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- W2811105296 abstract "As collective cell migration is intimately involved in different aspects of metazoan development, molecular mechanisms underlying this process are being explored in a variety of developmental contexts. Border cell (BC) migration during Drosophila oogenesis has emerged as an excellent genetic model for studying collective cell migration. BCs are of epithelial origin but acquire partial mesenchymal characteristics before migrating as a group towards the oocyte. Here we report that insulin signalling modulates collective BC movement during Drosophila oogenesis. Supporting the involvement of Insulin pathway, we demonstrate that compromising Insulin-like Receptor (dInR) levels in BCs, inhibits their migration. Furthermore, we show that canonical Insulin signalling pathway components participate in this process. Interestingly, visualization of dInR-depleted BC clusters, using time-lapse imaging, revealed a delay in detachment of BC clusters from the surrounding anterior follicle cells and altered protrusion dynamics. Lastly, based on genetic interactions between dInR, the polarity determinant, dPAR-1 and a regulatory subunit of Drosophila Myosin, (Spaghetti squash) we propose that Insulin signalling likely influences dPAR-1 activity to engineer border cell detachment and subsequent movement via Drosophila Myosin." @default.
- W2811105296 created "2018-07-10" @default.
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- W2811105296 date "2018-01-01" @default.
- W2811105296 modified "2023-09-23" @default.
- W2811105296 title "Insulin signaling modulates border cell movement in <i>Drosophila</i> oogenesis" @default.
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- W2811105296 doi "https://doi.org/10.1242/dev.166165" @default.
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