Matches in SemOpenAlex for { <https://semopenalex.org/work/W2810944049> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2810944049 abstract "In this thesis, we show the role of secondary structures in the 5’UTR of Igbp1 in its translation. We found that the structures had a slight IRES activity. Some ribosomes may be able to bypass (shunt) the Igbp1 5’UTR. Furthermore, during iron deficiency, HRI is activated and phosphorylates eIF2. In this thesis, we investigated genome-wide mRNA translation in response to proteotoxic stress by performing ribosome profiling in erythroblasts. We found an increased ribosome density for 147 transcripts during proteotoxic stress. We found that knockdown of Tis7 yielded 338 differentially expressed. In addition, we treated erythroblasts with Tm for 4 and 8 hours to investigate which targets may be regulated by Tis7 during proteotoxic stress. During Tm treatment, the loss of Tis7 led to differential expression of 33 genes, some of which are components of the translation machinery and some long non-coding RNAs. In addition, also the availability of ribosomes is crucial for erythropoiesis. In this thesis we investigated two cases with mutations in the RPS23 gene. We found that the Arg67Lys mutation impaired yeast growth and led to a reduction in 40S subunits in human cells. The mutation did not affect protein synthesis in human cells. Additionally, the Arg67Lys mutation impaired hydroxylation of a proline residue at position 62. In addition, the Phe120Ile mutation resulted in disruption of a predicted interaction between two phenylalanine residues which led to unstable RPS23. Furthermore, these RPS23 mutations impaired mRNA translation accuracy and exhibited an increased stress granule accumulation during oxidative stress." @default.
- W2810944049 created "2018-07-10" @default.
- W2810944049 creator A5020446823 @default.
- W2810944049 date "2018-01-01" @default.
- W2810944049 modified "2023-09-27" @default.
- W2810944049 title "Control of mRNA translation in erythroid cells" @default.
- W2810944049 hasPublicationYear "2018" @default.
- W2810944049 type Work @default.
- W2810944049 sameAs 2810944049 @default.
- W2810944049 citedByCount "0" @default.
- W2810944049 crossrefType "journal-article" @default.
- W2810944049 hasAuthorship W2810944049A5020446823 @default.
- W2810944049 hasConcept C104317684 @default.
- W2810944049 hasConcept C105580179 @default.
- W2810944049 hasConcept C117838200 @default.
- W2810944049 hasConcept C12464233 @default.
- W2810944049 hasConcept C149364088 @default.
- W2810944049 hasConcept C153911025 @default.
- W2810944049 hasConcept C173396325 @default.
- W2810944049 hasConcept C182325514 @default.
- W2810944049 hasConcept C3675279 @default.
- W2810944049 hasConcept C54355233 @default.
- W2810944049 hasConcept C67705224 @default.
- W2810944049 hasConcept C86803240 @default.
- W2810944049 hasConcept C88478588 @default.
- W2810944049 hasConcept C89604277 @default.
- W2810944049 hasConcept C95444343 @default.
- W2810944049 hasConceptScore W2810944049C104317684 @default.
- W2810944049 hasConceptScore W2810944049C105580179 @default.
- W2810944049 hasConceptScore W2810944049C117838200 @default.
- W2810944049 hasConceptScore W2810944049C12464233 @default.
- W2810944049 hasConceptScore W2810944049C149364088 @default.
- W2810944049 hasConceptScore W2810944049C153911025 @default.
- W2810944049 hasConceptScore W2810944049C173396325 @default.
- W2810944049 hasConceptScore W2810944049C182325514 @default.
- W2810944049 hasConceptScore W2810944049C3675279 @default.
- W2810944049 hasConceptScore W2810944049C54355233 @default.
- W2810944049 hasConceptScore W2810944049C67705224 @default.
- W2810944049 hasConceptScore W2810944049C86803240 @default.
- W2810944049 hasConceptScore W2810944049C88478588 @default.
- W2810944049 hasConceptScore W2810944049C89604277 @default.
- W2810944049 hasConceptScore W2810944049C95444343 @default.
- W2810944049 hasLocation W28109440491 @default.
- W2810944049 hasOpenAccess W2810944049 @default.
- W2810944049 hasPrimaryLocation W28109440491 @default.
- W2810944049 hasRelatedWork W1564742523 @default.
- W2810944049 hasRelatedWork W1974650295 @default.
- W2810944049 hasRelatedWork W1988575331 @default.
- W2810944049 hasRelatedWork W1989873806 @default.
- W2810944049 hasRelatedWork W2015803078 @default.
- W2810944049 hasRelatedWork W2016975585 @default.
- W2810944049 hasRelatedWork W2059474870 @default.
- W2810944049 hasRelatedWork W2086803695 @default.
- W2810944049 hasRelatedWork W2103961722 @default.
- W2810944049 hasRelatedWork W2140951250 @default.
- W2810944049 hasRelatedWork W2143798060 @default.
- W2810944049 hasRelatedWork W2166516791 @default.
- W2810944049 hasRelatedWork W2399870116 @default.
- W2810944049 hasRelatedWork W2416347695 @default.
- W2810944049 hasRelatedWork W2530894630 @default.
- W2810944049 hasRelatedWork W2531132675 @default.
- W2810944049 hasRelatedWork W2548087847 @default.
- W2810944049 hasRelatedWork W2806887154 @default.
- W2810944049 hasRelatedWork W3159843094 @default.
- W2810944049 hasRelatedWork W90430858 @default.
- W2810944049 isParatext "false" @default.
- W2810944049 isRetracted "false" @default.
- W2810944049 magId "2810944049" @default.
- W2810944049 workType "article" @default.