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• W2810917708 abstract "Current clinical trials demonstrate Duchenne muscular dystrophy (DMD) patients receiving phosphorodiamidate morpholino oligomer (PMO) therapy exhibit improved ambulation and stable pulmonary function; however, cardiac abnormalities remain. Utilizing the same PMO chemistry as current clinical trials, we have identified a non-toxic PMO treatment regimen that restores metabolic activity and prevents DMD cardiomyopathy. We propose that a treatment regimen of this nature may have the potential to significantly improve morbidity and mortality from DMD by improving ambulation, stabilizing pulmonary function, and preventing the development of cardiomyopathy." @default.
• W2810917708 created "2018-07-10" @default.
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• W2810917708 date "2018-06-01" @default.
• W2810917708 modified "2023-09-27" @default.
• W2810917708 title "A Morpholino Oligomer Therapy Regime That Restores Mitochondrial Function and Prevents mdx Cardiomyopathy" @default.
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• W2810917708 doi "https://doi.org/10.1016/j.jacbts.2018.03.007" @default.
• W2810917708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6059013" @default.
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