FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2811041349> ?p ?o ?g. }

• W2811041349 abstract "Heart-sparing techniques are time and resource intensive, although not all patients require the use of these strategies. This study evaluates the performance of different distance metrics in predicting the need for breath-hold radiotherapy in left-sided breast cancer patients receiving adjuvant radiotherapy. Fifty left-sided breast cancer patients treated with breast conserving surgery and adjuvant radiotherapy to the breast from a single institution were retrospectively studied. The left breast and organs at risk were contoured in accordance to guidelines and a plan with tangents was obtained using the free-breathing CT in supine position. Heart (mean heart dose (MHD), heart V25 Gy) and left anterior descending artery dosimetry were computed and compared against distance metrics under investigation (Contact Heart, 4th Arch and 5th Arch). Recursive partitioning analysis (RPA) was used to determine optimal cut-points for distance metrics for dosimetric end points. Receiver operating characteristic curves and Pearson correlation coefficients were used to evaluate the association between distance metrics and dosimetric endpoints. Univariable and multivariable logistic regression analysis was performed to identify significant predictors of dosimetric end points. The mean MHD and heart V25 Gy were 2.3 Gy and 10.4 cm3, respectively. With tangents, constraints for MHD (< 1.7 Gy and V25 Gy < 10 cm3) were unattainable in 80% and 46% of patients, respectively. Optimal RPA thresholds included: Contact Heart (73 mm), 4th Arch (7 mm) and 5th Arch (41 mm). Of these, the 4th Arch had the highest overall accuracy, sensitivity, concordance index and correlation coefficient. All metrics were statistically significant predictors for MHD ≥ 1.7 Gy based on univariable logistic regression. Fifth Arch did not reach significance for heart V25 Gy ≥ 10 cm3. Fourth Arch was the only predictor to remain statistically significant after multivariable analysis. We propose a novel “4th Arch” metric as an accurate and practical tool to determine the need for breath-hold radiotherapy for left-sided breast cancer patients undergoing adjuvant radiotherapy with standard tangents. Further validation in an external cohort is necessary." @default.
• W2811041349 created "2018-07-10" @default.
• W2811041349 creator A5000161940 @default.
• W2811041349 creator A5012945339 @default.
• W2811041349 creator A5016085567 @default.
• W2811041349 creator A5017024734 @default.
• W2811041349 creator A5038486476 @default.
• W2811041349 creator A5057188360 @default.
• W2811041349 creator A5060617607 @default.
• W2811041349 creator A5068878236 @default.
• W2811041349 creator A5070892204 @default.
• W2811041349 creator A5071660222 @default.
• W2811041349 creator A5083773941 @default.
• W2811041349 date "2018-07-04" @default.
• W2811041349 modified "2023-09-24" @default.
• W2811041349 title "Evaluation of a new predictor of heart and left anterior descending artery dose in patients treated with adjuvant radiotherapy to the left breast" @default.
• W2811041349 cites W1597316589 @default.
• W2811041349 cites W1982397919 @default.
• W2811041349 cites W1987536026 @default.
• W2811041349 cites W2013091545 @default.
• W2811041349 cites W2013472456 @default.
• W2811041349 cites W2035595347 @default.
• W2811041349 cites W2046701188 @default.
• W2811041349 cites W2073662365 @default.
• W2811041349 cites W2140492419 @default.
• W2811041349 cites W2154375587 @default.
• W2811041349 cites W2158615473 @default.
• W2811041349 cites W2729000202 @default.
• W2811041349 cites W2788156346 @default.
• W2811041349 doi "https://doi.org/10.1186/s13014-018-1069-z" @default.
• W2811041349 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6032565" @default.
• W2811041349 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29973243" @default.
• W2811041349 hasPublicationYear "2018" @default.
• W2811041349 type Work @default.
• W2811041349 sameAs 2811041349 @default.
• W2811041349 citedByCount "9" @default.
• W2811041349 countsByYear W28110413492018 @default.
