FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2811156921> ?p ?o ?g. }

• W2811156921 endingPage "184" @default.
• W2811156921 startingPage "176" @default.
• W2811156921 abstract "The prevalence of inflammatory bowel diseases is uprising in countries like Iran. Genetic predisposing elements play prominent role in the pathogenesis of Crohn's disease. In this study we studied the role of autophagy genes like IRGM (Immunity related GTPase M) and ATG16L1 (Autophagy related 16 like 1) in the pathogenesis of Crohn's Disease in Iranian patients.One hundred thirty-eight patients and 99 normal controls were recruited in this study. Polymorphisms in -1644 and -308 upstream of IRGM gene were studied by PCR-sequencing and 20 kb CNVdel/insertion was studied by specific PCR. Rs10065171, rs4958847 in IRGM gene and rs2241880 in ATG16L1 were studied by Taqman genotyping assays.None of the so-called predisposing alleles of IRGM gene predispose Iranians to Crohn's disease while the prevalence of some of them like CNV deletion was higher in normal controls. Surprisingly all the so-called predisposing alleles in IRGM were linked to each other (especially rs4958847 with rs10065172 and polymorphisms in -308 region with rs4958847). Patients harboring A allele in rs4958847 site showed higher ratio of fibrostenotic type of disease while in patients with C/T genotype in rs4958847, colonic involvement was seen more frequently. G allele in ATG16L1 was associated with Crohn's disease though it was not associated with any phenotypic manifestation.In our study the association of ATG16L1 to Crohn's disease in Iranian patients was confirmed while it was shown that the studied polymorphisms in IRGM was not associated with Crohn's disease. Therefore in order to have a better picture about the genetics of Crohn's disease in Iranian patients, it is recommended to study other clinically effective polymorphisms in IRGM and ATG16L1 in addition to other genes which are responsible for the process of autophagy." @default.
• W2811156921 created "2018-07-10" @default.
• W2811156921 creator A5017121246 @default.
• W2811156921 creator A5038516179 @default.
• W2811156921 creator A5041182198 @default.
• W2811156921 creator A5055158419 @default.
• W2811156921 creator A5075037888 @default.
• W2811156921 date "2018-10-01" @default.
• W2811156921 modified "2023-10-18" @default.
• W2811156921 title "Among autophagy genes, ATG16L1 but not IRGM is associated with Crohn's disease in Iranians" @default.
• W2811156921 cites W126867851 @default.
• W2811156921 cites W1588546052 @default.
• W2811156921 cites W1967365974 @default.
• W2811156921 cites W1969892059 @default.
• W2811156921 cites W1978890834 @default.
• W2811156921 cites W1981411352 @default.
• W2811156921 cites W1993563063 @default.
• W2811156921 cites W1997792430 @default.
• W2811156921 cites W1999088461 @default.
• W2811156921 cites W2000562622 @default.
• W2811156921 cites W2001303987 @default.
• W2811156921 cites W2003031817 @default.
• W2811156921 cites W2006868978 @default.
• W2811156921 cites W2009144078 @default.
• W2811156921 cites W2009258758 @default.
• W2811156921 cites W2011197968 @default.
• W2811156921 cites W2016138147 @default.
• W2811156921 cites W2027560883 @default.
• W2811156921 cites W2046882952 @default.
• W2811156921 cites W2055292040 @default.
• W2811156921 cites W2065315761 @default.
• W2811156921 cites W2065637841 @default.
• W2811156921 cites W2066203385 @default.
• W2811156921 cites W2084708009 @default.
• W2811156921 cites W2093356677 @default.
• W2811156921 cites W2100443415 @default.
• W2811156921 cites W2114905980 @default.
• W2811156921 cites W2114938079 @default.
• W2811156921 cites W2122031852 @default.
• W2811156921 cites W2126769079 @default.
• W2811156921 cites W2134898472 @default.
• W2811156921 cites W2140541163 @default.
• W2811156921 cites W2143625465 @default.
• W2811156921 cites W2147221190 @default.
• W2811156921 cites W2153386060 @default.
• W2811156921 cites W2165279431 @default.
• W2811156921 cites W2170275918 @default.
• W2811156921 cites W2188248802 @default.
• W2811156921 cites W2315269263 @default.
• W2811156921 cites W2325676680 @default.
• W2811156921 cites W2424543811 @default.
• W2811156921 doi "https://doi.org/10.1016/j.gene.2018.06.074" @default.
• W2811156921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29960072" @default.
• W2811156921 hasPublicationYear "2018" @default.
• W2811156921 type Work @default.
• W2811156921 sameAs 2811156921 @default.
• W2811156921 citedByCount "5" @default.
• W2811156921 countsByYear W28111569212019 @default.
• W2811156921 countsByYear W28111569212020 @default.
• W2811156921 countsByYear W28111569212022 @default.
• W2811156921 crossrefType "journal-article" @default.
• W2811156921 hasAuthorship W2811156921A5017121246 @default.
• W2811156921 hasAuthorship W2811156921A5038516179 @default.
• W2811156921 hasAuthorship W2811156921A5041182198 @default.
• W2811156921 hasAuthorship W2811156921A5055158419 @default.
• W2811156921 hasAuthorship W2811156921A5075037888 @default.
• W2811156921 hasConcept C104317684 @default.
• W2811156921 hasConcept C126322002 @default.
• W2811156921 hasConcept C135763542 @default.
• W2811156921 hasConcept C180754005 @default.
• W2811156921 hasConcept C187092789 @default.
• W2811156921 hasConcept C203014093 @default.
• W2811156921 hasConcept C2778260677 @default.
• W2811156921 hasConcept C2779134260 @default.
• W2811156921 hasConcept C2779280984 @default.
• W2811156921 hasConcept C2780942790 @default.
• W2811156921 hasConcept C31467283 @default.
• W2811156921 hasConcept C54355233 @default.
• W2811156921 hasConcept C71924100 @default.
• W2811156921 hasConcept C86803240 @default.
• W2811156921 hasConceptScore W2811156921C104317684 @default.
• W2811156921 hasConceptScore W2811156921C126322002 @default.
• W2811156921 hasConceptScore W2811156921C135763542 @default.
• W2811156921 hasConceptScore W2811156921C180754005 @default.
• W2811156921 hasConceptScore W2811156921C187092789 @default.
• W2811156921 hasConceptScore W2811156921C203014093 @default.
• W2811156921 hasConceptScore W2811156921C2778260677 @default.
• W2811156921 hasConceptScore W2811156921C2779134260 @default.
• W2811156921 hasConceptScore W2811156921C2779280984 @default.
• W2811156921 hasConceptScore W2811156921C2780942790 @default.
• W2811156921 hasConceptScore W2811156921C31467283 @default.
• W2811156921 hasConceptScore W2811156921C54355233 @default.
• W2811156921 hasConceptScore W2811156921C71924100 @default.
• W2811156921 hasConceptScore W2811156921C86803240 @default.
• W2811156921 hasFunder F4320322670 @default.
• W2811156921 hasFunder F4320326567 @default.
• W2811156921 hasLocation W28111569211 @default.
• W2811156921 hasLocation W28111569212 @default.

• next