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• W2810885280 endingPage "1742" @default.
• W2810885280 startingPage "1728" @default.
• W2810885280 abstract "Plants recruit positive and negative regulators for fine tuning the balance between growth and development. Negative regulators of pathogen defense generally modulate defense hormone biosynthesis and signaling. Here, we report a mechanism for attenuation of the defense response in Arabidopsis (Arabidopsis thaliana), which is mediated by the polycomb-group repressor MEDEA (MEA). Our results showed that pathogen inoculation or exogenous application of salicylic acid, methyl jasmonate, or the bacterial 22-amino acid domain of flagellin peptide induces the expression of MEAMEA expression was higher when plants were inoculated with the avirulent strain of Pseudomonas syringae pv. tomato (Pst) carrying the AvrRpt2 effector (Pst-AvrRpt2) compared to the virulent Pst strain. MEA remains suppressed during the vegetative phase via DNA and histone (H3K27) methylation, and only the maternal copy is expressed in the female gametophyte and endosperm via histone and DNA demethylation. In contrast, Pst-AvrRpt2 induces high levels of MEA expression via hyper-accumulation of H3K4me3 at the MEA locus. MEA-overexpressing transgenic plants are susceptible to the fungal pathogen Botrytis cinerea and bacterial pathogens Pst and Pst-AvrRpt2, whereas mea mutant plants are more resistant to bacterial pathogens. AvrRpt2-mediated immunity requires the function of RESISTANCE TO P. SYRINGAE2 (RPS2) in Arabidopsis. Using transcriptional analysis and chromatin immunoprecipitation, we established that MEA directly targets RPS2 and suppresses its transcription. We screened an Arabidopsis cDNA library using MEA as the bait in a yeast two-hybrid assay and identified DROUGHT-INDUCED19, a transcription factor that interacts with MEA and recruits it at the RPS2 promoter. The results identified a previously unknown mechanism of defense response attenuation in plants." @default.
• W2810885280 created "2018-07-10" @default.
• W2810885280 creator A5007307803 @default.
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• W2810885280 creator A5090050876 @default.
• W2810885280 date "2018-06-28" @default.
• W2810885280 modified "2023-10-14" @default.
• W2810885280 title "The Polycomb-Group Repressor MEDEA Attenuates Pathogen Defense" @default.
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• W2810885280 doi "https://doi.org/10.1104/pp.17.01579" @default.
• W2810885280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6084662" @default.
• W2810885280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29954867" @default.
• W2810885280 hasPublicationYear "2018" @default.
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