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• W2810934503 abstract "Objective: To evaluate the clinical presentation of both patients with herpetic encephalitis (HE) and those with Neurological Conditions which are Not typically associated with HSV (NCNH), and to propose physiopathological explanations to the presence of HSV in CSF in both situations. Background: Herpes Simplex Viruses (HSV) have been commonly associated with diverse neurological conditions. However, some NCNH can also present with a positive PCR in CSF, whose significance is uncertain. Design/Methods: 1590 HSV PCR studies were reviewed. A retrospective analysis evaluating clinical presentation, workup (MRI, EEG and CSF-analysis) and outcome of 73 patients with HSV positive PCR in CSF was conducted during the period Jan 2007–Sep 2015 in our institution. Patients U18 and those with non-encephalitic HSV conditions were excluded. A group comparison between HE and NCNH patients was conducted using parametric/non parametric tests accordingly. Results: Sixteen patients with HE and 23 with NCNH were included (n=7 neuroimmunological, n=6 infectious, n=2 toxic-metabolic, n=2 neuro-oncological and n=4 unclassifiable causes). HE patients presented a higher incidence of headache/meningeal symptoms (87.5% and 50%; p Conclusions: HSV shows no clear pathogenic role among a considerable number of patients with a positive PCR result in CSF. This finding has to be evaluated in the context of their clinical background and workup. Immunocompromise and neuroinflammation conditions could be related to a higher presence of HSV in CSF. Disclosure: Dr. Alessandro has nothing to disclose. Dr. Wilken has nothing to disclose. Dr. Farez has received research support from Novartis Argentina. Dr. Kohler has received personal compensation for activities with Novartis Argentina and MERCK Argentina. Dr. Arias Cebollada has nothing to disclose. Dr. Mora has nothing to disclose. Dr. Cammarota has nothing to disclose. Dr. Del Castillo has nothing to disclose." @default.
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• W2810934503 date "2017-04-18" @default.
• W2810934503 modified "2023-09-23" @default.
• W2810934503 title "Herpes Simplex positive PCR in Cerebrospinal Fluid: physiopathological role in adult patients (P3.302)" @default.
• W2810934503 hasPublicationYear "2017" @default.
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