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- W2811156674 endingPage "810.e3" @default.
- W2811156674 startingPage "805" @default.
- W2811156674 abstract "Abstract Deceased donation of kidneys for transplantation may occur through either brain death (BD) or donation after circulatory death (DCD) pathways with similar long-term benefit. Absolute contraindications to donation are few, and donors with chronic comorbidities such as hypertension and vascular disease frequently are considered. BD and its associated pathophysiology can affect graft function, necessitating careful supportive treatment in the intensive care unit (ICU), paying attention to the cardiovascular, endocrine, respiratory, and hematologic changes. Although maintenance of physiologic homeostasis appears logical, there is insufficient evidence to support a particular management algorithm over another. Nonetheless, hormonal supplementation frequently is used based on retrospective data showing increased graft use from donors treated with these agents in combination. DCD may be “controlled” (after withdrawal of ICU supports in anticipation of death), or “uncontrolled” (donation after a failed resuscitation attempt). In controlled DCD the principles of physiologic support and management before death are similar to other ICU patients, recognizing the specific ethical and legal considerations relating to antemortem interventions in these patients. In uncontrolled DCD the focus is on postmortem interventions, such as regional normothermic or hypothermic perfusion. Machine cold perfusion and ex vivo normothermic perfusion are additional strategies that are being evaluated to assess and preserve graft function in DCD donors." @default.
- W2811156674 created "2018-07-10" @default.
- W2811156674 creator A5027519999 @default.
- W2811156674 creator A5054756704 @default.
- W2811156674 date "2019-01-01" @default.
- W2811156674 modified "2023-09-26" @default.
- W2811156674 title "Renal Protection in the Organ Donor" @default.
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