• W2811041349 countsByYear W28110413492019 @default.
• W2811041349 countsByYear W28110413492020 @default.
• W2811041349 countsByYear W28110413492021 @default.
• W2811041349 countsByYear W28110413492022 @default.
• W2811041349 crossrefType "journal-article" @default.
• W2811041349 hasAuthorship W2811041349A5000161940 @default.
• W2811041349 hasAuthorship W2811041349A5012945339 @default.
• W2811041349 hasAuthorship W2811041349A5016085567 @default.
• W2811041349 hasAuthorship W2811041349A5017024734 @default.
• W2811041349 hasAuthorship W2811041349A5038486476 @default.
• W2811041349 hasAuthorship W2811041349A5057188360 @default.
• W2811041349 hasAuthorship W2811041349A5060617607 @default.
• W2811041349 hasAuthorship W2811041349A5068878236 @default.
• W2811041349 hasAuthorship W2811041349A5070892204 @default.
• W2811041349 hasAuthorship W2811041349A5071660222 @default.
• W2811041349 hasAuthorship W2811041349A5083773941 @default.
• W2811041349 hasBestOaLocation W28110413491 @default.
• W2811041349 hasConcept C121608353 @default.
• W2811041349 hasConcept C125567185 @default.
• W2811041349 hasConcept C126322002 @default.
• W2811041349 hasConcept C126838900 @default.
• W2811041349 hasConcept C141071460 @default.
• W2811041349 hasConcept C160798450 @default.
• W2811041349 hasConcept C2777757722 @default.
• W2811041349 hasConcept C2781467025 @default.
• W2811041349 hasConcept C2989005 @default.
• W2811041349 hasConcept C3018454096 @default.
• W2811041349 hasConcept C509974204 @default.
• W2811041349 hasConcept C530470458 @default.
• W2811041349 hasConcept C71924100 @default.
• W2811041349 hasConcept C75088862 @default.
• W2811041349 hasConceptScore W2811041349C121608353 @default.
• W2811041349 hasConceptScore W2811041349C125567185 @default.
• W2811041349 hasConceptScore W2811041349C126322002 @default.
• W2811041349 hasConceptScore W2811041349C126838900 @default.
• W2811041349 hasConceptScore W2811041349C141071460 @default.
• W2811041349 hasConceptScore W2811041349C160798450 @default.
• W2811041349 hasConceptScore W2811041349C2777757722 @default.
• W2811041349 hasConceptScore W2811041349C2781467025 @default.
• W2811041349 hasConceptScore W2811041349C2989005 @default.
• W2811041349 hasConceptScore W2811041349C3018454096 @default.
• W2811041349 hasConceptScore W2811041349C509974204 @default.
• W2811041349 hasConceptScore W2811041349C530470458 @default.
• W2811041349 hasConceptScore W2811041349C71924100 @default.
• W2811041349 hasConceptScore W2811041349C75088862 @default.
• W2811041349 hasIssue "1" @default.
• W2811041349 hasLocation W28110413491 @default.
• W2811041349 hasLocation W28110413492 @default.
• W2811041349 hasLocation W28110413493 @default.
• W2811041349 hasLocation W28110413494 @default.
• W2811041349 hasOpenAccess W2811041349 @default.
• W2811041349 hasPrimaryLocation W28110413491 @default.
• W2811041349 hasRelatedWork W2001375849 @default.
• W2811041349 hasRelatedWork W2006183794 @default.
• W2811041349 hasRelatedWork W2017418495 @default.
• W2811041349 hasRelatedWork W2026528613 @default.
• W2811041349 hasRelatedWork W2051317037 @default.
• W2811041349 hasRelatedWork W2083281946 @default.
• W2811041349 hasRelatedWork W2106734666 @default.
• W2811041349 hasRelatedWork W2126696112 @default.
• W2811041349 hasRelatedWork W2427968717 @default.
• W2811041349 hasRelatedWork W3029766897 @default.
• W2811041349 hasVolume "13" @default.

• next