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• W2811316771 abstract "From 1987 and during the following 20 years, a few research teams exploring bacteria and archea genome sequences uncover the prokaryotic adaptative immune system made of the CRISPR sequence and associated cas genes. First believed to be similar to the eukaryote RNA interference system, CRISPR-Cas turned out to be unique and of an amazing genetic complexity. The comparative studies of CRISPR arrays and of cas, and later of microbiotes metagenomes allowed to propose an evolution scenario for these systems. The results demonstrate the importance of a naturalistic approach, without a priori, for the understanding of living organisms." @default.
• W2811316771 created "2018-07-10" @default.
• W2811316771 creator A5020235101 @default.
• W2811316771 date "2017-01-01" @default.
• W2811316771 modified "2023-09-25" @default.
• W2811316771 title "Historique de la découverte des systèmes CRISPR-Cas" @default.
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• W2811316771 doi "https://doi.org/10.1051/jbio/2018001" @default.
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