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- W2811163292 abstract "Nitrated oleic acid (NO2-OA) was first identified in 2003, and after the characterization of its formation and thiol reactivity, it was used as a prototypical molecule to investigate the physiological actions of endogenous nitrated fatty acids (NO2-FA). Based on in vitro observations showing significant activation of cytoprotective and anti-inflammatory signaling responses by NO2-FA, experiments were designed to determine their pharmacological potential. Supported by strong intellectual protection and favorable pharmacokinetic and pharmacodynamic data, 10-NO2-OA (CXA-10) underwent pharmaceutical development as a drug to treat fibrotic and inflammatory diseases. NO2-FA are at the intersection of three unconventional drug candidate classes that include 1) fatty acids, 2) metabolic intermediates and 3) electrophilic molecules. These three groups use different scaffolds for drug development, are characterized by broad activities and are individually gaining traction as alternatives to mono-target drug therapies. In particular, NO2-FA share key characteristics with currently approved pharmacological agents regarding reactivity, distribution, and mechanism of action. This review first presents the characteristics, liabilities, and opportunities that these different drug candidate classes display, and then discusses these issues in the context of current progress in the preclinical and clinical development of NO2-FA as drugs. Lessons learned from the novel approaches presented herein were considered early on during development to structurally define and improve NO2-FA and their disease targets." @default.
- W2811163292 created "2018-07-10" @default.
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- W2811163292 creator A5052711997 @default.
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- W2811163292 date "2018-09-01" @default.
- W2811163292 modified "2023-10-15" @default.
- W2811163292 title "Nitro-fatty acids: New drug candidates for chronic inflammatory and fibrotic diseases" @default.
- W2811163292 cites W1560062315 @default.
- W2811163292 cites W1966060541 @default.
- W2811163292 cites W1967838438 @default.
- W2811163292 cites W1972403093 @default.
- W2811163292 cites W1978094617 @default.
- W2811163292 cites W1980704359 @default.
- W2811163292 cites W1985920370 @default.
- W2811163292 cites W1990185204 @default.
- W2811163292 cites W1995182810 @default.
- W2811163292 cites W2000341835 @default.
- W2811163292 cites W2004322550 @default.
- W2811163292 cites W2004519217 @default.
- W2811163292 cites W2009702867 @default.
- W2811163292 cites W2010993054 @default.
- W2811163292 cites W2019067987 @default.
- W2811163292 cites W2022905263 @default.
- W2811163292 cites W2026310866 @default.
- W2811163292 cites W2031756172 @default.
- W2811163292 cites W2031801552 @default.
- W2811163292 cites W2036630204 @default.
- W2811163292 cites W2039550404 @default.
- W2811163292 cites W2042149164 @default.
- W2811163292 cites W2047470454 @default.
- W2811163292 cites W2058355050 @default.
- W2811163292 cites W2065880243 @default.
- W2811163292 cites W2071755201 @default.
- W2811163292 cites W2085543892 @default.
- W2811163292 cites W2094977942 @default.
- W2811163292 cites W2095768296 @default.
- W2811163292 cites W2096330355 @default.
- W2811163292 cites W2097439300 @default.
- W2811163292 cites W2099852670 @default.
- W2811163292 cites W2100123437 @default.
- W2811163292 cites W2112279385 @default.
- W2811163292 cites W2112948259 @default.
- W2811163292 cites W2114426273 @default.
- W2811163292 cites W2128123270 @default.
- W2811163292 cites W2128788220 @default.
- W2811163292 cites W2129159539 @default.
- W2811163292 cites W2129282733 @default.
- W2811163292 cites W2131133480 @default.
- W2811163292 cites W2132010550 @default.
- W2811163292 cites W2142347023 @default.
- W2811163292 cites W2143310289 @default.
- W2811163292 cites W2145009492 @default.
- W2811163292 cites W2149688550 @default.
- W2811163292 cites W2151651725 @default.
- W2811163292 cites W2156798681 @default.
- W2811163292 cites W2157947374 @default.
- W2811163292 cites W2160505738 @default.
- W2811163292 cites W2165080088 @default.
- W2811163292 cites W2167075471 @default.
- W2811163292 cites W2168919398 @default.
- W2811163292 cites W2180045916 @default.
- W2811163292 cites W2192223169 @default.
- W2811163292 cites W2220418356 @default.
- W2811163292 cites W2231490797 @default.
- W2811163292 cites W2317224349 @default.
- W2811163292 cites W2336862132 @default.
- W2811163292 cites W2346560662 @default.
- W2811163292 cites W2347160677 @default.
- W2811163292 cites W2400748902 @default.
- W2811163292 cites W2412507581 @default.
- W2811163292 cites W248383993 @default.
- W2811163292 cites W2525540730 @default.
- W2811163292 cites W2537898560 @default.
- W2811163292 cites W2557798862 @default.
- W2811163292 cites W2560836594 @default.
- W2811163292 cites W2569445223 @default.
- W2811163292 cites W2580464342 @default.
- W2811163292 cites W2589064393 @default.
- W2811163292 cites W2598819486 @default.
- W2811163292 cites W2622009965 @default.
- W2811163292 cites W2752260686 @default.
- W2811163292 cites W2775505129 @default.
- W2811163292 cites W2791312568 @default.
- W2811163292 cites W2793589433 @default.
- W2811163292 cites W2794709532 @default.
- W2811163292 cites W2799627453 @default.
- W2811163292 cites W2804638973 @default.
- W2811163292 cites W53126872 @default.
- W2811163292 cites W649026429 @default.
- W2811163292 doi "https://doi.org/10.1016/j.niox.2018.06.006" @default.
- W2811163292 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6280193" @default.
- W2811163292 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29944935" @default.
- W2811163292 hasPublicationYear "2018" @default.
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