Matches in SemOpenAlex for { <https://semopenalex.org/work/W2811313602> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2811313602 endingPage "1408" @default.
- W2811313602 startingPage "1402" @default.
- W2811313602 abstract "Human herpes virus 6 (HHV-6) is a member of the β-herpesvirinae subfamily. Most people acquire HHV-6 primary infection early in life and reactivation may occur, most often in immunocompromised individuals, leading to various clinical manifestations. HHV-6 infected cells may be identified in lymph nodes in both reactive and neoplastic conditions. Cases were retrieved from the hematopathology consultation service archives at National Institutes of Health from 2003 to 2017 in which infection by HHV-6 had been documented by immunohistochemical stains to HHV-6 gp60/110 envelope glycoprotein. Five cases of reactive lymphadenitis and 3 cases of lymphoma; 2 angioimmunoblastic T-cell lymphoma and 1 classic Hodgkin lymphoma, positive for HHV-6 were identified. The reactive lymph nodes showed marked paracortical hyperplasia and admixed large atypical lymphoid cells exhibiting pleomorphic nuclei, vesicular chromatin, and prominent eosinophilic intranuclear inclusions. Vascular proliferation and necrosis were also present, raising suspicion of peripheral T-cell lymphoma. The 3 cases of lymphoma showed similar viral inclusions, in addition to the characteristic features diagnostic of the lymphoma. Staining for HHV-6 was positive with a membranous and Golgi pattern and was restricted to cells with evident inclusions on hematoxylin and eosin. HHV-6 infected cells were positive for CD3 and CD4. HHV-6 lymphadenitis can present with morphologic atypia creating a diagnostic pitfall for lymphoma. In such cases, careful attention to the characteristic viral inclusions can lead to immunohistochemical analysis highlighting the replicating virus. In cases of lymphoma, identification of the inclusions is key in detecting the associated infection as well as in avoiding misinterpretation of the lymphoma subtype." @default.
- W2811313602 created "2018-07-10" @default.
- W2811313602 creator A5002368482 @default.
- W2811313602 creator A5004302536 @default.
- W2811313602 creator A5005427809 @default.
- W2811313602 creator A5024701461 @default.
- W2811313602 creator A5040855823 @default.
- W2811313602 creator A5089779163 @default.
- W2811313602 date "2018-10-01" @default.
- W2811313602 modified "2023-09-29" @default.
- W2811313602 title "Human Herpes Virus 6 (HHV-6)–associated Lymphadenitis" @default.
- W2811313602 cites W1213705266 @default.
- W2811313602 cites W1568829012 @default.
- W2811313602 cites W1723150221 @default.
- W2811313602 cites W1824833029 @default.
- W2811313602 cites W1963829537 @default.
- W2811313602 cites W1999091319 @default.
- W2811313602 cites W2017910380 @default.
- W2811313602 cites W2020094108 @default.
- W2811313602 cites W2032583606 @default.
- W2811313602 cites W2034806350 @default.
- W2811313602 cites W2038530422 @default.
- W2811313602 cites W2042451168 @default.
- W2811313602 cites W2044979275 @default.
- W2811313602 cites W2049198408 @default.
- W2811313602 cites W2050089095 @default.
- W2811313602 cites W2080186683 @default.
- W2811313602 cites W2092528272 @default.
- W2811313602 cites W2097166141 @default.
- W2811313602 cites W2107373453 @default.
- W2811313602 cites W2111044841 @default.
- W2811313602 cites W2117045214 @default.
- W2811313602 cites W2126193184 @default.
- W2811313602 cites W2127986618 @default.
- W2811313602 cites W2155272224 @default.
- W2811313602 cites W2156936353 @default.
- W2811313602 cites W2220111011 @default.
- W2811313602 doi "https://doi.org/10.1097/pas.0000000000001121" @default.
- W2811313602 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6133726" @default.
- W2811313602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29975251" @default.
- W2811313602 hasPublicationYear "2018" @default.
- W2811313602 type Work @default.
- W2811313602 sameAs 2811313602 @default.
- W2811313602 citedByCount "6" @default.
- W2811313602 countsByYear W28113136022020 @default.
- W2811313602 countsByYear W28113136022021 @default.
- W2811313602 countsByYear W28113136022022 @default.
- W2811313602 countsByYear W28113136022023 @default.
- W2811313602 crossrefType "journal-article" @default.
- W2811313602 hasAuthorship W2811313602A5002368482 @default.
- W2811313602 hasAuthorship W2811313602A5004302536 @default.
- W2811313602 hasAuthorship W2811313602A5005427809 @default.
- W2811313602 hasAuthorship W2811313602A5024701461 @default.
- W2811313602 hasAuthorship W2811313602A5040855823 @default.
- W2811313602 hasAuthorship W2811313602A5089779163 @default.
- W2811313602 hasBestOaLocation W28113136022 @default.
- W2811313602 hasConcept C104317684 @default.
- W2811313602 hasConcept C142724271 @default.
- W2811313602 hasConcept C174475383 @default.
- W2811313602 hasConcept C2779060813 @default.
- W2811313602 hasConcept C2779338263 @default.
- W2811313602 hasConcept C2780117679 @default.
- W2811313602 hasConcept C30481170 @default.
- W2811313602 hasConcept C55493867 @default.
- W2811313602 hasConcept C71924100 @default.
- W2811313602 hasConcept C86803240 @default.
- W2811313602 hasConceptScore W2811313602C104317684 @default.
- W2811313602 hasConceptScore W2811313602C142724271 @default.
- W2811313602 hasConceptScore W2811313602C174475383 @default.
- W2811313602 hasConceptScore W2811313602C2779060813 @default.
- W2811313602 hasConceptScore W2811313602C2779338263 @default.
- W2811313602 hasConceptScore W2811313602C2780117679 @default.
- W2811313602 hasConceptScore W2811313602C30481170 @default.
- W2811313602 hasConceptScore W2811313602C55493867 @default.
- W2811313602 hasConceptScore W2811313602C71924100 @default.
- W2811313602 hasConceptScore W2811313602C86803240 @default.
- W2811313602 hasIssue "10" @default.
- W2811313602 hasLocation W28113136021 @default.
- W2811313602 hasLocation W28113136022 @default.
- W2811313602 hasLocation W28113136023 @default.
- W2811313602 hasLocation W28113136024 @default.
- W2811313602 hasOpenAccess W2811313602 @default.
- W2811313602 hasPrimaryLocation W28113136021 @default.
- W2811313602 hasRelatedWork W18636256 @default.
- W2811313602 hasRelatedWork W2045348280 @default.
- W2811313602 hasRelatedWork W2131886022 @default.
- W2811313602 hasRelatedWork W2314451028 @default.
- W2811313602 hasRelatedWork W2335847372 @default.
- W2811313602 hasRelatedWork W2336814365 @default.
- W2811313602 hasRelatedWork W2398593007 @default.
- W2811313602 hasRelatedWork W2424246054 @default.
- W2811313602 hasRelatedWork W2887031259 @default.
- W2811313602 hasRelatedWork W2977162189 @default.
- W2811313602 hasVolume "42" @default.
- W2811313602 isParatext "false" @default.
- W2811313602 isRetracted "false" @default.
- W2811313602 magId "2811313602" @default.
- W2811313602 workType "article" @default.