Matches in SemOpenAlex for { <https://semopenalex.org/work/W2811103652> ?p ?o ?g. }
- W2811103652 endingPage "3826" @default.
- W2811103652 startingPage "3817" @default.
- W2811103652 abstract "Tumor-associated macrophage-derived cytokines enhance cancer stem-like characteristics through epithelial-mesenchymal transition Yongxu Chen,1,2,* Wei Tan,1 Changjun Wang1,2,* 1Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute, Guangzhou, Guangdong Province, People’s Republic of China; 2School of Medicine, South China University of Technology, Guangzhou, Guangdong Province, People’s Republic of China *All authors contributed equally to this work Abstract: Cancer stem cells are a small population of cells with the potential for self-renewal and multi-directional differentiation and are an important source of cancer initiation, treatment resistance, and recurrence. Epithelial–mesenchymal transition (EMT) is a process in which epithelial cells lose their epithelial phenotype and convert to mesenchymal cells. Recent studies have shown that cancer cells undergoing EMT can become stem-like cells. Many kinds of tumors are associated with chronic inflammation, which plays a role in tumor progression. Among the various immune cells mediating chronic inflammation, macrophages account for ~30%–50% of the tumor mass. Macrophages are highly infiltrative in the tumor microenvironment and secrete a series of inflammatory factors and cytokines, such as transforming growth factor (TGF)-β, IL-6, IL-10, and tumor necrosis factor (TNF)-α, which promote EMT and enhance the stemness of cancer cells. This review summarizes and discusses recent research findings on some specific mechanisms of tumor-associated macrophage-derived cytokines in EMT and cancer stemness transition, which are emerging targets of cancer treatment. Keywords: macrophage, cancer stem cell, tumor immunology, inflammatory cytokine, tumor microenvironment" @default.
- W2811103652 created "2018-07-10" @default.
- W2811103652 creator A5033174535 @default.
- W2811103652 creator A5054279717 @default.
- W2811103652 creator A5077284054 @default.
- W2811103652 date "2018-07-01" @default.
- W2811103652 modified "2023-10-17" @default.
- W2811103652 title "Tumor-associated macrophage-derived cytokines enhance cancer stem-like characteristics through epithelial–mesenchymal transition" @default.
- W2811103652 cites W1498201286 @default.
- W2811103652 cites W1534965343 @default.
- W2811103652 cites W1572664742 @default.
- W2811103652 cites W1587752510 @default.
- W2811103652 cites W1758075256 @default.
- W2811103652 cites W1771551064 @default.
- W2811103652 cites W1934903822 @default.
- W2811103652 cites W1963501822 @default.
- W2811103652 cites W1963717723 @default.
- W2811103652 cites W1969057487 @default.
- W2811103652 cites W1970433764 @default.
- W2811103652 cites W1978878974 @default.
- W2811103652 cites W1987907341 @default.
- W2811103652 cites W1988799190 @default.
- W2811103652 cites W1992551577 @default.
- W2811103652 cites W1995791298 @default.
- W2811103652 cites W2000799034 @default.
- W2811103652 cites W2003329558 @default.
- W2811103652 cites W2003547729 @default.
- W2811103652 cites W2010417415 @default.
- W2811103652 cites W2017056838 @default.
- W2811103652 cites W2017067863 @default.
- W2811103652 cites W2018924468 @default.
- W2811103652 cites W2019764524 @default.
- W2811103652 cites W2021038702 @default.
- W2811103652 cites W2023243872 @default.
- W2811103652 cites W2029440596 @default.
- W2811103652 cites W2030035194 @default.
- W2811103652 cites W2037535775 @default.
- W2811103652 cites W2041360481 @default.
- W2811103652 cites W2043140203 @default.
- W2811103652 cites W2046932904 @default.
- W2811103652 cites W2054066093 @default.
- W2811103652 cites W2054928391 @default.
- W2811103652 cites W2055703363 @default.
- W2811103652 cites W2075670261 @default.
- W2811103652 cites W2079347162 @default.
- W2811103652 cites W2081174442 @default.
- W2811103652 cites W2092051360 @default.
- W2811103652 cites W2092630587 @default.
- W2811103652 cites W2096670610 @default.
- W2811103652 cites W2097983026 @default.
- W2811103652 cites W2113207478 @default.
- W2811103652 cites W2119145947 @default.
- W2811103652 cites W2124156632 @default.
- W2811103652 cites W2132265884 @default.
- W2811103652 cites W2135068751 @default.
- W2811103652 cites W2138617314 @default.
- W2811103652 cites W2139103645 @default.
- W2811103652 cites W2141368303 @default.
- W2811103652 cites W2142530756 @default.
- W2811103652 cites W2144120657 @default.
- W2811103652 cites W2146679006 @default.
- W2811103652 cites W2151170616 @default.
- W2811103652 cites W2153161557 @default.
- W2811103652 cites W2158945113 @default.
- W2811103652 cites W2161074777 @default.
- W2811103652 cites W2162173979 @default.
- W2811103652 cites W2164664027 @default.
- W2811103652 cites W2175142598 @default.
- W2811103652 cites W2203717837 @default.
- W2811103652 cites W2216262028 @default.
- W2811103652 cites W2227211170 @default.
- W2811103652 cites W2230498513 @default.
- W2811103652 cites W2265549878 @default.
- W2811103652 cites W2269768516 @default.
- W2811103652 cites W2314057593 @default.
- W2811103652 cites W2317030863 @default.
- W2811103652 cites W2321316280 @default.
- W2811103652 cites W2324080174 @default.
- W2811103652 cites W2327125795 @default.
- W2811103652 cites W2343558773 @default.
- W2811103652 cites W2344409258 @default.
- W2811103652 cites W2346656439 @default.
- W2811103652 cites W2408222419 @default.
- W2811103652 cites W2416252233 @default.
- W2811103652 cites W2464201655 @default.
- W2811103652 cites W2485073741 @default.
- W2811103652 cites W2499794199 @default.
- W2811103652 cites W2515730340 @default.
- W2811103652 cites W2519490965 @default.
- W2811103652 cites W2526447978 @default.
- W2811103652 cites W2526505865 @default.
- W2811103652 cites W2527930826 @default.
- W2811103652 cites W2528083170 @default.
- W2811103652 cites W2546597833 @default.
- W2811103652 cites W254784451 @default.
- W2811103652 cites W2563782583 @default.
- W2811103652 cites W2573642381 @default.
- W2811103652 cites W2575156365 @default.