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- W2811244848 endingPage "17404" @default.
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- W2811244848 abstract "Abstract Cysteine‐based native chemical ligation (NCL) has been a very powerful approach for convergent synthesis of peptides and proteins. However, owing to the low abundance of cysteine (Cys) in proteins, applications of NCL in protein chemical synthesis are limited. To expand the peptide ligation toolbox, NCL followed by desulfurization has been developed to enable peptide ligation at Xaa‐Ala conjunctions, that is, formal “alanine ligation”. In this regard, effective peptide desulfurization methods are critical. This Concept article summarizes the development of different desulfurization strategies for peptide and protein chemical synthesis." @default.
- W2811244848 created "2018-07-10" @default.
- W2811244848 creator A5031950204 @default.
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- W2811244848 date "2018-10-08" @default.
- W2811244848 modified "2023-10-17" @default.
- W2811244848 title "Advances in Native Chemical Ligation–Desulfurization: A Powerful Strategy for Peptide and Protein Synthesis" @default.
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- W2811244848 doi "https://doi.org/10.1002/chem.201802067" @default.
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