Matches in SemOpenAlex for { <https://semopenalex.org/work/W2811172649> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2811172649 abstract "Abstract A chromatographic method has been developed and validated for the first time for analysis of terizidone in plasma. Terizidone was extracted from plasma by protein precipitation using a mixture of acetonitrile and methanol (1:1, v/v). The chromatographic separation was achieved with a gradient of acetonitrile and water both containing 0.1% formic acid on a Supelco Discovery ® HS C 18 (150 × 4.6 mm, 5 μm) reversed‐phase column. Propranolol was used as the internal standard. The total run‐time was 18 min. The calibration standard concentrations ranged between 3.125 and 200 μg/mL and calibration curves were linear with coefficient of determination values in the range of 0.9988–0.9999. The inter‐ and intra‐day assay precision (percentage relative standard error) was <15% while mean accuracy was 107%. The mean extraction efficiencies of terizidone and IS were 76 and 89%, respectively. The validation results demonstrated that the method was selective and sensitive, and that terizidone was stable under the studied conditions. The method was successfully applied in a population pharmacokinetic study. The mean plasma concentration of terizidone in patients at all sampling time points was 51.8 ± 28 μg/mL. The method was simple, cheap and hence suitable for therapeutic drug monitoring of terizidone." @default.
- W2811172649 created "2018-07-10" @default.
- W2811172649 creator A5045843488 @default.
- W2811172649 creator A5076614105 @default.
- W2811172649 date "2018-07-12" @default.
- W2811172649 modified "2023-10-14" @default.
- W2811172649 title "Analysis of terizidone in plasma using HPLC-UV method and its application in a pharmacokinetic study of patients with drug-resistant tuberculosis" @default.
- W2811172649 cites W1963779354 @default.
- W2811172649 cites W2025330324 @default.
- W2811172649 cites W2027951201 @default.
- W2811172649 cites W2090175734 @default.
- W2811172649 cites W2093002687 @default.
- W2811172649 cites W2097133372 @default.
- W2811172649 cites W2098248535 @default.
- W2811172649 cites W2107834145 @default.
- W2811172649 cites W2147213334 @default.
- W2811172649 cites W2165898417 @default.
- W2811172649 cites W2199941204 @default.
- W2811172649 doi "https://doi.org/10.1002/bmc.4325" @default.
- W2811172649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29947117" @default.
- W2811172649 hasPublicationYear "2018" @default.
- W2811172649 type Work @default.
- W2811172649 sameAs 2811172649 @default.
- W2811172649 citedByCount "5" @default.
- W2811172649 countsByYear W28111726492019 @default.
- W2811172649 countsByYear W28111726492020 @default.
- W2811172649 countsByYear W28111726492021 @default.
- W2811172649 crossrefType "journal-article" @default.
- W2811172649 hasAuthorship W2811172649A5045843488 @default.
- W2811172649 hasAuthorship W2811172649A5076614105 @default.
- W2811172649 hasConcept C105795698 @default.
- W2811172649 hasConcept C112705442 @default.
- W2811172649 hasConcept C113196181 @default.
- W2811172649 hasConcept C119128265 @default.
- W2811172649 hasConcept C179998833 @default.
- W2811172649 hasConcept C185592680 @default.
- W2811172649 hasConcept C202799725 @default.
- W2811172649 hasConcept C23531484 @default.
- W2811172649 hasConcept C2777379063 @default.
- W2811172649 hasConcept C2777463227 @default.
- W2811172649 hasConcept C33923547 @default.
- W2811172649 hasConcept C43617362 @default.
- W2811172649 hasConcept C4725764 @default.
- W2811172649 hasConcept C71924100 @default.
- W2811172649 hasConcept C74774607 @default.
- W2811172649 hasConcept C98274493 @default.
- W2811172649 hasConceptScore W2811172649C105795698 @default.
- W2811172649 hasConceptScore W2811172649C112705442 @default.
- W2811172649 hasConceptScore W2811172649C113196181 @default.
- W2811172649 hasConceptScore W2811172649C119128265 @default.
- W2811172649 hasConceptScore W2811172649C179998833 @default.
- W2811172649 hasConceptScore W2811172649C185592680 @default.
- W2811172649 hasConceptScore W2811172649C202799725 @default.
- W2811172649 hasConceptScore W2811172649C23531484 @default.
- W2811172649 hasConceptScore W2811172649C2777379063 @default.
- W2811172649 hasConceptScore W2811172649C2777463227 @default.
- W2811172649 hasConceptScore W2811172649C33923547 @default.
- W2811172649 hasConceptScore W2811172649C43617362 @default.
- W2811172649 hasConceptScore W2811172649C4725764 @default.
- W2811172649 hasConceptScore W2811172649C71924100 @default.
- W2811172649 hasConceptScore W2811172649C74774607 @default.
- W2811172649 hasConceptScore W2811172649C98274493 @default.
- W2811172649 hasFunder F4320320671 @default.
- W2811172649 hasFunder F4320320672 @default.
- W2811172649 hasIssue "11" @default.
- W2811172649 hasLocation W28111726491 @default.
- W2811172649 hasLocation W28111726492 @default.
- W2811172649 hasOpenAccess W2811172649 @default.
- W2811172649 hasPrimaryLocation W28111726491 @default.
- W2811172649 hasRelatedWork W1519049910 @default.
- W2811172649 hasRelatedWork W1650684153 @default.
- W2811172649 hasRelatedWork W1938778011 @default.
- W2811172649 hasRelatedWork W1984245414 @default.
- W2811172649 hasRelatedWork W2005624293 @default.
- W2811172649 hasRelatedWork W2026619427 @default.
- W2811172649 hasRelatedWork W2050995508 @default.
- W2811172649 hasRelatedWork W2078718962 @default.
- W2811172649 hasRelatedWork W2513224890 @default.
- W2811172649 hasRelatedWork W4212819198 @default.
- W2811172649 hasVolume "32" @default.
- W2811172649 isParatext "false" @default.
- W2811172649 isRetracted "false" @default.
- W2811172649 magId "2811172649" @default.
- W2811172649 workType "article" @default.