FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2811116997> ?p ?o ?g. }

• W2811116997 abstract "Abstract OTUB1 is a deubiquitinating enzyme that cleaves K48-linked polyubiquitin chains and also regulates ubiquitin signaling through a unique, non-catalytic mechanism. OTUB1 binds to a subset of E2 ubiquitin conjugating enzymes and inhibits their activity by trapping the E2~ubiquitin thioester and preventing ubiquitin transfer. The same set of E2s stimulate the deubiquitinating activity of OTUB1 when the E2 is not charged with ubiquitin. Previous studies have shown that, in cells, OTUB1 binds to members of the UBE2D (UBCH5) and UBE2E families, as well as to UBC13 (UBE2N). Cellular roles have been identified for the interaction of OTUB1 with UBC13 and members of the UBE2D family, but not for UBE2E E2 enzymes. We report here a novel role for OTUB1-E2 interactions in modulating E2 protein ubiquitination. We find that depletion of OTUB1 dramatically destabilizes the E2 conjugating enzyme UBE2E1 (UBE2E1) in cells and that this effect is independent of the catalytic activity of OTUB1 but depends on the ability of OTUB1 to bind to UBE2E1. We show that OTUB1 suppresses UBE2E1 autoubiquitination in vitro and in cells, thereby preventing UBE2E1 from being targeted to the proteasome for degradation. Taken together, we have found a new role for OTUB1 in rescuing specific E2s from degradation in vivo ." @default.
• W2811116997 created "2018-07-10" @default.
• W2811116997 creator A5021865796 @default.
• W2811116997 creator A5046099334 @default.
• W2811116997 creator A5048250130 @default.
• W2811116997 creator A5060002881 @default.
• W2811116997 creator A5061257516 @default.
• W2811116997 creator A5089331697 @default.
• W2811116997 date "2018-06-29" @default.
• W2811116997 modified "2023-09-23" @default.
• W2811116997 title "OTUB1 non-catalytically regulates the stability of the E2 ubiquitin conjugating enzyme UBE2E1" @default.
• W2811116997 cites W1564987250 @default.
• W2811116997 cites W1576842236 @default.
• W2811116997 cites W1603781996 @default.
• W2811116997 cites W1611787727 @default.
• W2811116997 cites W1775389407 @default.
• W2811116997 cites W1966429292 @default.
• W2811116997 cites W1971128251 @default.
• W2811116997 cites W1977058089 @default.
• W2811116997 cites W1977709885 @default.
• W2811116997 cites W1978139429 @default.
• W2811116997 cites W1978859439 @default.
• W2811116997 cites W1986429623 @default.
• W2811116997 cites W1989474213 @default.
• W2811116997 cites W1999290683 @default.
• W2811116997 cites W2001499126 @default.
• W2811116997 cites W2008689421 @default.
• W2811116997 cites W2021565943 @default.
• W2811116997 cites W2022690300 @default.
• W2811116997 cites W2034187114 @default.
• W2811116997 cites W2034346780 @default.
• W2811116997 cites W2037407781 @default.
• W2811116997 cites W2040930425 @default.
• W2811116997 cites W2045174330 @default.
• W2811116997 cites W2045435533 @default.
• W2811116997 cites W2045979076 @default.
• W2811116997 cites W2047161080 @default.
• W2811116997 cites W2047823765 @default.
• W2811116997 cites W2048280438 @default.
• W2811116997 cites W2060870400 @default.
• W2811116997 cites W2062137294 @default.
• W2811116997 cites W2075939050 @default.
• W2811116997 cites W2106969933 @default.
• W2811116997 cites W2118225942 @default.
• W2811116997 cites W2128579113 @default.
• W2811116997 cites W2133819225 @default.
• W2811116997 cites W2135700703 @default.
• W2811116997 cites W2146497742 @default.
• W2811116997 cites W2147917253 @default.
• W2811116997 cites W2150925238 @default.
• W2811116997 cites W2152680939 @default.
• W2811116997 cites W2281556458 @default.
• W2811116997 cites W2405470874 @default.
• W2811116997 cites W2409179396 @default.
• W2811116997 cites W243680554 @default.
• W2811116997 cites W2565996772 @default.
• W2811116997 cites W2570733907 @default.
• W2811116997 cites W2755866416 @default.
• W2811116997 cites W2786303119 @default.
• W2811116997 doi "https://doi.org/10.1101/359414" @default.
• W2811116997 hasPublicationYear "2018" @default.
• W2811116997 type Work @default.
• W2811116997 sameAs 2811116997 @default.
• W2811116997 citedByCount "0" @default.
• W2811116997 crossrefType "posted-content" @default.
• W2811116997 hasAuthorship W2811116997A5021865796 @default.
• W2811116997 hasAuthorship W2811116997A5046099334 @default.
• W2811116997 hasAuthorship W2811116997A5048250130 @default.
• W2811116997 hasAuthorship W2811116997A5060002881 @default.
• W2811116997 hasAuthorship W2811116997A5061257516 @default.
• W2811116997 hasAuthorship W2811116997A5089331697 @default.
• W2811116997 hasBestOaLocation W28111169971 @default.
• W2811116997 hasConcept C102658986 @default.
• W2811116997 hasConcept C104317684 @default.
• W2811116997 hasConcept C134459356 @default.
• W2811116997 hasConcept C181199279 @default.
• W2811116997 hasConcept C182561583 @default.
• W2811116997 hasConcept C185592680 @default.
• W2811116997 hasConcept C202751555 @default.
• W2811116997 hasConcept C25602115 @default.
• W2811116997 hasConcept C27740335 @default.
• W2811116997 hasConcept C2778834346 @default.
• W2811116997 hasConcept C55493867 @default.
• W2811116997 hasConcept C86803240 @default.
• W2811116997 hasConcept C95444343 @default.
• W2811116997 hasConceptScore W2811116997C102658986 @default.
• W2811116997 hasConceptScore W2811116997C104317684 @default.
• W2811116997 hasConceptScore W2811116997C134459356 @default.
• W2811116997 hasConceptScore W2811116997C181199279 @default.
• W2811116997 hasConceptScore W2811116997C182561583 @default.
• W2811116997 hasConceptScore W2811116997C185592680 @default.
• W2811116997 hasConceptScore W2811116997C202751555 @default.
• W2811116997 hasConceptScore W2811116997C25602115 @default.
• W2811116997 hasConceptScore W2811116997C27740335 @default.
• W2811116997 hasConceptScore W2811116997C2778834346 @default.
• W2811116997 hasConceptScore W2811116997C55493867 @default.
• W2811116997 hasConceptScore W2811116997C86803240 @default.
• W2811116997 hasConceptScore W2811116997C95444343 @default.
• W2811116997 hasLocation W28111169971 @default.
• W2811116997 hasLocation W28111169972 @default.

• next