2511366155 @default.
- W2810877710 cites W2531185328 @default.
- W2810877710 cites W2544327228 @default.
- W2810877710 cites W2545046068 @default.
- W2810877710 cites W2555770175 @default.
- W2810877710 cites W2563801309 @default.
- W2810877710 cites W2568780221 @default.
- W2810877710 cites W2571911708 @default.
- W2810877710 cites W2590433286 @default.
- W2810877710 cites W2591857922 @default.
- W2810877710 cites W2601903984 @default.
- W2810877710 cites W2607133235 @default.
- W2810877710 cites W2607202920 @default.
- W2810877710 cites W2617469129 @default.
- W2810877710 cites W2619729093 @default.
- W2810877710 cites W2623859343 @default.
- W2810877710 cites W2627017849 @default.
- W2810877710 cites W2630907898 @default.
- W2810877710 cites W2737250552 @default.
- W2810877710 cites W2740064148 @default.
- W2810877710 cites W2746091150 @default.
- W2810877710 cites W2749945210 @default.
- W2810877710 cites W2750015175 @default.
- W2810877710 cites W2756258684 @default.
- W2810877710 cites W2757261965 @default.
- W2810877710 cites W2766249749 @default.
- W2810877710 cites W2766720610 @default.
- W2810877710 cites W2766886570 @default.
- W2810877710 cites W2770779648 @default.
- W2810877710 cites W2791712056 @default.
- W2810877710 cites W2520635462 @default.
- W2810877710 doi "https://doi.org/10.4155/fmc-2018-0055" @default.
- W2810877710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29973078" @default.
- W2810877710 hasPublicationYear "2018" @default.
- W2810877710 type Work @default.
- W2810877710 sameAs 2810877710 @default.
- W2810877710 citedByCount "2" @default.
- W2810877710 countsByYear W28108777102019 @default.
- W2810877710 countsByYear W28108777102022 @default.
- W2810877710 crossrefType "journal-article" @default.
- W2810877710 hasAuthorship W2810877710A5014271490 @default.
- W2810877710 hasAuthorship W2810877710A5024709912 @default.
- W2810877710 hasAuthorship W2810877710A5025640070 @default.
- W2810877710 hasAuthorship W2810877710A5029711969 @default.
- W2810877710 hasAuthorship W2810877710A5051045214 @default.
- W2810877710 hasAuthorship W2810877710A5062168574 @default.
- W2810877710 hasAuthorship W2810877710A5067273920 @default.
- W2810877710 hasAuthorship W2810877710A5072942807 @default.
- W2810877710 hasAuthorship W2810877710A5075411298 @default.
- W2810877710 hasAuthorship W2810877710A5077627175 @default.
- W2810877710 hasConcept C126322002 @default.
- W2810877710 hasConcept C185592680 @default.
- W2810877710 hasConcept C3018697912 @default.
- W2810877710 hasConcept C71924100 @default.
- W2810877710 hasConcept C89560881 @default.
- W2810877710 hasConcept C98274493 @default.
- W2810877710 hasConceptScore W2810877710C126322002 @default.
- W2810877710 hasConceptScore W2810877710C185592680 @default.
- W2810877710 hasConceptScore W2810877710C3018697912 @default.