Matches in SemOpenAlex for { <https://semopenalex.org/work/W2811157090> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2811157090 abstract "Obese patients have higher levels of free fatty acids (FFAs) in their plasma and a higher risk of cancer than their non-obese counterparts. However, the mechanisms involved in the regulation of cancer metastasis by FFAs remain unclear. In this study, we found that oleic acid (OA) induced angiopoietin-like 4 (ANGPTL4) protein expression and secretion and conferred anoikis resistance to head and neck squamous cell carcinomas (HNSCCs). The autocrine production of OA-induced ANGPTL4 further promoted HNSCC migration and invasion. In addition, the expression of peroxisome proliferator-activated receptor (PPAR) was essential for the OA-induced ANGPTL4 expression and invasion. The levels of OA-induced epithelial-mesenchymal transition markers, such as vimentin, MMP-9, and fibronectin and its downstream effectors Rac1/Cdc42, were significantly reduced in ANGPTL4-depleted cells. Knocking down fibronectin not only inhibited the expression of MMP-9 but also repressed OA- and recombinant ANGPTL4-induced HNSCC invasion. On the other hand, ANGPTL4 siRNA inhibited OA-induced MMP-9 expression, which was reversed in fibronectin-overexpressing cells. Furthermore, the depletion of ANGPTL4 impeded the OA-primed metastatic seeding of tumor cells in the lungs. These results demonstrate that OA enhances HNSCC metastasis through the ANGPTL4/fibronectin/Rac1/Cdc42 and ANGPTL4/fibronectin/MMP-9 signaling axes. The inhibition of ANGPTL4 could be a potential strategy for the treatment of FFA-mediated HNSCC metastasis. Citation Format: Chih-Jie Shen, Shih-Hung Chan, Chung-Ta Lee, Wan-Chen Huang, Jhih-Peng Tsai, Kwang-Yu Chang, Wen-Chang Chang, Ben-Kuen Chen. Oleic acid promotes head and neck squamous cell carcinoma anoikis resistance and metastasis via ANGPTL4/fibronectin pathway [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 85." @default.
- W2811157090 created "2018-07-10" @default.
- W2811157090 creator A5010597155 @default.
- W2811157090 creator A5011909185 @default.
- W2811157090 creator A5020273179 @default.
- W2811157090 creator A5036609030 @default.
- W2811157090 creator A5040136914 @default.
- W2811157090 creator A5061266029 @default.
- W2811157090 creator A5063581616 @default.
- W2811157090 creator A5080344577 @default.
- W2811157090 date "2018-07-01" @default.
- W2811157090 modified "2023-09-26" @default.
- W2811157090 title "Abstract 85: Oleic acid promotes head and neck squamous cell carcinoma anoikis resistance and metastasis via ANGPTL4/fibronectin pathway" @default.
- W2811157090 doi "https://doi.org/10.1158/1538-7445.am2018-85" @default.
- W2811157090 hasPublicationYear "2018" @default.
- W2811157090 type Work @default.
- W2811157090 sameAs 2811157090 @default.
- W2811157090 citedByCount "0" @default.
- W2811157090 crossrefType "proceedings-article" @default.
- W2811157090 hasAuthorship W2811157090A5010597155 @default.
- W2811157090 hasAuthorship W2811157090A5011909185 @default.
- W2811157090 hasAuthorship W2811157090A5020273179 @default.
- W2811157090 hasAuthorship W2811157090A5036609030 @default.
- W2811157090 hasAuthorship W2811157090A5040136914 @default.
- W2811157090 hasAuthorship W2811157090A5061266029 @default.
- W2811157090 hasAuthorship W2811157090A5063581616 @default.
- W2811157090 hasAuthorship W2811157090A5080344577 @default.
- W2811157090 hasBestOaLocation W28111570901 @default.
- W2811157090 hasConcept C104317684 @default.
- W2811157090 hasConcept C121608353 @default.
- W2811157090 hasConcept C126322002 @default.
- W2811157090 hasConcept C1491633281 @default.
- W2811157090 hasConcept C152000582 @default.
- W2811157090 hasConcept C185592680 @default.
- W2811157090 hasConcept C2776530083 @default.
- W2811157090 hasConcept C2776833033 @default.
- W2811157090 hasConcept C2777093181 @default.
- W2811157090 hasConcept C2779013556 @default.
- W2811157090 hasConcept C502942594 @default.
- W2811157090 hasConcept C55493867 @default.
- W2811157090 hasConcept C62478195 @default.
- W2811157090 hasConcept C71924100 @default.
- W2811157090 hasConcept C77305985 @default.
- W2811157090 hasConcept C86492073 @default.
- W2811157090 hasConceptScore W2811157090C104317684 @default.
- W2811157090 hasConceptScore W2811157090C121608353 @default.
- W2811157090 hasConceptScore W2811157090C126322002 @default.
- W2811157090 hasConceptScore W2811157090C1491633281 @default.
- W2811157090 hasConceptScore W2811157090C152000582 @default.
- W2811157090 hasConceptScore W2811157090C185592680 @default.
- W2811157090 hasConceptScore W2811157090C2776530083 @default.
- W2811157090 hasConceptScore W2811157090C2776833033 @default.
- W2811157090 hasConceptScore W2811157090C2777093181 @default.
- W2811157090 hasConceptScore W2811157090C2779013556 @default.
- W2811157090 hasConceptScore W2811157090C502942594 @default.
- W2811157090 hasConceptScore W2811157090C55493867 @default.
- W2811157090 hasConceptScore W2811157090C62478195 @default.
- W2811157090 hasConceptScore W2811157090C71924100 @default.
- W2811157090 hasConceptScore W2811157090C77305985 @default.
- W2811157090 hasConceptScore W2811157090C86492073 @default.
- W2811157090 hasLocation W28111570901 @default.
- W2811157090 hasOpenAccess W2811157090 @default.
- W2811157090 hasPrimaryLocation W28111570901 @default.
- W2811157090 hasRelatedWork W1597336749 @default.
- W2811157090 hasRelatedWork W2040863351 @default.
- W2811157090 hasRelatedWork W2119783541 @default.
- W2811157090 hasRelatedWork W2493937404 @default.
- W2811157090 hasRelatedWork W2545778278 @default.
- W2811157090 hasRelatedWork W2739669430 @default.
- W2811157090 hasRelatedWork W2811157090 @default.
- W2811157090 hasRelatedWork W3000945797 @default.
- W2811157090 hasRelatedWork W3022502481 @default.
- W2811157090 hasRelatedWork W3200489044 @default.
- W2811157090 isParatext "false" @default.
- W2811157090 isRetracted "false" @default.
- W2811157090 magId "2811157090" @default.
- W2811157090 workType "article" @default.