Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810900482> ?p ?o ?g. }
- W2810900482 abstract "Streptococcus pneumoniae is a Gram-positive bacterium that normally inhabits the human nasopharynx asymptomatically. However, it is also a major cause of pneumonia, bacteremia, and meningitis. The transition from pneumonia to bacteremia is critical, as patients that develop septicemia have ~20% mortality rates. Previous studies have shown that while neutrophils, a major bacterium-induced leukocyte, aid in S. pneumoniae elimination, they also contribute to pathology and may mediate the lung-to-blood passage of the bacteria. Herein, we show that epithelium-derived MRP1 and MRP2 efflux immunomodulatory agents that assist in controlling passage of neutrophils during infection and that limiting neutrophil infiltration produced less bacteremia and better survival during murine infection. The importance of our work is twofold: ours is the first to identify an MRP1/MRP2 axis of neutrophil control in the lung. The second is to provide possible therapeutic targets to reduce excess inflammation, thus reducing the chances of developing bacteremia during pneumococcal pneumonia." @default.
- W2810900482 created "2018-07-10" @default.
- W2810900482 creator A5002768937 @default.
- W2810900482 creator A5031816004 @default.
- W2810900482 creator A5037594187 @default.
- W2810900482 creator A5055102987 @default.
- W2810900482 creator A5068098793 @default.
- W2810900482 creator A5080210254 @default.
- W2810900482 date "2018-08-29" @default.
- W2810900482 modified "2023-10-16" @default.
- W2810900482 title "Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection" @default.
- W2810900482 cites W1500317768 @default.
- W2810900482 cites W1517877296 @default.
- W2810900482 cites W1519754251 @default.
- W2810900482 cites W1521262588 @default.
- W2810900482 cites W1527743177 @default.
- W2810900482 cites W1550704138 @default.
- W2810900482 cites W1600560134 @default.
- W2810900482 cites W1692613378 @default.
- W2810900482 cites W1958052624 @default.
- W2810900482 cites W1972202505 @default.
- W2810900482 cites W1975693150 @default.
- W2810900482 cites W1983491589 @default.
- W2810900482 cites W1988631824 @default.
- W2810900482 cites W1989918119 @default.
- W2810900482 cites W1993824829 @default.
- W2810900482 cites W2000980801 @default.
- W2810900482 cites W2005215061 @default.
- W2810900482 cites W2026786730 @default.
- W2810900482 cites W2035600812 @default.
- W2810900482 cites W2038519243 @default.
- W2810900482 cites W2058862680 @default.
- W2810900482 cites W2063629071 @default.
- W2810900482 cites W2084926273 @default.
- W2810900482 cites W2094761998 @default.
- W2810900482 cites W2102864904 @default.
- W2810900482 cites W2103656751 @default.
- W2810900482 cites W2105599787 @default.
- W2810900482 cites W2115003199 @default.
- W2810900482 cites W2117097280 @default.
- W2810900482 cites W2118434953 @default.
- W2810900482 cites W2119446930 @default.
- W2810900482 cites W2119974736 @default.
- W2810900482 cites W2128814422 @default.
- W2810900482 cites W2129949844 @default.
- W2810900482 cites W2131907316 @default.
- W2810900482 cites W2133953922 @default.
- W2810900482 cites W2136138987 @default.
- W2810900482 cites W2137331279 @default.
- W2810900482 cites W2141597037 @default.
- W2810900482 cites W2145969791 @default.
- W2810900482 cites W2147686705 @default.
- W2810900482 cites W2148243778 @default.
- W2810900482 cites W2148247163 @default.
- W2810900482 cites W2153886170 @default.
- W2810900482 cites W2156710340 @default.
- W2810900482 cites W2157941386 @default.
- W2810900482 cites W2163301152 @default.
- W2810900482 cites W2164708410 @default.
- W2810900482 cites W2167395319 @default.
- W2810900482 cites W2167697317 @default.
- W2810900482 cites W2170900491 @default.
- W2810900482 cites W2262630478 @default.
- W2810900482 cites W40933246 @default.
- W2810900482 doi "https://doi.org/10.1128/msphere.00303-18" @default.
- W2810900482 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6034076" @default.
- W2810900482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29976647" @default.
- W2810900482 hasPublicationYear "2018" @default.
- W2810900482 type Work @default.
- W2810900482 sameAs 2810900482 @default.
- W2810900482 citedByCount "6" @default.
- W2810900482 countsByYear W28109004822019 @default.
- W2810900482 countsByYear W28109004822021 @default.
- W2810900482 countsByYear W28109004822022 @default.
- W2810900482 countsByYear W28109004822023 @default.
- W2810900482 crossrefType "journal-article" @default.
- W2810900482 hasAuthorship W2810900482A5002768937 @default.
- W2810900482 hasAuthorship W2810900482A5031816004 @default.
- W2810900482 hasAuthorship W2810900482A5037594187 @default.
- W2810900482 hasAuthorship W2810900482A5055102987 @default.
- W2810900482 hasAuthorship W2810900482A5068098793 @default.
- W2810900482 hasAuthorship W2810900482A5080210254 @default.
- W2810900482 hasBestOaLocation W28109004821 @default.
- W2810900482 hasConcept C118552586 @default.
- W2810900482 hasConcept C126322002 @default.
- W2810900482 hasConcept C203014093 @default.
- W2810900482 hasConcept C2776345407 @default.
- W2810900482 hasConcept C2776914184 @default.
- W2810900482 hasConcept C2777714996 @default.
- W2810900482 hasConcept C2777914695 @default.
- W2810900482 hasConcept C2778384902 @default.
- W2810900482 hasConcept C2779443120 @default.
- W2810900482 hasConcept C2779892413 @default.
- W2810900482 hasConcept C2781026528 @default.
- W2810900482 hasConcept C2781253189 @default.
- W2810900482 hasConcept C501593827 @default.
- W2810900482 hasConcept C71924100 @default.
- W2810900482 hasConcept C86803240 @default.
- W2810900482 hasConcept C89423630 @default.
- W2810900482 hasConceptScore W2810900482C118552586 @default.