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- W2810998977 endingPage "54" @default.
- W2810998977 startingPage "54" @default.
- W2810998977 abstract "There are many types of cell death, each involving multiple and complex molecular events. Cell death can occur accidentally when exposed to extreme physical, chemical, or mechanical conditions, or it can also be regulated, which involves a genetically coded complex machinery to carry out the process. Apoptosis is an example of the latter. Apoptotic cell death can be triggered through different intracellular signalling pathways that lead to morphological changes and eventually cell death. This is a normal and biological process carried out during maturation, remodelling, growth, and development in tissues. To maintain tissue homeostasis, regulatory, and inhibitory mechanisms must control apoptosis. Paradoxically, these same pathways are utilized during infection by distinct intracellular microorganisms to evade recognition by the immune system and therefore survive, reproduce and develop. In cancer, neoplastic cells inhibit apoptosis, thus allowing their survival and increasing their capability to invade different tissues and organs. The purpose of this work is to review the generalities of the molecular mechanisms and signalling pathways involved in apoptosis induction and inhibition. Additionally, we compile the current evidence of apoptosis modulation during cancer and Leishmania infection as a model of apoptosis regulation by an intracellular microorganism." @default.
- W2810998977 created "2018-07-10" @default.
- W2810998977 creator A5000691896 @default.
- W2810998977 creator A5005602909 @default.
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- W2810998977 creator A5049388193 @default.
- W2810998977 creator A5054190489 @default.
- W2810998977 date "2018-07-04" @default.
- W2810998977 modified "2023-10-17" @default.
- W2810998977 title "Apoptosis: Activation and Inhibition in Health and Disease" @default.
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