FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2811104177> ?p ?o ?g. }

• W2811104177 endingPage "259" @default.
• W2811104177 startingPage "249" @default.
• W2811104177 abstract "Cancer cell targeted therapy using a biocompatible targeted drug delivery system can increase the therapeutic effects of cellular cancer therapy. Here, we report a Folic Acid (FA) and polyethyleneimine (PEI) functionalized Graphene Oxide (GO) nanocarrier, FA-PEI-GO, used to deliver two new Copper complexes into the folate-receptor-positive nasopharyngeal carcinoma cell line. GO was prepared by modified Hummers method and then decorated by PEI and FA. Afterwards, the material was characterized by the X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and atomic force microscopy (AFM). Copper complexes were synthesized by a hydrothermal method and then characterized by single crystal X-ray diffraction analysis. Cytotoxicity assessment of the complexes illustrated that the IC50 values against the nasopharyngeal carcinoma cell lines, HNE-1 and CNE-2, were, respectively, 17.7 ± 1.2, 13.2 ± 1.9, 6.7 ± 0.8, 2.9 ± 0.7 μM. Flow cytometry findings suggested that both complexes were capable of decreasing cancer cell viability through causing late-stage cell apoptosis. The obtained targeted drug delivery systems had good biocompatibility and stability. Compared with Cis-Dichlorodiamineplatinum (CDDP), the non-specific antitumor drug normally used in chemotherapy, one of the obtained agents had similar therapeutic effect while the other had significantly higher activity, suggesting future possible application of this new targeted therapy against nasopharyngeal carcinoma." @default.
• W2811104177 created "2018-07-10" @default.
• W2811104177 creator A5037783744 @default.
• W2811104177 creator A5042200052 @default.
• W2811104177 creator A5066349538 @default.
• W2811104177 creator A5069820275 @default.
• W2811104177 creator A5074037652 @default.
• W2811104177 date "2018-10-01" @default.
• W2811104177 modified "2023-09-28" @default.
• W2811104177 title "Functionalized Graphene Oxide as a nanocarrier of new Copper (II) complexes for targeted therapy on nasopharyngeal carcinoma" @default.
• W2811104177 cites W1500209468 @default.
• W2811104177 cites W1967432304 @default.
• W2811104177 cites W1969900346 @default.
• W2811104177 cites W1976787731 @default.
• W2811104177 cites W1980419364 @default.
• W2811104177 cites W1985691093 @default.
• W2811104177 cites W1991605413 @default.
• W2811104177 cites W2001119796 @default.
• W2811104177 cites W2031016295 @default.
• W2811104177 cites W2032760352 @default.
• W2811104177 cites W2047649847 @default.
• W2811104177 cites W2050874478 @default.
• W2811104177 cites W2059179694 @default.
• W2811104177 cites W2160656343 @default.
• W2811104177 cites W2164277862 @default.
• W2811104177 cites W2526747727 @default.
• W2811104177 cites W2579293753 @default.
• W2811104177 cites W2773120666 @default.
• W2811104177 cites W2789376898 @default.
• W2811104177 cites W2797185390 @default.
• W2811104177 cites W2804618800 @default.
• W2811104177 cites W4210983491 @default.
• W2811104177 cites W4233194460 @default.
• W2811104177 doi "https://doi.org/10.1016/j.ejps.2018.07.006" @default.
• W2811104177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29981404" @default.
• W2811104177 hasPublicationYear "2018" @default.
• W2811104177 type Work @default.
• W2811104177 sameAs 2811104177 @default.
• W2811104177 citedByCount "18" @default.
• W2811104177 countsByYear W28111041772018 @default.
• W2811104177 countsByYear W28111041772019 @default.
• W2811104177 countsByYear W28111041772020 @default.
• W2811104177 countsByYear W28111041772021 @default.
• W2811104177 countsByYear W28111041772022 @default.
• W2811104177 countsByYear W28111041772023 @default.
• W2811104177 crossrefType "journal-article" @default.
• W2811104177 hasAuthorship W2811104177A5037783744 @default.
• W2811104177 hasAuthorship W2811104177A5042200052 @default.
• W2811104177 hasAuthorship W2811104177A5066349538 @default.
• W2811104177 hasAuthorship W2811104177A5069820275 @default.
• W2811104177 hasAuthorship W2811104177A5074037652 @default.
• W2811104177 hasConcept C109316439 @default.
• W2811104177 hasConcept C121608353 @default.
• W2811104177 hasConcept C126322002 @default.
• W2811104177 hasConcept C127413603 @default.
• W2811104177 hasConcept C13965031 @default.
• W2811104177 hasConcept C171250308 @default.
• W2811104177 hasConcept C175708663 @default.
• W2811104177 hasConcept C178790620 @default.
• W2811104177 hasConcept C18150654 @default.
• W2811104177 hasConcept C185592680 @default.
• W2811104177 hasConcept C192562407 @default.
• W2811104177 hasConcept C202751555 @default.
• W2811104177 hasConcept C2777230088 @default.
• W2811104177 hasConcept C2778997737 @default.
• W2811104177 hasConcept C2779820397 @default.
• W2811104177 hasConcept C2781230642 @default.
• W2811104177 hasConcept C30080830 @default.
• W2811104177 hasConcept C42360764 @default.
• W2811104177 hasConcept C502942594 @default.
• W2811104177 hasConcept C509974204 @default.
• W2811104177 hasConcept C55493867 @default.
• W2811104177 hasConcept C71924100 @default.
• W2811104177 hasConceptScore W2811104177C109316439 @default.
• W2811104177 hasConceptScore W2811104177C121608353 @default.
• W2811104177 hasConceptScore W2811104177C126322002 @default.
• W2811104177 hasConceptScore W2811104177C127413603 @default.
• W2811104177 hasConceptScore W2811104177C13965031 @default.
• W2811104177 hasConceptScore W2811104177C171250308 @default.
• W2811104177 hasConceptScore W2811104177C175708663 @default.
• W2811104177 hasConceptScore W2811104177C178790620 @default.
• W2811104177 hasConceptScore W2811104177C18150654 @default.
• W2811104177 hasConceptScore W2811104177C185592680 @default.
• W2811104177 hasConceptScore W2811104177C192562407 @default.
• W2811104177 hasConceptScore W2811104177C202751555 @default.
• W2811104177 hasConceptScore W2811104177C2777230088 @default.
• W2811104177 hasConceptScore W2811104177C2778997737 @default.
• W2811104177 hasConceptScore W2811104177C2779820397 @default.
• W2811104177 hasConceptScore W2811104177C2781230642 @default.
• W2811104177 hasConceptScore W2811104177C30080830 @default.
• W2811104177 hasConceptScore W2811104177C42360764 @default.
• W2811104177 hasConceptScore W2811104177C502942594 @default.
• W2811104177 hasConceptScore W2811104177C509974204 @default.
• W2811104177 hasConceptScore W2811104177C55493867 @default.
• W2811104177 hasConceptScore W2811104177C71924100 @default.
• W2811104177 hasFunder F4320335907 @default.
• W2811104177 hasLocation W28111041771 @default.
• W2811104177 hasLocation W28111041772 @default.

• next