Matches in SemOpenAlex for { <https://semopenalex.org/work/W2811189912> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2811189912 endingPage "e446" @default.
- W2811189912 startingPage "e439" @default.
- W2811189912 abstract "Background The aim of this study was to compare the pharmacokinetic profile, tolerability, and safety of a novel once-daily extended-release formulation of tacrolimus (LCPT) with that of once-daily prolonged-release tacrolimus (ODT) in stable adult lung transplant (LT) recipients. Methods Phase II, open-label, single-arm, single-center, prospective pilot pharmacokinetic study. Study population comprised 20 stable LT recipients receiving ODT, mean age 55.9 years (range, 38-67 years), 13 (65%) men. Patients were switched to LCPT in a 1:0.7 (mg/mg) conversion dose. Follow-up was 6 months, and cystic fibrosis patients were excluded. Two 24-hour pharmacokinetic profiles were obtained for each patient, the first on day −14 and the second on day +14 after switching to LCPT. Pharmacokinetic parameters and safety were compared. Results Mean (SD) area under the concentration-time curve from 0 to 24 hours was 253.97 (61.90) ng/mL per hour for ODT and 282.44 (68.2) ng/mL per hour for LCPT. Systemic exposure was similar in both (Schuirmann two 1-sided test). Mean (SD) dose was 5.05 (1.67) mg in ODT and 3.36 (1.03) mg in LCPT ( P = 0.0002). Time to maximum concentration was 125 minutes for ODT and 325 minutes for LCPT ( P < 0.001). Correlation between area under the concentration-time curve from 0 to 24 hours and C24 was 0.896 ( r 2 ) for ODT and 0.893 ( r 2 ) for LCPT. There were no differences in adverse effects. At 6 months, conversion dose was 1:0.59 (mg/mg) in patients with unchanged minimum plasma concentration target levels. Conclusions Switching from ODT to LCPT was safe and well tolerated in stable LT recipients without cystic fibrosis. A significantly lower dose of LCPT allows similar bioavailability. A conversion ratio 1:0.6 could be enough to maintain similar target levels." @default.
- W2811189912 created "2018-07-10" @default.
- W2811189912 creator A5006106557 @default.
- W2811189912 creator A5013770911 @default.
- W2811189912 creator A5021055795 @default.
- W2811189912 creator A5024095222 @default.
- W2811189912 creator A5033452620 @default.
- W2811189912 creator A5040375770 @default.
- W2811189912 creator A5051009231 @default.
- W2811189912 creator A5087424904 @default.
- W2811189912 creator A5091490869 @default.
- W2811189912 date "2018-10-01" @default.
- W2811189912 modified "2023-10-07" @default.
- W2811189912 title "Pharmacokinetic Study of Conversion Between 2 Formulations of Once-daily Extended-release Tacrolimus in Stable Lung Transplant Patients" @default.
- W2811189912 cites W1480151031 @default.
- W2811189912 cites W1599829994 @default.
- W2811189912 cites W1929309318 @default.
- W2811189912 cites W1999400963 @default.
- W2811189912 cites W2037698344 @default.
- W2811189912 cites W2045505368 @default.
- W2811189912 cites W2089557861 @default.
- W2811189912 cites W2204234552 @default.
- W2811189912 cites W2463371736 @default.
- W2811189912 doi "https://doi.org/10.1097/tp.0000000000002348" @default.
- W2811189912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29965950" @default.
- W2811189912 hasPublicationYear "2018" @default.
- W2811189912 type Work @default.
- W2811189912 sameAs 2811189912 @default.
- W2811189912 citedByCount "5" @default.
- W2811189912 countsByYear W28111899122020 @default.
- W2811189912 countsByYear W28111899122022 @default.
- W2811189912 countsByYear W28111899122023 @default.
- W2811189912 crossrefType "journal-article" @default.
- W2811189912 hasAuthorship W2811189912A5006106557 @default.
- W2811189912 hasAuthorship W2811189912A5013770911 @default.
- W2811189912 hasAuthorship W2811189912A5021055795 @default.
- W2811189912 hasAuthorship W2811189912A5024095222 @default.
- W2811189912 hasAuthorship W2811189912A5033452620 @default.
- W2811189912 hasAuthorship W2811189912A5040375770 @default.
- W2811189912 hasAuthorship W2811189912A5051009231 @default.
- W2811189912 hasAuthorship W2811189912A5087424904 @default.
- W2811189912 hasAuthorship W2811189912A5091490869 @default.
- W2811189912 hasBestOaLocation W28111899121 @default.
- W2811189912 hasConcept C112705442 @default.
- W2811189912 hasConcept C126894567 @default.
- W2811189912 hasConcept C141071460 @default.
- W2811189912 hasConcept C197934379 @default.
- W2811189912 hasConcept C2778375690 @default.
- W2811189912 hasConcept C2780073493 @default.
- W2811189912 hasConcept C2781448352 @default.
- W2811189912 hasConcept C2908647359 @default.
- W2811189912 hasConcept C2909675724 @default.
- W2811189912 hasConcept C2911091166 @default.
- W2811189912 hasConcept C42219234 @default.
- W2811189912 hasConcept C71924100 @default.
- W2811189912 hasConcept C76318530 @default.
- W2811189912 hasConcept C98274493 @default.
- W2811189912 hasConcept C99454951 @default.
- W2811189912 hasConceptScore W2811189912C112705442 @default.
- W2811189912 hasConceptScore W2811189912C126894567 @default.
- W2811189912 hasConceptScore W2811189912C141071460 @default.
- W2811189912 hasConceptScore W2811189912C197934379 @default.
- W2811189912 hasConceptScore W2811189912C2778375690 @default.
- W2811189912 hasConceptScore W2811189912C2780073493 @default.
- W2811189912 hasConceptScore W2811189912C2781448352 @default.
- W2811189912 hasConceptScore W2811189912C2908647359 @default.
- W2811189912 hasConceptScore W2811189912C2909675724 @default.
- W2811189912 hasConceptScore W2811189912C2911091166 @default.
- W2811189912 hasConceptScore W2811189912C42219234 @default.
- W2811189912 hasConceptScore W2811189912C71924100 @default.
- W2811189912 hasConceptScore W2811189912C76318530 @default.
- W2811189912 hasConceptScore W2811189912C98274493 @default.
- W2811189912 hasConceptScore W2811189912C99454951 @default.
- W2811189912 hasIssue "10" @default.
- W2811189912 hasLocation W28111899121 @default.
- W2811189912 hasLocation W28111899122 @default.
- W2811189912 hasLocation W28111899123 @default.
- W2811189912 hasOpenAccess W2811189912 @default.
- W2811189912 hasPrimaryLocation W28111899121 @default.
- W2811189912 hasRelatedWork W2087016115 @default.
- W2811189912 hasRelatedWork W2155927082 @default.
- W2811189912 hasRelatedWork W2794766773 @default.
- W2811189912 hasRelatedWork W2794773248 @default.
- W2811189912 hasRelatedWork W3032718254 @default.
- W2811189912 hasRelatedWork W3150855330 @default.
- W2811189912 hasRelatedWork W3191427281 @default.
- W2811189912 hasRelatedWork W3207196874 @default.
- W2811189912 hasRelatedWork W4200557508 @default.
- W2811189912 hasRelatedWork W4311628015 @default.
- W2811189912 hasVolume "102" @default.
- W2811189912 isParatext "false" @default.
- W2811189912 isRetracted "false" @default.
- W2811189912 magId "2811189912" @default.
- W2811189912 workType "article" @default.