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• W2811297181 abstract "Drosophila imaginal discs often change their cell fate under stress conditions, and this phenomenon, called transdetermination (TD), has long been a useful model for studying cell fate plasticity during regeneration. We previously identified a chromatin-associated protein, Winged Eye (Wge), which induces eye-to-wing TD upon its over-expression in eye imaginal discs. However, the molecular mechanism of Wge-mediated TD remains obscure. Here, we analyzed Wge-interacting proteins and found that several heterochromatin-related proteins, including a nuclear lamina protein, Lamin (Lam), were associated with Wge protein in cultured cells. Knockdown experiments revealed that Lam is indeed required for Wge-mediated eye-to-wing TD. Moreover, Wge over-expression altered the spatial organization of genomic DNA inside the cell nuclei. Accordingly, we suggest that Wge interacts with Lam to link some genomic regions with the nuclear periphery and regulates chromatin dynamics in imaginal disc TD." @default.
• W2811297181 created "2018-07-10" @default.
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• W2811297181 date "2018-07-02" @default.
• W2811297181 modified "2023-10-12" @default.
• W2811297181 title "Nuclear Lamin is required for Winged Eye‐mediated transdetermination of Drosophila imaginal disc" @default.
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• W2811297181 doi "https://doi.org/10.1111/gtc.12608" @default.
• W2811297181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29968323" @default.
• W2811297181 hasPublicationYear "2018" @default.
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