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- W2811321492 abstract "Purpose: To investigate whether irradiated volume of pelvic active bone marrow (ACTBM) may predict decreased blood cells nadirs in anal cancer patients undergoing concurrent chemo-radiation.Methods: Forty-four patients were analyzed and pelvic active bone marrow (ACTBM) was characterized employing 18FDG-PET. Dosimetric parameters on dose–volume histograms were correlated to nadirs with generalized linear modeling.Results: ACTBM mean dose was significantly correlated to white blood cell (β = −1.338; 95%CI: −2.455/−0.221; p = 0.020), absolute neutrophil count (β = −1.651; 95%CI: −3.284/−0.183; p = 0.048), and platelets (β = −0.031; 95%CI: −0.057/−0.004; p = 0.024) nadirs. Other dosimetric parameters were found to be correlated (ACTBM-V10,-V20,-V30and-V40).Conclusions: 18FDG-PET is able to define active bone marrow and may predict for decreased blood cells count nadirs." @default.
- W2811321492 created "2018-07-10" @default.
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- W2811321492 date "2018-05-28" @default.
- W2811321492 modified "2023-09-25" @default.
- W2811321492 title "Dose to Pelvic Bone Marrow Defined with FDG-PET Predicts for Hematologic Nadirs in Anal Cancer Patients Treated with Concurrent Chemo-radiation" @default.
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- W2811321492 doi "https://doi.org/10.1080/07357907.2018.1479413" @default.
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