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- W2811156719 endingPage "533" @default.
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- W2811156719 abstract "The circadian clock plays a critical role in regulating the immune system. Our previous publication revealed that a mutation in the circadian gene period1b (per1b) in zebrafish significantly decreased proinflammatory gene expression, particularly under constant darkness (DD) conditions; however, the underlying mechanisms remain unclear. In this study, using per1b-null mutant zebrafish and a larval tail fin injury model, we observed that the loss of per1b resulted in the downregulation expression of proinflammatory cytokines, such as IL-6 and TNF-α, at protein level. Furthermore, the loss of per1b downregulated ERK phosphorylation and inhibited p65 phosphorylation, leading to reduced NF-κB activation, which could downregulate the expression of proinflammatory cytokines, such as IL-6 and TNF-α, in zebrafish. These results provided insight into the communication between the circadian clock and immune functions." @default.
- W2811156719 created "2018-07-10" @default.
- W2811156719 creator A5053317409 @default.
- W2811156719 creator A5057292712 @default.
- W2811156719 creator A5076787351 @default.
- W2811156719 date "2018-09-01" @default.
- W2811156719 modified "2023-10-05" @default.
- W2811156719 title "Circadian gene period1b regulates proinflammatory cytokine expression through NF–κB signalling in zebrafish" @default.
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- W2811156719 doi "https://doi.org/10.1016/j.fsi.2018.06.040" @default.
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