Matches in SemOpenAlex for { <https://semopenalex.org/work/W2811177568> ?p ?o ?g. }
- W2811177568 endingPage "9878" @default.
- W2811177568 startingPage "9841" @default.
- W2811177568 abstract "G protein-coupled receptors (GPCRs) signal through both G-protein-dependent and G-protein-independent pathways, and β-arrestin recruitment is the most recognized one of the latter. Biased ligands selective for either pathway are expected to regulate biological functions of GPCRs in a more precise way, therefore providing new drug molecules with superior efficacy and/or reduced side effects. During the past decade, biased ligands have been discovered and developed for many GPCRs, such as the μ opioid receptor, the angiotensin II receptor type 1, the dopamine D2 receptor, and many others. In this Perspective, recent advances in this field are reviewed by discussing the structure-functional selectivity relationships (SFSRs) of GPCR biased ligands and the therapeutic potential of these molecules. Further understanding of the biological functions associated with each signaling pathway and structural basis for biased signaling will facilitate future drug design in this field." @default.
- W2811177568 created "2018-07-10" @default.
- W2811177568 creator A5038759638 @default.
- W2811177568 creator A5049197736 @default.
- W2811177568 creator A5065732542 @default.
- W2811177568 creator A5073407465 @default.
- W2811177568 date "2018-06-25" @default.
- W2811177568 modified "2023-09-24" @default.
- W2811177568 title "Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure–Functional Selectivity Relationships (SFSRs) and Therapeutic Potential" @default.
- W2811177568 cites W1481471030 @default.
- W2811177568 cites W1490490649 @default.
- W2811177568 cites W1493585689 @default.
- W2811177568 cites W1503765703 @default.
- W2811177568 cites W1534858533 @default.
- W2811177568 cites W1751621284 @default.
- W2811177568 cites W1823516397 @default.
- W2811177568 cites W1825353903 @default.
- W2811177568 cites W1851767352 @default.
- W2811177568 cites W1966742656 @default.
- W2811177568 cites W1967156087 @default.
- W2811177568 cites W1970095058 @default.
- W2811177568 cites W1970693714 @default.
- W2811177568 cites W1970793561 @default.
- W2811177568 cites W1971447101 @default.
- W2811177568 cites W1971929424 @default.
- W2811177568 cites W1972513389 @default.
- W2811177568 cites W1972870079 @default.
- W2811177568 cites W1974664670 @default.
- W2811177568 cites W1975067268 @default.
- W2811177568 cites W1976944767 @default.
- W2811177568 cites W1980661511 @default.
- W2811177568 cites W1983654099 @default.
- W2811177568 cites W1985234975 @default.
- W2811177568 cites W1985873390 @default.
- W2811177568 cites W1987893946 @default.
- W2811177568 cites W1987936533 @default.
- W2811177568 cites W1996564506 @default.
- W2811177568 cites W1999561809 @default.
- W2811177568 cites W2002430259 @default.
- W2811177568 cites W2002879327 @default.
- W2811177568 cites W2006803138 @default.
- W2811177568 cites W2007337947 @default.
- W2811177568 cites W2008728387 @default.
- W2811177568 cites W2010998976 @default.
- W2811177568 cites W2011033953 @default.
- W2811177568 cites W2011312787 @default.
- W2811177568 cites W2012628363 @default.
- W2811177568 cites W2013824152 @default.
- W2811177568 cites W2014213356 @default.
- W2811177568 cites W2015087988 @default.
- W2811177568 cites W2019933465 @default.
- W2811177568 cites W2020160421 @default.
- W2811177568 cites W2023948580 @default.
- W2811177568 cites W2026421244 @default.
- W2811177568 cites W2026850235 @default.
- W2811177568 cites W2028645925 @default.
- W2811177568 cites W2029701200 @default.
- W2811177568 cites W2031155993 @default.
- W2811177568 cites W2032787297 @default.
- W2811177568 cites W2036268648 @default.
- W2811177568 cites W2037276555 @default.
- W2811177568 cites W2038538575 @default.
- W2811177568 cites W2039482493 @default.
- W2811177568 cites W2040565189 @default.
- W2811177568 cites W2046530404 @default.
- W2811177568 cites W2047567287 @default.
- W2811177568 cites W2053549636 @default.
- W2811177568 cites W2056188558 @default.
- W2811177568 cites W2059628641 @default.
- W2811177568 cites W2060165446 @default.
- W2811177568 cites W2060177143 @default.
- W2811177568 cites W2062106032 @default.
- W2811177568 cites W2064634578 @default.
- W2811177568 cites W2067724628 @default.
- W2811177568 cites W2068986257 @default.
- W2811177568 cites W2070357412 @default.
- W2811177568 cites W2071741407 @default.
- W2811177568 cites W2076323933 @default.
- W2811177568 cites W2077028400 @default.
- W2811177568 cites W2078748771 @default.
- W2811177568 cites W2081128554 @default.
- W2811177568 cites W2082956345 @default.
- W2811177568 cites W2082994579 @default.
- W2811177568 cites W2083725367 @default.
- W2811177568 cites W2091939203 @default.
- W2811177568 cites W2092716816 @default.
- W2811177568 cites W2097298436 @default.
- W2811177568 cites W2097744565 @default.
- W2811177568 cites W2097747770 @default.
- W2811177568 cites W2098688157 @default.
- W2811177568 cites W2099817260 @default.
- W2811177568 cites W2104477830 @default.
- W2811177568 cites W2105006312 @default.
- W2811177568 cites W2108361656 @default.
- W2811177568 cites W2109014958 @default.
- W2811177568 cites W2109058223 @default.
- W2811177568 cites W2109083102 @default.
- W2811177568 cites W2111373319 @default.