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- W2810960090 endingPage "1740" @default.
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- W2810960090 abstract "The classical development of drugs has progressively faded away, and we are currently in an era of seamless drug-development, where first-in-human trials include unusually big expansion cohorts in the search for early signs of activity and rapid regulatory approval. The fierce competition between different pharmaceutical companies and the hype for immune combinations obliges us to question the current way in which we are evaluating these drugs. In this review, we discuss critical issues and caveats in immunotherapy development. A particular emphasis is put on the limitations of pre-clinical toxicology studies, where both murine models and cynomolgus monkeys have underpredicted toxicity in humans. Moreover, relevant issues surrounding dose determination during phase I trials, such as dose–escalation methods or flat versus body-weight dosing, are discussed. A proposal of how to face these different challenges is offered, in order to achieve maximum efficacy with minimum toxicity for our patients." @default.
- W2810960090 created "2018-07-10" @default.
- W2810960090 creator A5013760636 @default.
- W2810960090 creator A5054682698 @default.
- W2810960090 creator A5058642751 @default.
- W2810960090 creator A5075296860 @default.
- W2810960090 creator A5076983415 @default.
- W2810960090 creator A5078720953 @default.
- W2810960090 date "2018-08-01" @default.
- W2810960090 modified "2023-10-18" @default.
- W2810960090 title "Early-drug development in the era of immuno-oncology: are we ready to face the challenges?" @default.
- W2810960090 cites W1490736032 @default.
- W2810960090 cites W1920235745 @default.
- W2810960090 cites W1981421409 @default.
- W2810960090 cites W1982093899 @default.
- W2810960090 cites W1990675339 @default.
- W2810960090 cites W1993519240 @default.
- W2810960090 cites W2000294386 @default.
- W2810960090 cites W2005475183 @default.
- W2810960090 cites W2006972833 @default.
- W2810960090 cites W2016983859 @default.
- W2810960090 cites W2027613914 @default.
- W2810960090 cites W2035971989 @default.
- W2810960090 cites W2041672829 @default.
- W2810960090 cites W2045478673 @default.
- W2810960090 cites W2045985885 @default.
- W2810960090 cites W2054383376 @default.
- W2810960090 cites W2076108528 @default.
- W2810960090 cites W2083997199 @default.
- W2810960090 cites W2087880917 @default.
- W2810960090 cites W2093838072 @default.
- W2810960090 cites W2094366129 @default.
- W2810960090 cites W2094901950 @default.
- W2810960090 cites W2097995306 @default.
- W2810960090 cites W2099609050 @default.
- W2810960090 cites W2103170395 @default.
- W2810960090 cites W2109465910 @default.
- W2810960090 cites W2109653150 @default.
- W2810960090 cites W2115499099 @default.
- W2810960090 cites W2118952409 @default.
- W2810960090 cites W2118982164 @default.
- W2810960090 cites W2124427232 @default.
- W2810960090 cites W2128758225 @default.
- W2810960090 cites W2133075384 @default.
- W2810960090 cites W2134638467 @default.
- W2810960090 cites W2141989396 @default.
- W2810960090 cites W2143467222 @default.
- W2810960090 cites W2145350167 @default.
- W2810960090 cites W2148706732 @default.
- W2810960090 cites W2150048477 @default.
- W2810960090 cites W2152980179 @default.
- W2810960090 cites W2160834915 @default.
- W2810960090 cites W2161550811 @default.
- W2810960090 cites W2165096463 @default.
- W2810960090 cites W2166045197 @default.
- W2810960090 cites W2166980833 @default.
- W2810960090 cites W2167228337 @default.
- W2810960090 cites W2183144139 @default.
- W2810960090 cites W2198093519 @default.
- W2810960090 cites W2210453860 @default.
- W2810960090 cites W2218204925 @default.
- W2810960090 cites W2233779237 @default.
- W2810960090 cites W2276555358 @default.
- W2810960090 cites W2289712604 @default.
- W2810960090 cites W2290349987 @default.
- W2810960090 cites W2293531514 @default.
- W2810960090 cites W2308363199 @default.
- W2810960090 cites W2340435799 @default.
- W2810960090 cites W2346108121 @default.
- W2810960090 cites W2414977199 @default.
- W2810960090 cites W2471132813 @default.
- W2810960090 cites W2516271598 @default.
- W2810960090 cites W2526282664 @default.
- W2810960090 cites W2528124008 @default.
- W2810960090 cites W2531874455 @default.
- W2810960090 cites W2532087281 @default.
- W2810960090 cites W2537734913 @default.
- W2810960090 cites W2549531711 @default.
- W2810960090 cites W2554947920 @default.
- W2810960090 cites W2567564314 @default.
- W2810960090 cites W2567691834 @default.
- W2810960090 cites W2585362372 @default.
- W2810960090 cites W2586405436 @default.
- W2810960090 cites W2587318636 @default.
- W2810960090 cites W2591306501 @default.
- W2810960090 cites W2594802329 @default.
- W2810960090 cites W2597811717 @default.
- W2810960090 cites W2602907503 @default.
- W2810960090 cites W2603690292 @default.
- W2810960090 cites W2612703804 @default.
- W2810960090 cites W2615652585 @default.
- W2810960090 cites W2618256759 @default.
- W2810960090 cites W2624341173 @default.
- W2810960090 cites W2741119937 @default.
- W2810960090 cites W2741564119 @default.
- W2810960090 cites W2746991247 @default.
- W2810960090 cites W2754555242 @default.
- W2810960090 cites W2754725540 @default.