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- W2811075162 abstract "Ubiquitous expression of CD19 on B cell non-Hodgkin lymphoma identified it as a potential target for immune-based therapies.This article reviews the current literature on anti-CD19 therapies currently in clinical trials including monoclonal antibodies (mAb), antibody targeted cytotoxic drug conjugates (ADC), bispecific antibodies, and chimeric antigen receptor (CAR) modified T cells.Naked anti-CD19 mAbs have shown little clinical benefit in B cell lymphomas. Despite unusual toxicity profiles with many anti-CD19 ADCs slowing development, durable remissions in a substantial minority of patients with refractory aggressive lymphomas should encourage continued efforts in this area. Blinatumomab, an anti-CD19 bispecific T cell engager, has shown impressive responses in relapse/refractory diffuse large B cell lymphoma (DLBCL), but is plagued by neurotoxicity issues and the need for continuous infusion. CD19 targeting CAR-T cell therapies are the most promising, with the potential for curing a third of refractory DLBCL patients. There is still much work to be done to address potentially life-threatening cytokine release syndrome and neurotoxicity, an extended production time precluding patients with rapidly progressive disease, and treatment expense. However, if the promise of CAR-T cell technology is confirmed, this will likely change the approach and prognosis for relapse/refractory aggressive lymphoma." @default.
- W2811075162 created "2018-07-10" @default.
- W2811075162 creator A5005446802 @default.
- W2811075162 creator A5011189067 @default.
- W2811075162 date "2018-07-03" @default.
- W2811075162 modified "2023-10-14" @default.
- W2811075162 title "CD19-targeted immunotherapies for treatment of patients with non-Hodgkin B-cell lymphomas" @default.
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- W2811075162 doi "https://doi.org/10.1080/13543784.2018.1492549" @default.
- W2811075162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29940805" @default.
- W2811075162 hasPublicationYear "2018" @default.
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