Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810902145> ?p ?o ?g. }
- W2810902145 endingPage "C356" @default.
- W2810902145 startingPage "C343" @default.
- W2810902145 abstract "The blood-brain barrier (BBB) is a physical and biochemical barrier that precisely controls cerebral homeostasis. It also plays a central role in the regulation of blood-to-brain flux of endogenous and exogenous xenobiotics and associated metabolites. This is accomplished by molecular characteristics of brain microvessel endothelial cells such as tight junction protein complexes and functional expression of influx and efflux transporters. One of the pathophysiological features of ischemic stroke is disruption of the BBB, which significantly contributes to development of brain injury and subsequent neurological impairment. Biochemical characteristics of BBB damage include decreased expression and altered organization of tight junction constituent proteins as well as modulation of functional expression of endogenous BBB transporters. Therefore, there is a critical need for development of novel therapeutic strategies that can protect against BBB dysfunction (i.e., vascular protection) in the setting of ischemic stroke. Such strategies include targeting tight junctions to ensure that they maintain their correct structure or targeting transporters to control flux of physiological substrates for protection of endothelial homeostasis. In this review, we will describe the pathophysiological mechanisms in cerebral microvascular endothelial cells that lead to BBB dysfunction following onset of stroke. Additionally, we will utilize this state-of-the-art knowledge to provide insights on novel pharmacological strategies that can be developed to confer BBB protection in the setting of ischemic stroke." @default.
- W2810902145 created "2018-07-10" @default.
- W2810902145 creator A5026720235 @default.
- W2810902145 creator A5038291181 @default.
- W2810902145 creator A5070658777 @default.
- W2810902145 date "2018-09-01" @default.
- W2810902145 modified "2023-10-14" @default.
- W2810902145 title "Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection" @default.
- W2810902145 cites W1486779292 @default.
- W2810902145 cites W1547339950 @default.
- W2810902145 cites W1596157971 @default.
- W2810902145 cites W163988335 @default.
- W2810902145 cites W174770600 @default.
- W2810902145 cites W1774426949 @default.
- W2810902145 cites W1882050418 @default.
- W2810902145 cites W1886326176 @default.
- W2810902145 cites W1946941723 @default.
- W2810902145 cites W1963766511 @default.
- W2810902145 cites W1965522214 @default.
- W2810902145 cites W1966178564 @default.
- W2810902145 cites W1968214306 @default.
- W2810902145 cites W1968425502 @default.
- W2810902145 cites W1969116648 @default.
- W2810902145 cites W1969794746 @default.
- W2810902145 cites W1971901938 @default.
- W2810902145 cites W1971940899 @default.
- W2810902145 cites W1972975985 @default.
- W2810902145 cites W1973070600 @default.
- W2810902145 cites W1975412808 @default.
- W2810902145 cites W1980869901 @default.
- W2810902145 cites W1981086261 @default.
- W2810902145 cites W1981425827 @default.
- W2810902145 cites W1983348654 @default.
- W2810902145 cites W1985455477 @default.
- W2810902145 cites W1988492326 @default.
- W2810902145 cites W1989764182 @default.
- W2810902145 cites W1996328429 @default.
- W2810902145 cites W1996558604 @default.
- W2810902145 cites W1997574458 @default.
- W2810902145 cites W1999959667 @default.
- W2810902145 cites W2000351290 @default.
- W2810902145 cites W2001658740 @default.
- W2810902145 cites W2002269747 @default.
- W2810902145 cites W2003183247 @default.
- W2810902145 cites W2003633558 @default.
- W2810902145 cites W2003962390 @default.
- W2810902145 cites W2003979057 @default.
- W2810902145 cites W2005130936 @default.
- W2810902145 cites W2005675003 @default.
- W2810902145 cites W2008518851 @default.
- W2810902145 cites W2008640695 @default.
- W2810902145 cites W2011554900 @default.
- W2810902145 cites W2012700090 @default.
- W2810902145 cites W2013260733 @default.
- W2810902145 cites W2015541518 @default.
- W2810902145 cites W2016212019 @default.
- W2810902145 cites W2016423457 @default.
- W2810902145 cites W2022489634 @default.
- W2810902145 cites W2022642913 @default.
- W2810902145 cites W2025372996 @default.
- W2810902145 cites W2025688778 @default.
- W2810902145 cites W2026822427 @default.
- W2810902145 cites W2028858227 @default.
- W2810902145 cites W2030662122 @default.
- W2810902145 cites W2030982986 @default.
- W2810902145 cites W2031263000 @default.
- W2810902145 cites W2032150209 @default.
- W2810902145 cites W2033052141 @default.
- W2810902145 cites W2035221144 @default.
- W2810902145 cites W2038322652 @default.
- W2810902145 cites W2040645020 @default.
- W2810902145 cites W2042996709 @default.
- W2810902145 cites W2044033221 @default.
- W2810902145 cites W2044401686 @default.
- W2810902145 cites W2046711679 @default.
- W2810902145 cites W2049472148 @default.
- W2810902145 cites W2050533098 @default.
- W2810902145 cites W2051617804 @default.
- W2810902145 cites W2051709012 @default.
- W2810902145 cites W2053288552 @default.
- W2810902145 cites W2053657477 @default.
- W2810902145 cites W2055881161 @default.
- W2810902145 cites W2057717695 @default.
- W2810902145 cites W2058728855 @default.
- W2810902145 cites W2062478419 @default.
- W2810902145 cites W2065747229 @default.
- W2810902145 cites W2066123672 @default.
- W2810902145 cites W2067471997 @default.
- W2810902145 cites W2067733328 @default.
- W2810902145 cites W2069473580 @default.
- W2810902145 cites W2071932055 @default.
- W2810902145 cites W2072172632 @default.
- W2810902145 cites W2074983104 @default.
- W2810902145 cites W2075877825 @default.
- W2810902145 cites W2079785947 @default.
- W2810902145 cites W2079966013 @default.
- W2810902145 cites W2080013552 @default.
- W2810902145 cites W2080938528 @default.